Opioids

Question 1

Which opioids are serotonergic

Answer 1

Methadone, Meperidine, Tramadol

Question 2

Which opioid agents are absolutely contraindicated with alcohol use?

Answer 2

Avenza, Nucynta ER, Opana ER

Question 3

Which opioid agents are substrates of 2D6

Answer 3

Codeine, hydrocodone, oxycodone, Meperidine, Methadone(lesser degree), Tramadol

Question 4

Which opioids are prodrugs

Answer 4

Codeine, Hydrocodone, oxycodone, Tramadol

Question 5

If a patient is identified as a 2D6 ultra rapid or poor metabolizer, what does that mean for opioid use?

Answer 5

If codeine is chosen as the opioid of use, caution must be taken, as ultra rapid metabolizers will convert codeine to morphine more rapidly = possible toxicity in children & breast fed infants. Poor metabolizers will be in pain as the active morphine is not being created

Question 6

Which opioid has the highest GI toxicity

Answer 6

codeine

Question 7

If a pt is already experiencing constipation or N/V, which opioid

Answer 7

A