Oncology Pharmacology

Question 1

Cytirabine- dose limiting toxicity

Answer 1

Cerebellar toxicity, needs to be checked every visit

Question 2

Cisplatin/carboplatin case what HENT toxicity

Answer 2

Ototoxicity

Question 3

Doxorubicin- toxicity

Answer 3

Cardiomyopathy

Question 4

Vincristine/vinblastine toxicity

Answer 4

Peripheral neuropathy, autonomic instability, bowel paralysis

Question 5

Common side effect from 5-fu

Answer 5

Mucositis, GI effects- diarrhea

Question 6

Hemorrhagic cystitis caused by what agent

Answer 6

Iphosphamide

Question 7

Cisplatin/carboplatin affects kidneys in what way

Answer 7

Nephrotoxicity, avoid NSAIDs, real predilection for renal failure

Question 8

Taxane side effect

Answer 8

Peripheral neuropathy

Question 9

Cancer that causes severe cold sensitivity

Answer 9

Oxaliplatin

Question 10

What preventive intervention needs to be done for patients on cytarabine

Answer 10

Eye drops to prevent effect on eyes

Question 11

Most common side effect from immune therapies

Answer 11

Rash, followed by diarrhea (usually after a month)

Question 12

Patient on long acting and pen medications- pain still is 7-8/10; what should you change it to?

Answer 12

Add up total daily requirement- increase that by 50-100% and use that to make a long acting dose-> 10% of that dose for breakthrough

Question 13

Why does fentanyl work so quickly

Answer 13

Very lipophilic and crosses BBB easily

Question 14

What is fentanyl

Answer 14

Synthetic pure mu opioid agonist

Question 15

What can increase absorption of fentanyl patch

Answer 15

Heat- avoid directly applying heating pads, electric blanktes

Question 16

When converting from fentanyl to po, when to start long acting po

Answer 16

About 24 hours after taking off the patch because hte patch forms a reservoir of drug transdermally that will continue to release the drug

Question 17

Appropriate disposal of fentanyl patch

Answer 17

Fold adhesive on self and flush down toilet