ONCOLOGY PART 1 Flashcards
What is the maximum dose of bleomycin?
400 units - lifetime cumulative
What is the maximum dose of doxorubicin?
450-500mg/m2 - lifetime cumulative
What is the maximum dose of cisplatin?
100 mg/ m2- per dose
What is the maximum dose of vincristine?
2 mg - single dose capped
Why is bleomycin dose limiting?
Pulmonary toxicity
Why is doxorubicin dose limiting?
Cardiotoxicity
Why is cisplatin dose limiting?
Nephrotoxicity
Why is vincristine dose limiting?
Neuropathy
What medications do not cause myelosuppression?
Asparaginase, bleomycin, vincristine
What medications have N/V as a common SE?
cisplatin, cyclophosphamide, ifosfamide
What medication have mucositis as a common SE?
fluorouracil, MTX
What medication has the common SE of diarrhea?
Irinotecan, capecitabine, fluorouracil MTX
What medications has the common SE of constipation?
Vincristine
What medication has the common SE of xerostomia?
caused by radiation
What medication can cause cardiomyopathy?
anthracyclines
What medications can cause QT prolongation?
Arsenic trioxide, many TKI
Which medications can cause pulmonary fibrosis?
Bleomycin, busulfan, carmustine, lomustine
Which medications can cause pneumonitis?
Maps (targeting CTLA-4 or PD-1)
Which medications have an increase risk of hepatotoxicity?
anti androgens (bicalutamide, flutamide, nilutamide)
Which medications have an increase risk of nephrotoxicity?
Cisplatin, and MTX (at high doses)
Which medications have an increase risk of peripheral neuropath?
Vinka alkaloids (end in tine), platinums, and taxanes
Which medications have an increase thromboembolic risk?
Aromatase inhibitors, SERMs
When does nadir occur?
7-14 days after chemotherapy
How fast to WBCs and platelets recover?
3-4 weeks post tx
