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First Aid > Oncology (Leukemia/Lymphoma) > Flashcards

Oncology (Leukemia/Lymphoma) Flashcards

1
Q

Difference between CML and Leukemoid reaction

A

Rxn has low leukocyte alkaline phosphatase

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2
Q

Hodgkin’s lymphoma node presentation

A

Single, localized group of nodes with contiguous spread!

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3
Q

Non-Hodgkin’s node presentation

A

Multiple peripheral nodes with extranodal involvement and noncintiguous spread

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4
Q

Hodgkin’s smear findings

A

Reed-Sternberg cells

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5
Q

Non-Hodgkin’s smear findings

A

Most are B cell

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6
Q

Hodgkin’s lymphoma ages

A

Young adults and those > 55

More common in men except nodular sclerosing

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7
Q

Non-Hodgkin’s ages

A

20-40 years of age

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8
Q

HIV and immunosuppression are associated with this type of lymphoma

A

Non-Hodgkin’s

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9
Q

RS cells cytostain profile

A

CD15+
CD30+
B cell origin

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10
Q

Burkitt’s lymphoma demographics

A

Young adults

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11
Q

Burkitt’s genetics

A

t(8;14) of c-myc (8) and heavy chain Ig (14)

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12
Q

Burkitt’s genetics memory tool

A

B looks like 8
14 kitties
t(8;14) c-myc;Ig

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13
Q

Burkitt’s smearpearance

A

Starry sky with sheets of lymphocytes

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14
Q

Which lymphoma is associated with EBV?

A

Burkitt’s

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15
Q

Burkitt’s presentation locations

A

Africa: jaw
Sporadic: pelvis/abdomen

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16
Q

Diffuse large B-cell facts

A

MC adult NHL

Older adults

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17
Q

Mantle cell immunostains

A

CD5+

5 candles on my mantles

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18
Q

Mantle cell genetics

A

t(11;14) cyclin D1 and heavy Ig

turn of fire on mantle at 11:14 pm

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19
Q

Follicular lymphoma genetics

A

t(14:18) Ig and bcl-2

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20
Q

Adult T-cell lymphoma caused by

A

HTLV-1

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21
Q

Presentation of adult T-cell lymphoma

A

Cutaneous lesions
Japan, West Africa, Caribbean
Aggressive

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22
Q

Mycosis fungoides/Sezary presentation and stains

A

CD4+

Cutaneous patches and nodules (differentiate fromT-cell lymphoma by CD4)

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23
Q

Multiple myeloma pathogenesis

A

Plasma cell cancer arising in marrow and makes lots of IgG or IgA

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24
Q

MM presentation

A 
CRAB:
HyperCalcemia
Renal insufficiency
Anemia
Bone lytic lesions/Back pain
25
Q

Rouleaux smear indicates:

A

MM - RBCs stacked like poker chips (chains)

26
Q

How do you differentiate between multiple myeloma and Waldenstrom’s macroglobulinemia?

A

Waldenstrom’s lacks M spike and no bone lesions

Has hyperviscosity symptoms from IgM

27
Q

MGUS

A

M spike with no symptoms

28
Q

ALL age

A

< 15

29
Q

ALL labs

A

Inc. lymphoblasts on CBC

TdT+ (marks pre-t and B)

30
Q

ALL translocation w best prognosis

A

t(12;21) because ALL people love lunch time

31
Q

CLL age

A

> 60

32
Q

CLL smear

A

Smudge cells and AIHA

33
Q

Hairy cell leukemia stains and labs

A

TRAP+ !!!
Adults
B-cell

34
Q

hairy cell leukemia treatment

A

Cladribine (adenosine analog)

35
Q

AML age

A

65ish

36
Q

AML smear

A

Auer rods

37
Q

Which AML translocation responds to ATRA treatment

A

t(15;17)

38
Q

DIC is a common presentation of which leukemia

A

AML

39
Q

CML age

A

30-60

40
Q

CML translocation

A

cream cheese

t(9;22) bcr-abl

41
Q

CML

A

Inc. neutrophils

42
Q

CML blast crisis means

A

Transformed to AML or ALL

43
Q

CML labs

A

Very low alk phos

44
Q

CML treatment

A

Imatinib (bcr-abl inhibitor)

45
Q

What are auer rods?

A

Peroxidase positive inclusions seen in APL

46
Q

t(9;22)

A

CML bcr-abl

47
Q

t(8;14)

A

Burkitt’s c-myc

48
Q

t(11;14)

A

Mantle cell (cyclin D)

49
Q

t(14;18)

A

Follicular (bcl-2 activation)

50
Q

t(15;17)

A

APL (AML m3 type)

51
Q

Which chronic myeloproliferative disorder is the only JAK2 (-) one?

A

CML

52
Q

Which chronic myeloproliferative disorders are JAK2+?

A

PV
Essential thrombocytosis
Myelofibrosis

53
Q

PV classic presentation

A

Intense itching after a hot shower due to overactive hematopoiesis

54
Q

Essential thrombocytosis is what

A

Overstimulation of megakaryocytes specifically

55
Q

Myelofibrosis facts

A

Fibrotic obliteration of bone marrow leads to extramedullary hematopoiesis and teardrop cells (crying because left home)

56
Q

CML genetics

A

t(9;22) cream cheese

57
Q

High altitude causes this specific myeloproliferation

A

Appropriate absolute polycythemia vera

58
Q

Ectopic EPO is seen in these conditions

A

Renal cell carcinoma
Wims’ tumor
HCC

59
Q

Ectopic EPO causes:

A

Inappropriate absolute polycythemia

First Aid (4 decks)

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