Oncology Pharmacology Flashcards
Cytirabine- dose limiting toxicity
Cerebellar toxicity, needs to be checked every visit
Cisplatin/carboplatin case what HENT toxicity
Ototoxicity
Doxorubicin- toxicity
Cardiomyopathy
Vincristine/vinblastine toxicity
Peripheral neuropathy, autonomic instability, bowel paralysis
Common side effect from 5-fu
Mucositis, GI effects- diarrhea
Hemorrhagic cystitis caused by what agent
Iphosphamide
Cisplatin/carboplatin affects kidneys in what way
Nephrotoxicity, avoid NSAIDs, real predilection for renal failure
Taxane side effect
Peripheral neuropathy
Cancer that causes severe cold sensitivity
Oxaliplatin
What preventive intervention needs to be done for patients on cytarabine
Eye drops to prevent effect on eyes
Most common side effect from immune therapies
Rash, followed by diarrhea (usually after a month)
Patient on long acting and pen medications- pain still is 7-8/10; what should you change it to?
Add up total daily requirement- increase that by 50-100% and use that to make a long acting dose-> 10% of that dose for breakthrough
Why does fentanyl work so quickly
Very lipophilic and crosses BBB easily
What is fentanyl
Synthetic pure mu opioid agonist
What can increase absorption of fentanyl patch
Heat- avoid directly applying heating pads, electric blanktes
When converting from fentanyl to po, when to start long acting po
About 24 hours after taking off the patch because hte patch forms a reservoir of drug transdermally that will continue to release the drug
Appropriate disposal of fentanyl patch
Fold adhesive on self and flush down toilet
