Oncology Flashcards
Hypertrophy
Growth in size
Hyperplasia
Growth in number
Cellular responses to DNA mutation
- apoptosis
- cellular repair back to normal
- no change; cell undergoes mitosis therefore passing mutation on to daughter cell —> cancer
Porto-oncogenes
Normal cell genes that promote normal cell processes
Oncogenes
Mutated cell genes
Benign cells: differentiation
Good- specific differentiated functions
Benign cells: growth
Continuous but orderly
Benign cells: migration
None
Benign cells: chromosomes
Normal
Malignant cells: differentiation
Poor; specific functions lost
Malignant cells: growth
Rapid/continuous
Malignant cells: migration
Yes
Malignant cells: chromosomes
Abnormal
Carcinomas: origin
Epithelial tissue
Adenocarcinoma : origin
Gland or organ
Sarcoma : origin
Mesenchymal tissue (bones and soft tissues)
Leukemia : origin
Hematopoietic stem cells
Myeloma : origin
Plasma cells
Lymphoma : origin
Lymph tissue
Stage I cancer
- cancer cells confined to 1 region
- only 1 lymph node involved
- asymptomatic
Stage II cancer
2 lymph node regions on same side of diaphragm
Stage III cancer
Lymph nodes or organs on both sides of diaphragm involved
Stage IV cancer
Cancer spread to multiple areas or organs OR Spread to distant lymph node OR Spread to bone marrow