Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuropath > Opioids > Flashcards

Opioids Flashcards

1
Q

Fentanyl

A

full mu agonist

no active metabolite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Morphine

A 
full mu agonist
hydromorphone
oxymorphone
contraindicated in brain injury and emphysema 
Met by CYP3A4 to inactive metabolite
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Buprenorphine

A

partial mu agonist
delta agonist
kappa antagonist
office based detox/withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Codeine

A 
Full agonist
moderate analgesic 
hydrocodone
oxycodone
met to morphine by CYP2D6
weak mu agonist  
less potential for drug dependence and respiratory depression
antitussive
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Levorphanol

A

full mu agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

meperidine

A

Demerol
full mu agonist
moderate analgesic
causes mydriasis rather than miosis (avoid detection of abuse)
toxic metabolite, normeperidine can cause seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

tramadol

A

full mu agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

methadone

A

full mu agonist
longer half life and bioavailability compared to morphine
used for withdrawal and detox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Butorphanol

A

Kappa agonist

partial mu agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Nalbuphine

A

partial mu agonist

kappa agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Naltrexone

A

oral full antagonist
antidote for OD
long duration of action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

eluxadoline

A

mixed agonist/antagonist

GI specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Naloxegol

A

GI specific full antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mu Receptor Effects

A 
analgesia (supra-spinal)
euphoria 
CNS and respiratory depression
Dependence
Miosis 
Constipation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Kappa receptor effects

A

analgesia (spinal)
CNS and respiratory depression
Miosis
Dysphoria/disorientation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Delta receptor effects

A

Analgesia (supra spinal and spinal)

17
Q

sulfentanil

A

Kappa, delta and mu agonist
100x more potent than morphine and methadone
short acting

18
Q

remifentanil

A

VERY short acting

high potency full agonist

19
Q

CYP2D6

A

met codeine to morphine

alleles affect pts response

20
Q

dextromethorphan

A

antitussive independent of opioid receptors

not addictive or analgesic

21
Q

tramadol

A

moderate mu agonist
inhibits catecholamine reuptake
- caution in pts on tricyclics or SSRI’s
associated with seizures

22
Q

Naloxone

A

IV mu antagonist
used for OD
short duration of action

23
Q

hydromorphone

A

active metabolite of morphine

Neuropath (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions