Opioid Analgesics And Antagonists

Question 1

Codeine

Answer 1

Full agonist

Metabolites: hydrocodone and oxycodone

Question 2

Fentanyl

Answer 2

Full agonist

Metabolites: alfentanil, remifentanil, sufentanil

Question 3

Levorphanol

Answer 3

Full agonist

Question 4

Meperidine

Answer 4

Full agonist

Question 5

Morphine

Answer 5

Full agonist

Metabolites: hydromorphone* and oxymorphone

Question 6

Tramadol

Answer 6

Full agonist

Question 7

Methadone

Answer 7

Full agonist

Question 8

Buprenorphine

Answer 8

Partial agonist

Question 9

Butorphanol (k)

Answer 9

Partial agonist

Question 10

Nalbuphine

Answer 10

Partial agonist

Question 11

Naloxone (narcan ; IV)

Answer 11

Full antagonists

Question 12

Naltrexone (oral)

Answer 12

Full antagonists

Question 13

Tramadol##

Answer 13

Inhibits catecholamine reuptake

Can cause seizures if you take a lot

Question 14

Meperidine###

Answer 14

Full agonist, eyes: pupil dilation (unique)

Normeperdine (a metabolite) is toxic and can cause seizures if it accumulates

Rarely given to pts now

Question 15

Methadone##

Answer 15

Longer half life and better bioavailability than morphine

Pts addicted to opioids- give and it helps decrease peaks/troughs that drive them to seeking/abusing

Question 16

Antidote for opioid OD

Answer 16

Naloxone (aka Narcan)- typical one given

Naktrexone- long duration of action (48 hrs)- given orally