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NAPLEX Review > ONCOLOGY PART 1 > Flashcards

ONCOLOGY PART 1 Flashcards

1
Q

What is the maximum dose of bleomycin?

A

400 units - lifetime cumulative

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2
Q

What is the maximum dose of doxorubicin?

A

450-500mg/m2 - lifetime cumulative

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3
Q

What is the maximum dose of cisplatin?

A

100 mg/ m2- per dose

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4
Q

What is the maximum dose of vincristine?

A

2 mg - single dose capped

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5
Q

Why is bleomycin dose limiting?

A

Pulmonary toxicity

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6
Q

Why is doxorubicin dose limiting?

A

Cardiotoxicity

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7
Q

Why is cisplatin dose limiting?

A

Nephrotoxicity

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8
Q

Why is vincristine dose limiting?

A

Neuropathy

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9
Q

What medications do not cause myelosuppression?

A

Asparaginase, bleomycin, vincristine

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10
Q

What medications have N/V as a common SE?

A

cisplatin, cyclophosphamide, ifosfamide

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11
Q

What medication have mucositis as a common SE?

A

fluorouracil, MTX

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12
Q

What medication has the common SE of diarrhea?

A

Irinotecan, capecitabine, fluorouracil MTX

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13
Q

What medications has the common SE of constipation?

A

Vincristine

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14
Q

What medication has the common SE of xerostomia?

A

caused by radiation

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15
Q

What medication can cause cardiomyopathy?

A

anthracyclines

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16
Q

What medications can cause QT prolongation?

A

Arsenic trioxide, many TKI

17
Q

Which medications can cause pulmonary fibrosis?

A

Bleomycin, busulfan, carmustine, lomustine

18
Q

Which medications can cause pneumonitis?

A

Maps (targeting CTLA-4 or PD-1)

19
Q

Which medications have an increase risk of hepatotoxicity?

A

anti androgens (bicalutamide, flutamide, nilutamide)

20
Q

Which medications have an increase risk of nephrotoxicity?

A

Cisplatin, and MTX (at high doses)

21
Q

Which medications have an increase risk of peripheral neuropath?

A

Vinka alkaloids (end in tine), platinums, and taxanes

22
Q

Which medications have an increase thromboembolic risk?

A

Aromatase inhibitors, SERMs

23
Q

When does nadir occur?

A

7-14 days after chemotherapy

24
Q

How fast to WBCs and platelets recover?

A

3-4 weeks post tx

NAPLEX Review (1 decks)

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