Opioid Kinetics (selected) Flashcards
1
Q
Morphine
A
Lipid insoluble (sm bbb) Nl doses dont accumulate in tissue Metab: glucuronidation in 1st pass - 50% to morphine-3-glucoronide, 15% to morphine-6-glucuronide "M6G" (pharm effects)
Morphine
Lipid insoluble (sm bbb) Nl doses dont accumulate in tissue Metab: glucuronidation in 1st pass - 50% to morphine-3-glucoronide, 15% to morphine-6-glucuronide "M6G" (pharm effects)