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Team decks > Open trials - past backup > Flashcards

Open trials - past backup Flashcards

1
Q

Which cancer is eligible for SARC 032?

A

soft tissue sarcoma of the extremity (resectable)

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2
Q

What is the drug studied and route of admin - SARC 032?

A

Pembro infusion

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3
Q

Is it comparator controlled, placebo controlled, etc. - SARC 032?

A

open label comparator - XRT/surgery (SOC) vs Neoadj. Pembro+XRT/Surgery/Adj. Pembro

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4
Q

SARC 032: Sponsor, PI, CRC - SARC?

A

Sarcoma Alliance (drug provided by Merck), Mo, Melanie

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5
Q

Which cancer is eligible for GemAcsorbate?

A

Unresectable soft tissue and bone sarcoma

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6
Q

What is the drug studied and route of admin - GemAscorbate?

A

Per 28 day cycle: Ascorbate - 6 infusions, Gemcitabine - 3 infusions

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7
Q

Is it comparator controlled, placebo controlled, etc. - GemAscorbate?

A

refer to protocol

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8
Q

GemAscorbate: Sponsor, PI, CRC - SARC?

A

IIT, Mo (Monga), Melanie

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9
Q

Which cancer is eligible for City of Hope?

A

Leiomyosarcoma and other soft tissue sarcomas

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10
Q

What is the drug studied and route of admin - City of Hope?

A

In 28 day cycle: Temozolomide chemo infusions day 1 - 5 + daily oral Cabozantinib

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11
Q

Is it comparator controlled, placebo controlled, etc. - City of Hope?

A

single arm: Temozolomide chemo (SOC) + daily oral Cabozantinib

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12
Q

City of Hope: Sponsor, PI, CRC?

A

City of Hope, Mo, Melanie

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13
Q

Which cancer is eligible for BOAST?

A

bone & soft tissue sarcoma (CDK)

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14
Q

What is the drug studied and route of admin - BOAST?

A

Daily oral Abemaciclib 2x per day

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15
Q

Is it comparator controlled, placebo controlled, etc. - BOAST?

A

single arm

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16
Q

BOAST: Sponsor, PI, CRC?

A

Medical College of Wisconsin, Mo, Melanie

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17
Q

MK3475: Sponsor, PI, CRC?

A

Merck, Mo, Melanie

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18
Q

Exelixis: Sponsor, PI, CRC?

A

Exelixis, Zakharia, Melanie

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19
Q

Genentech: Sponsor, PI, CRC?

A

Genentech, Mo, Teena

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20
Q

C4: Sponsor, PI, CRC?

A

C4, Mo, Teena

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21
Q

TTI-621: Sponsor, PI, CRC?

A

Trillium, Mo, Teena

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22
Q

GIST-PEAK: Sponsor, PI, CRC?

A

Cogent Biosciences, Mo, Melanie

23
Q

NeoDream/Philogen: Sponsor, PI, CRC?

A

Philogen, Mo, Melanie

24
Q

Fight209: Sponsor, PI, CRC?

A

Incyte, Mo, Teena

25
Q

Which cancer is eligible for MK3475?

A

“Advanced tumors” - extension trial, eligible if enrolled in prior pembro trial

26
Q

Which cancer is eligible for Exelixis?

A

nonresectable advanced melanoma

27
Q

Which cancer is eligible for Genentech?

A

NRAS-Mutant advanced melanoma

28
Q

Which cancer is eligible for C4?

A

synovial sarcoma (and others) - SMARCB1 perturbed

29
Q

Which cancer is eligible for TTI-621?

A

high grade leiomyosarcoma (not amenable to curative tx)

30
Q

Which cancer is eligible for GIST-PEAK?

A

GI stromal tumors (unresectable or mets)

31
Q

Which cancer is eligible for Neodream/Philogen?

A

melanoma (not yet reviewed)

32
Q

Which cancer is eligible for FIGHT-209?

A

recurrent glioblastoma or other CNS (FGFR1-3)

33
Q

What is the drug studied and route of admin - MK3475?

A

Pembro infusion Q3W (& combos based on prior studies)

34
Q

What is the drug studied and route of admin - Exelixis?

A

Pembro infusion Q3W & oral Cabozantinib daily

35
Q

What is the drug studied and route of admin - Genentech?

A

oral Belvarafenib, BID; oral cobimetrinib daily; Atezolizumab infusion Q4W

36
Q

What is the drug studied and route of admin - C4?

A

oral CFT8634

37
Q

What is the drug studied and route of admin - TTI-621?

A

Q3W: Doxirubicin chem infusion; TTI-621 infusion

38
Q

What is the drug studied and route of admin - GIST?

A

oral sutinib qd; CGT9486 (bezuclastinib) qd (without food)

39
Q

What is the drug studied and route of admin - Neodream/Philogen?

A

(not reviewed yet)

40
Q

What is the drug studied and route of admin - Fight-209?

A

oral Pemagatinib daily, 2 weeks on 2 weeks off

41
Q

Is it comparator controlled, placebo controlled, etc. - Fight-209?

A

single arm

42
Q

Is it comparator controlled, placebo controlled, etc. - NeoDream/Philogen?

A

(not yet reviewed)

43
Q

Is it comparator controlled, placebo controlled, etc. - GIST?

A

comparator: Sutinib vs sutinib + bexuclastinib

44
Q

Is it comparator controlled, placebo controlled, etc. - TTI-621?

A

?

45
Q

Is it comparator controlled, placebo controlled, etc. - C4?

A

single arm

46
Q

Is it comparator controlled, placebo controlled, etc. - Genentech?

A

comparator: Belvararafenib vs Bel+Cobimetinib vs. Bel+Cob+atelolizumab

47
Q

Is it comparator controlled, placebo controlled, etc. - Exelixis?

A

single arm?

48
Q

Is it comparator controlled, placebo controlled, etc. - MK3475?

A

extension trial - single arm

49
Q

Name Teena’s trials

A

Genentech, TTI-621, C4, FIGHT-209

50
Q

Name sarcoma trials:

A

SARC 032, GemAscorbate, City of Hope, BOAST, TTI-621, C4, GIST

51
Q

Name melanoma trials:

A

MK3475-587, Exelixis, Genentech, Neodream/Philogen

52
Q

Which one is Zakharia’s trial?

A

Exelixis

53
Q
A

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