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Prueba General > Opioides > Flashcards

Opioides Flashcards

1
Q

como funciona opioide endogeno

A

inhie adenilato ciclasa
: dism AMPc
activacion canales de Ca+ y K+
activacion PKC

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2
Q

como funciona opioide exogeno

A

aumenta AMPc

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3
Q

de mayor a menor potencia

A 
sufentanilo
fentanilo
alfentanilo
remifentanilo
metadona
morfina
meperidina
codeina
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4
Q

de mayor a menor latencia

A 
alfentanilo
remifentanil
morfina
sufentanilo
fentanilo
meperidina
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5
Q

receptores prutio

A

u

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6
Q

receptores antiprurito

A

k

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7
Q

efecto genitourinario

A

u, delta

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8
Q

opioides naturales

A

morfina
papaverina
tebaina

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9
Q

opioides semisinteticos

A 
heroina
dehidromorfina
bupremorfina
codeina
oxicodona
oximorfona
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10
Q

opioides sinteticos

A

metadona
levorfanol
pentazocina
fenilpiperidinas: fentanil, remifentanil, alfentanil, sufentanil, meperidina

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11
Q

definicion opiaceo

A

farmaco que contiene opio (naturales)

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12
Q

definicion opioide

A

agente exogeno o endogeno que tiene afinidad por receptor opioide

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13
Q

opoide potencia debil

A

codeina
tramadol
hidrocodona
dextropropoxifeno

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14
Q

opioide potencia intermedia

A 
morfina
metadona
oxicodona
hidromorfona
buprenorfina
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15
Q

opioides potencia potente

A 
fentanilo
alfentanilo
sufentanilo
remifentanilo
etorfina
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16
Q

buprenorfina (agonista/antagonista receptores )

A

full agonista detla
agonista parcial mu
antagonista kappa

17
Q

opioide agonista parcial

A

butorfanol

buprenorfina

18
Q

antagonista competitivo

A

naloxona

naltrexona

19
Q

opide inicio accion rapida

A

remifentanilo

alfentanilo

20
Q

opioide inicio de accion lenta

A

morfina

buprenorfina

21
Q

receptores no analgesicos

A

mu3 kappa 2

22
Q

capacidad opioide de atravesar BHE

A

menor peso molecular
forma no ionizada
mayor liposolubilidad
menor union a proteinas

23
Q

manejo prurito

A

naloxona propofol, anti H1

24
Q

receptores efecto GI

A

mu, delta, kappa

25
Q

receptores efecto genitourinario

A

mu, delta

26
Q

caracteristicas morfina

A 
bradipnea
vasodilatacion
dism RVS
bradicardia
hipotension
lib histamina
act simpaticolitiva
lib histamina dosis dependiente, dism RVS, no efecto mu
27
Q

|caracteristicas meperidina

A

convulsiones
aumenta FC
disminute escalofriios, metabolismo neuro toxico SNC, disminuye prurito

28
Q

fentanilo

A

induce actividad epileptiforme en epilepticos
depresion resp con dosis analgesica
CV: estable HD

29
Q

caracteristicas sufentanilo

A

mayor depresion respiratoria
CV: mayor estabilidad que todos
mas potente que todos

30
Q

alfentanilo

A

epileptirfome

depresion resp con mayor dosis

Prueba General (6 decks)

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