Oncology Last Minute Reminders

Question 1

What is used for bladder cancer? MOA?

Answer 1

Enfortumab vedotin - ADC directed at nectin-4

Question 2

What is used for breast cancer? (8)

Answer 2

• CKD 4/6 inhibitors (-ciclibs)
• AI’s (anastrozole, letrozole, exemestane)
• GnRH agonist (goserelin acetate)
• HER2-TKI (Lapatinib, Tucatinib, Neratinib)
• PARP inhibitor (Olaparib)
• SERM (tamoxifen)
• Anti-HER2 MABs (pertuzumab, trastuzumab)
• ADC’s (trastuzumab + deruxtecan or emtasine)

Question 3

What is used for colorectal cancer? (2)

Answer 3

• VEGF inhibitor MAB (Bevacizumab)
• EGFR inhibitor MAB (Cetuximab, panitumumab)

Question 4

What do we use for endometrial cancer?

Answer 4

anti-HER2 MAB (transtuzumab)

Question 5

What do we use for kidney cancer?

Answer 5

VEGF-TKI (Note - multikinase) (Axitinib, Cabozantinib, Pazopanib, Lenvatinib, Sorafenib, sunitinib) - CLASPS

Question 6

What do we use for Leukemia?

Answer 6

BCR-ABL TKI (imatinib)

Question 7

What do we use for lung cancer?

Answer 7

• EGFR-TKI (Afatinib, Erlotinib, Gefitinib, Osimertinib*)
• ALK-TKI (Alectinib, Brigatinib, Certinib, Crizotinib, Lorlatinib)

*for T790M mutation

Question 8

What do we use for lymphoma?

Answer 8

anti-CD20 MABs (rituximab, obinutuzumab)

Question 9

What do we use for liver cancer?

Answer 9

VEGF-TKIs (sorafenib)

Question 10

What do we use for multiple myeloma?

Answer 10

proteasome inhibitors (Bortezomib, Carfilzomib, Ixazomib)

Question 11

what do we use for ovarian cancer?

Answer 11

VEGF inhibitors - bevacizumab
PARP inhibitors - olaparib, niraparib

Question 12

What do we use for prostate cancer?

Answer 12

• CYP17 inhibitors (abiraterone w/ prednisone)
• Androgen receptor blockers (Bicalutamide)
• GnRH antagonists (degorelix)
• GnRH agonists (leuprolide acetate, goserelin acetate)

Question 13

What do we use for skin cancer?

Answer 13

BRAF TKI and MEK TKI combo

Question 14

What do we use for stomach cancer?

Answer 14

Anti-HER 2 MABs (trastuzumab)

Question 15

What is enfortumumab vedotin used for? MOA?

Answer 15

Bladder cancer, ADC directed against Nectin-4

Question 16

What is abemaciclib used for? MOA?

Answer 16

early stage, Hormone +, HER2 - breast cancer in combo with endocrine therapy, CDK4/6 inhibitor.

Question 17

What are palbociclib and ribociclib used for? MOA?

Answer 17

advanced, hormone +, HER2 -, breast cancer in combo with aromatase inhibitors. CDK 4/6 inhibitors.

Question 18

Whare are anastrozole, letrozole, exemestane used for? MOA?

Answer 18

• early + advanced hormone + breast cancer.
• also used in endometrial + ovarian cancers.
• Aromatase inhibitors.

Question 19

What is goserelin acetate used for? MOA?

Answer 19

• in women, used for early + advanced breast cancer.
• in men, used for prostate cancer as: neoadjuvant or adjuvant tx w/ max duration of 3 yrs or tx of metastatic prostate cancer indefinetly.
• GnRH agonist.

Question 20

What are lapatinib and tucatinib used for? MOA?

Answer 20

• locally advanced unresectable or metastatic, HER2 + breast cancer.
• HER2 TKIss

Question 21

What is Neratinib used for? MOA?

Answer 21

• early stage and metastatic breast cancer (through pt access program)
• HER2 TKI

Question 22

What is olaparib used for? MOA?

Answer 22

• early stage breast cancer with BRCA mutation, HER2 -
• advanced BCRA mutated epithelial ovarian, fallopian, or primary peritoneal cancer as single agent maintenence in new diagnosed pts.
• relapsed, platinum sensitive, BCRA mutated epithelial ovarian, pallopian, or primary peritoneal cancer as maintenance.
• PARP inhibitor.

Question 23

What is tamoxifen used for? MOA?

Answer 23

• early and advanced hormone + breast cancer (as well as endometrial and ovarian)

Question 24

What is pertuzumab used for? MOA?

Answer 24

• advanced HER2 breast cancer (in combo w/ a taxane and trastuzumab)
• HER2 MAB

Question 25

What is trastuzumab used for? MOA?

Answer 25

- early stage and advanced HER2 + breast cancer. - advanced HER2+ endometrial cancer in combo with paclitaxel and carboplatin. - locally advanced unresectable or metastatic, HER2+ gastric cancer, GEJ, or esophagus. - HER2 MAB

Question 26

What are the trastuzumab ADCs? Uses?

Answer 26

- trastuzumab-deruxtecan - used for advancers HER2+ and HER2- low breast cancer - trastuzumab-emtasine - used for advanced HER2+ breast cancer and early stage HER2+ breast cancer as adjuvant tx.

Question 27

What is bevacizumab used for? MOA?

Answer 27

- locally advanced unresectable or metastatic colorectal cancer in combo w/ irinotecan or oxaliplatin-based chemo. also combo w/ trifluridine-tipiracil. - advanced ovarian, fallopian tube, or primary peritoneal cancer in combo w/ platinum and paclitaxel as a first-line tx, or for recurrent platinum resistant ovarian cancer. - VEGF MAB

Question 28

What are cetuximab and panitumumab used for? MOA?

Answer 28

- advanced NON-mutated RAS colorectal cancer - EGFR MAB

Question 29

What is sorafenib used for? MOA?

Answer 29

- advanced renal cell carcinoma - advanced liver cancer - VEGF-TKI (multikinase)

Question 30

What are axitinib, cabozantinib, pazopanib, lenvatinib, and sunitinub used for? MOA?

Answer 30

- advanced non-mutated RAS colorectal cancer. - VEGF-TKI (multikinase)

Question 31

What is imatinib used for? MOA?

Answer 31

- philadelphia chromosome+ acute lymphoblastic lymphoma and Ph+ chronic myeloid leukemia. - BCR-ABL-TKI

Question 32

What are afatinib, erlotinib, gefitinib, and osimertinib used for? MOA?

Answer 32

- advanced NSCLC, EGFR +. - Osimertinib for T790M Mutation - EGFR-TKIs

Question 33

What are alectinib, brigatinib, certinib, crizotinib, and lorlatinib used for? MOA?

Answer 33

- advanced NSCLC - ALK + - ALK-TKIs

Question 33

What are rituxumab and obinutuzumab used for? MOA?

Answer 33

- chronic-lymphocytic leukemia - non-hodgkin lymphoma - anti CD20 MABs

Question 34

What are bortezomib, carfilzomib, and ixazomib used for? MOA?

Answer 34

- multiple myeloma - proteasome inhibitors

Question 35

What is niraparib used for? MOA?

Answer 35

- advanced epithelial ovairan, fallopian tube, or primary peritoneal cancer as maintenance. - relapsed, platinum sensitive, epithelial ovarian, fallopian tube, or primary peritoneal cancer as single agent maintenance tx. - PARP inhibitor

Question 36

What is abiraterone used for? MOA?

Answer 36

- metastatic, castration-sensitive prostate cancer in combo w/ prednisone. - metastatic castration-resistant prostate cancer in combo w/ prednisone. - CYP17 inhibitor

Question 37

What is bicalutamide used for? MOA?

Answer 37

- prostate cancer - androgen receptor blocker (added to GnRH agonist to decrease flare when starting tx)

Question 38

What is degarelix used for? MOA?

Answer 38

- prostate cancer as: neoadjuvant and/or adjuvant tx w/ max duration of 3 years. - tx of metastatic prostate cancer. - GnRH antagonist.

Question 39

What is leuprolide acetate used for? MOA?

Answer 39

- prostate cancer as: neoadjuvant and/or adjuvant tx w/ max duration of 3 years. - tx of metastatic prostate cancer. - GnRH agonist.

Question 40

What are BRAF-MEK-TKIs used for?

Answer 40

skin cancer - BRAF mutation+ melanoma