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Pharma PLE | Des > Ophtha / Protozoa > Flashcards

Ophtha / Protozoa Flashcards

1
Q

Causes hematotoxicity (megaloblastic anemia, thrombocyptopenia)

A

Sulfadiazine-pyrimethamine

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2
Q

This immobilizes microfilariae and alters their surface structure

A

Diethylcarbamazine

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3
Q

It inhibits trypanothione reductase

A

Nifurtimox

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4
Q

DOC: ascariasis, hookworm, pinworm, hydatid dse

A

Albendazole

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5
Q

This drug may cause Mazotti reaction when used for onchocerciasis

A

Diethylcarbamazine

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6
Q

Antiprotozoal that inhibits chon synthesis

Blocks ribosomal movement along messenger RNA

A

Emetine

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7
Q

Anti-malaria

MOA: impairs progeny of malarial apicoplast genes, resulting in abnormal cell division

A

Doxycycline

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8
Q

DOC for malaria in pregnant patients

A

Quinine

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9
Q

Antimalaria that causes methemoglobinemia

A

Primaquine

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10
Q

Uncomplicated Chloroquine-resistant P. Falciparum

A

Artemether + Lumefantrine (CoArtem)

Malarone or Mefloquine or Quinine Sulfate + Clindamycin

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11
Q

DOC: Balantidium Coli

A

Tetracycline

Metronidazole

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12
Q

Antihelminthic

MOA: selectively inhibits microtubule synthesis and glucose uptake in nematodes. Inhibits fumarate reductase

A

Thiabendazole

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13
Q

Antihelminthic

MOA: Selectively inhibits microtubule synthesis and glucose uptake in nematodes

A

Mebendazole

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14
Q

DOC for Trichinosis

A

Thiabendazole

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15
Q

Decreases secretion of aqueous humor from ciliary epithelium

A

Timolol - B blocker
Mannitol - osmotic agent
Apraclonidine - a2 agonist
Acetazolamide, Dorzolamide - carbonic anhydrase inhibitors

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16
Q

Drug of choice for cryptosporidiosis

A

Nitazoxanide

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17
Q

Avoid ethanol consumption for 48H upon drug administration

A

Niclosamide

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18
Q

Antiprotozoal causes Agranulocytosis

A

Suramin

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19
Q

Used for African sleeping sickness

A

Pentamidine

Suramin

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20
Q

DOC: Isospora belli

A

TMP-SMX

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21
Q

DOC: Microsporidia

A

Albendazole

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22
Q

Antiprotozoal

MOA: reactive reduction by ferredoxin forming free radicals that disrupt electron transport chain

A

Nitazoxanide

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23
Q

DOC for Toxoplasmosis

A

Sulfadiazine-Pyrimethamine

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24
Q

Antihelminthic

Inhibits microtubule assembly

A

Albendazole

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25
Antiprotozoal that causes cardiotoxicity (T wave changes, QT prolongation)
Na Stibogluconate
26
Drug of choice for pneumocystosis
Co-trimoxazole
27
DOC for african sleeping sickness
Melarsoprol
28
Severe or Complicated P. Falciparum
Artesunate then Doxycycline or Clindamycin or CoArtem
29
Malaria chemoprophylaxis | For multidrug-resistant areas
Doxycycline
30
Antihelmithic | That should not be given to pts with cirrhosis
Albendazole
31
Causes metallic taste, leukopenia and disulfiram reaction
Metronidazole
32
Malaria chemoprophylaxis | For chloroquine sensitive areas
Chloroquine
33
Antiprotoxal, antibiotic | MOA: reactive reduction by ferredoxin forming free radicals that disrupt electron transport chain
Metronidazole
34
DOC for Chagas disease
Nifurtimox
35
Antimalaria | MOA: sequential blockade of folic acid synthesis
Sulfadoxine-pyrimethamine
36
Antimalaria that causes cardiac conduction defects
Mefloquine
37
DOC for severe intestinal and extraintestinal amebiasis
metronidazole
38
DOC for trematodes: schistosomaa, paragonimus, clorchis, opistorchis, fasciolopsis, heterophyes Cestodes: taenia, diphyllobotrhium, hymenolepsis
Praziquantel
39
Antihelminthic MOA: stimulates nicotinic receptors at NMJ of nematodes Causes depolarization-induced paralysis
Pyrantel Pamoate
40
Antihelminthic that is contraindicated in children <5 yo and pregnant pt
Ivermectin
41
Causes pseudomembranous colitis
Clindamycin
42
DOC: Toxoplasma Gondii
Pyrimethamine + Clindamycin + Folinic acid or Spiramycin
43
Antihelminthic that is contraindicated in pts with hepatic dysfunction
Pyrantel Pamoate
44
Antimalarial that causes cardiotoxicity (prolongs PR and QT interval)
Halofantrine
45
DOC: Trypanosoma Cruzi
Nifurtimox | Benznidazole
46
Tx of Glaucoma | MOA: increased outflow via uveoscleral veins
Epinephrine - nonselective a-agonists
47
DOC for ascaris, hookworm pinworm infections
Pyrantel Pamoate
48
Antihelminthic | MOA: intensifies GABA-mediated neurotransmission in nematodes. Immobilizes parasites
Ivermectin
49
DOC for Leishmaniasis
Sodium Stibogluconate
50
DOC: Pneumocystic jivoreci
TMP-SMX
51
Drug of choice for asymptomatic cyst carrier of E. Hystolytica
Diloxanide furoate
52
DOC for Filariasis and eye worm disease
Diethylcarbamazine
53
DOC for uncomplicated falciparum malaria in PH
Artemisinin
54
Malaria chemoprophylaxis | For chloroquine resistant areas
Mefloquine Malarone
55
Anithelminthic that is contraindicated in pregnancy
Thiabendazole
56
DOC for babesia
Clindamycin | Quinine
57
Flow of Aqeuos Humor
Ciliary body - posterior chamber - anterior chamber angle - pupil - anterior chamber - trabecular meshwork - canal of Schlem - uveoscleral veins
58
MOA: | Sequential blockade of dihydropteroate synthase (sulfamethoxazole) and dihydrofolate reductase (trimethroprim)
Co-trimoxazole | Sulfadiazine-Pyrimethamine
59
This drug is an antimalira and a tetracycline antibiotic as well
Doxycycline
60
Antiprotozoal drug that causes thrombocytopenia, Leukopenia, Seizures
Eflornithine
61
Causes Mazzotti reaction
Ivermectin | DEC
62
Causes acute hemolysis in G6PD deficiency, assume cross-hypersensitivity, SJS, toxic epidermal necrolysis
Co-trimoxazole
63
Antiprotozal, aminoglycoside MOA: inhibits protein synthesis Binds to 16S ribosomal subunit Luminal amebicide
Paromomycin
64
Tx for glaucoma | MOA: ciliary muscle contraction opening of trabecular meshwork, increased outflow
Pilocarpine, Physostigmine - cholinomimetics
65
Antimalarial | MOA: forms toxic free radicals in malarial food vacuole
Artemisinin
66
Anithelminthic that causes agranulocytosis
Mebendazole
67
Antimalaria drug MOA: ______ disrupts mitochondrial electron transport ______ inhibits folate synthesis
Atovaquone- | Proguanil
68
This drug should not be taken with milk because it will decrease the absorption
Doxycycline
69
DOC for whipworm infections
Mebendazole
70
Antihelminthic that increases membrane permeabilty to calcium leading to paralysis, vacuolization and death
Praziquantel
71
Malaria chemoprophylaxis | For P. Vivax and P. Ovale
Primaquine
72
Used to treat Advanced West African Sleeping Sickness (DOC)
Eflornithine
73
Antimalaria | MOA: forms electron-transferring redox compounds that act as cellular oxidants
Primaquine
74
P. Vivax and P. Ovale
Chloroquine then primaquine
75
This antimalaria drug causes folic acid deficiency
Pyrimethamine
76
MOA: complexes with DNA to prevent strand separation | Blocks DNA replication and transcription
Quinine
77
DOC: Cryptosporidium
Paromycin | Azithromycin
78
Chloroquine-sensitive P. Falciparum
Chloroquine
79
An antimaliarial drug that is also used for DMARDs - disease modifying anti-rheumatic drug MOA:prevents polymerization of heme into Hemozoin
Chloroquine
80
Anti-malarial drug that causes Cinchonism (headache, tinnitus, vertigo)
Quinine
81
DOC for strongyloidiasis
Ivermectin
82
Antihelminthic | MOA: uncouples oxidative phosphorylation or by acting ATPases
Niclosamide

Pharma PLE | Des (3 decks)

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