oncology/gi/meds Flashcards
damage to the DNA of your cell
cancer
top cancers for women
breast
colon
lung
liver
top cancer for men
prostate
lung
liver
colon
controls growth cells
proto-oncogene
- mutated proto-oncogene
- uncontrolled cell growth
oncogene
slows down cellular division, cause cell death
tumor suppressor gene
uncontrolled cell growth
mutated tumor suppressor gene
resemble normal cell
less aggressive
typically benign
well differentiated
function more like normal cell
grow slower rate
well differentiated
do not resemble normal cell
aggressive
typically malignant
poorly differentiated
immature cells
lack structure/function
poorly differentiated
tumor cells grow only locally and cannot spread by unvasioin or metastasis
benign (non cancer)
cells invade neighboring tissue, enter blood vessels, and metastasize to different sites
malignant (cancer)
well differentiated cells
benign
usually localized effects
benign
(destruction) usually none unless flow impaired
benign
morbillity- minimal unless location interferes with vital function
benign
poorly differentiated cells
malignant
generalized: anemia, weakness, wt loss
malignant
often extensive; excretes toxins, uses up blood supply
malignant
high- unless growth and spread can be controlled/halted
malignant
“fingers” of cancer cells invade surrounding tissuw
locally invasive
malignant cells travel through blood or lymph system & invade other tissues or organs to form secondary tumor
metastasis
what are the common sites of metastases
lung
brain
liver
bone
what are the risk factors for cancer?
tobacco and smoking
diet and obesity
sedentary lifestyle
occupational exposure
family history
viruses
peritnatal factors/growth
alcohol
socioeconomic status
pollution
UV radiation
drugs and medical procedures
salt, food additives and contaminants
what is the hallmark of hereditary cancer syndrome?
-cancer in 2 or more relatives
-cancer in family member <50 years old
-same type of cancer in multiple family members
-rare type of cancer in 1 or more family members
- family members with more than 1 type of cancer
causes inflammation that can cause mutation
suppress the immune system
viruses
what are some virus examples that can turn into cancers?
HPV
Hepatitis B/Hepatitis C
Epstein-Barr
Human Herpes Virus 8
HIV
Helicobacter pylori
HPV
cervical cancer
Hepatitis B/Hepatitis C
liver cancer
Epstein Barr
Lymphoma
HIV
Lymphoma
Kaposi’s sarcoma
Helicobacter pylori
stomach ulcers
lymphoma in the stomach lining
-health promotions and illness prevention
-reduction of cancer mortality via reduction in the incidence of cancer
-lifestyle change, diet, adequate nutrients, avoiding alcohol, stress reduction
primary prevention
-screening (self breast and testicular exams)
-halt the progress of cancer through early screening and diagnosis
-targets to a specific cancer (pap smear, mammogram, colonoscopy, etc..)
secondary prevention
- disease treatment and rehabilitation
-health restoration
-prevent further deterioration
(chemotherapy, radiation, surgery,
-disease treatment
tertiary prevention
look for cancer before symptoms appear
- goal: find cancer in the early stages
screening
what are the types of screening?
-physical exam
-lab tests
-imaging procedures
-genetic testing
what age are the colorectal screening guidelines
beginning at 45 for both males and females
when should the fecal occult blood (FOBT)type be taken?
yearly
when should the flexible sigmoidoscopy be taken?
every 5 years
when should colonoscopy be given?
every 10 years
is colon cancer slow growing or fast growing?
slow growing
when should you start doing SBEs?
age 20+
at what age should breast exams be done by the HCP every 3 years?
age 40-44
at what age should HCP do breast exam and mammo yearly?
age 45-54
at what age should you go to see the HCP for a breast exam every 2 years?
age 55
when should pts go to the HCP if they are at high risk for cancer?
pts should go to the HCP to do MRI and mammogram yearly
what is the cervical screening?
pap smear
women should go to HCP within 3 years of initiating intercourse
what are the 7 warning signs of cancer?
-change in bowel or bladder habit
-a sore that does not heal
-unusual bleeding or discharge
-thickening or lump in breast or else where
-indigestion or difficult swallowing
-obvious change in a wart or mole
-nagging cough or hoarseness
pathologist compares the appearance of cancer cells to the normal surrounding cells
grading
classifying a malignancy by the extent of spread within the body
staging
who does the grading/differentiate?
pathologist
who does the staging?
oncologist
GX
can not be assessed
G1
(low grade):well differentiated, slow growing
G2
(moderate grade): moderately differentiated, growing slightly faster
G3
(high grade): poorly differentiated, growing faster
G4
(high grade):undifferentiated, not distinct at all, very aggressive
Stage 1
small cancer found only in organ where it originated
stage 2
larger cancer that may/may not have spread to the lymph nodes
stage 3
larger cancer also in the lymph nodes
stage4
cancer has spread from original site into other organs
what is the tnm system?
it is the staging process
what does t stand for?
t-size of primary tumor
what does the n stand for?
n- number of lymph nodes involved
what does the m stand for?
m- extent of metastasis
Tx
tumor size can’t be measured
T0
no primary tumor, or can’t be found
Tis
tumor is “in situ”
T1
small or early stage
T2
confined to original area
T3
has spread to surrounding tissues
T4
large, advanced stage cancer
what are the worse tumor sizes?
TX, T0, & T4
NX
nearby nodes can’t be tested/evaluated
N0
lymph nodes are cancer free
N1
cancer cells have reached one node
N2
cancer spread to more than one node
N3
cancer in lymph nodes extensive/widespread
M1
Cancer has spread to one or more distant part of the body
still in the original tissue layer
in situ
still in the original organ
localized
spread to nearby lymph nodes or organs
regional
spread to distant body parts
distant
what is the difference between in situ and localized?
in situ is only in one layer of the organ and localized is it is contained in one organ but in different layers
what are tumor markers used for?
monitor to see if body is responding to treatment
what are the different treatments for cancer?
surgery
radiation
chemotherapy
how long should pt wait for chemo if pt has had surgery? viseversa
4 weeks
what does chemotherapy do?
delay healing
most frequent treatment method
surgery
what can surgery be used in conjunction with chemo or radiation for?
prevent
diagnose
stage
treat
what are the types of surgery?
diagnostic
primary
prophylactic
palliative
reconstructive
shave off with blade
send off to lab
no sutures needed
shave biopsy
cylindrical blade goes deep into the different sub q layered tissue
closed with sutures
punch biopsy
affected tumor is large to remove so they do an incision
close with sutures, portion of the tumor is removed
incisional biopsy
30G needle aspirates tissue affected area, usually painless
fine needle
12G needle aspirates more tissue; very painful
core needle biopsy
remove as much of tumor as possible
debulking
can be disfiguring and alter function
radical excision
extensive surgery to site at which previous therapies have failed
salvage surgery
removal of non-vital tissue/organs that may develop cancer
prophylactic surgery
what are the considerations of prophylactic surgery?
-family hx and genetic predisposition
-presence or absence of symptoms
-risks vs benefirs
-ability to detect cancers early
-patients acceptance of post-op outcome
-no pain
-not intended to cure
-goal is high quality of life
-to alleviate disease without curing
palliative surgery
trying to repair injury or loss of function from curative or radical surgeries
-plastic surgery
-may take several procedures
reconstructive surgery
what should nurse do with surgical patient?
-incision care
-prevent infection
-manage pain
-educate on drains, infections, dietary intake to promote healing
what should surgical patients diet contain to promote healing?
protein and vitamin c
eliminate cancerous cells
-affects rapidly proliferating cells
radiation and chemotherapy
-uses energy to kill cells or shrink cells
-damage cell’s DNA
-damage healthy cell’s along the way
-treatment of choice for localized cancer
radiation therapy
how long is radiation given for?
over weeks
why is radiation given over weeks?
allows periphery of tumor to re-oxygenate and become more susceptible to radiation
dependent on presence of oxygen
radiosensitivity of the tumor
point at which normal tissues are irreparably damaged
normal tissue tolerance
total prescribed dose usually divided into several smaller doses
Treatments are usually given daily, 5 days per week for an average of 25 to 30 treatments
volume of tissue to be irradiated