oncology Flashcards
At what age should you be worried about T.21 “transient proliferative disorders” increasing chance of leukemia ?
3 years of age reminder TML–> PERIPHERAL blasts on cbc, low wbc, pancytopenia
How many blasts is diagnostic for leukemia ?
> 25%
Two areas “ extramedullary” where you can find leukemia ?
1) testes 2) cns (brain)
For leukemia ? is M > F? b cell > t cell long term or short term tx ? white disease or black disease ? age range?
male bcell long term 2-3 years white peaak 2-5 yr
What are poor prognostic fctors to ALL ?
-<1 yr or >10 -high WBC > 50 at dx -HYPERDIPLOIDY (ie. 12:31) TEL -MDR- response to first dose chemo -cure without the above is 90% (good)
What are the two most common ways to die in a leukemia emergency ?
1)respiratory failure 2) cns (bleed etc) others: sepsis, thus hydration is key
Main chemo for leukemia ?
-anthrocyclins -Vincristine -cyclophosphamide -steroids
what is the biggest side effect of radiation ?
-pulmonary fibrosis
About 10% of kids with congenital or acquired immunodeficiency develop NON HODKIDS LYMPHOMA ? true or false
true
ESOTROPIA AFTER 6 YEARS OF AGE is concerning for ???
POSTERIOR CEREBELLUM TUMOR ?
ct can frequently miss which area for lesions ?
-posterior fossa tumors ?
Whats is the most common extracranial solid tumor ?
neuroblastoma
AFP is to screen for what ? Whats specific tissue is it picking up ?
-hepatoblastoma ? -wilms -ectopic liver tissue
What location has the most missed bone tumors ?
pelvis - difficult to pick up
What class of chemo is worse for infertility ?
a) alkylators
What are the late effects of Cancers particular
hodkins lymphoma?
Think late effects of:
a) Radiation
b) steroids
c) Alykating chemo
d) Blemoycin
2) Anthrocyclins
