Opiods

Question 1

Name the 1 partial agonist opioid

Answer 1

BUPRENORPHINE

Question 2

Name the 2 pure opioid antagonists

Answer 2

NALOXONE

NALTREXONE

Question 3

Name the 3 mixed agonist-antagonists.

Answer 3

PENTAZOCINE
NALBUPHINE
BUTORPHANOL

Question 4

Name the 3 main types of ENDOGENOUS opioids

Answer 4

ENDORPHINS (MORPHINE)
ENKEPHALINS
DYNORPHINS

Question 5

Name the 2 actions of endogenous opioid peptides.

Answer 5

ACTION 1: Modulate pain transmission in the spinal cord

ACTION 2: Alter Ach release in the GI myenteric plexus

Question 6

What is the precursor of beta endorphins? Which hormone does this precursor also release as a result of cleavage event?

Answer 6

POMC: Cleavage results in MELATONIN + ACTH - which then releases cortisol

Question 7

Name the 2 full agonist opioids

Answer 7

FENTANYL

MORPHINE

Question 8

ANKI: Opiod Analgesics inhibit the release of which 5 substances?

Answer 8

1) Ach
2) Serotonin
3) NE
4) Glu
5) Substance P

Question 9

ANKI: Which 2 opioid toxicities do NOT develop tolerance?

Answer 9

MIOSIS

CONSTIPATION

Question 10

ANKI: What are the 2 causes of opioid-induced GI pain?

Answer 10

1. CONSTIPATION from decreased motility

2. BILIARY COLIC from smooth muscle spasm of sphincter of Odi