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BTK Review 2024 > Oncology > Flashcards

Oncology Flashcards

1
Q

What is the target of trastuzumab?

A

Her-2/neu, a human epidermal growth factor receptor tyrosine kinase

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2
Q

What is the target of cetuximab?

A

EGFR

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3
Q

What is the target of imatinib?

A

c-kit, a stem cell growth factor receptor, implicated in GISTs

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4
Q

What is the target of ipilimumab?

A

anti-CTLA-4 to promote growth and function of T cells, mostly for melanoma

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5
Q

What is the target of nivolumab?

A

anti-PDL-1, removes checkpoint inhibition to allow T cells to function

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6
Q

What is the target of pembrolizumab?

A

anti-PD-1 receptor to remove checkpoint inhbition

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7
Q

Cisplatin’s main side effects are?

A

ototoxicity and nephrotoxicity

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8
Q

Bleomycin’s main side effect is?

A

pulmonary fibrosis

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9
Q

Doxorubicin’s main side effect is?

A

cardiotoxicity

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10
Q

Vincristine’s main side effect is?

A

peripheral neuropathy

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11
Q

Cyclophosphamide’s main side effect is?

A

hemorrhagic cystitis

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12
Q

What genes are involved in Lynch syndrome?

A

MSH2, MLH1, MSH6, and PMS2 (mismatch repair genes)

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13
Q

Lynch syndrome increases the risk of what cancers?

A

colon and endometrial mostly

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14
Q

What is APC?

A

a tumor suppressor gene that regulates intra-cytoplasmic pool of beta-catenin

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15
Q

What is Turcot syndrome?

A

a variant of Lynch syndrome or FAP that is associated with a brain tumor

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16
Q

What is Li Fraumeni syndrome?

A

a heritable cancer syndrome secondary to TP53 defect (a tumor suppressor gene)

17
Q

What is TP53?

A

a tumor suppressor gene associated with Li Fraumeni syndrome

18
Q

What is STK11?

A

a tumor suppressor gene associated with Putz-Jueger disease

19
Q

What are the screening recommendations for patients with BRCA mutations?

A
  • females: breast MRI annually starting at 25
  • males: annual breast exams
20
Q

What is CDH1?

A

a tumor suppressor gene associated with E-cadherin and hereditary diffuse gastric cancer

21
Q

What phase of cell division is most vulnerable to radiation treatment?

22
Q

What tumors are associated with the following tumor markers:
- CEA
- CA 19-9
- CA 125
- AFP
- LDH
- PSA
- Alk P
- Her-2
- Chromogranin

A
  • colon
  • hepatobiliary and pancreatic
  • ovarian
  • HCC and non-seminoma testicular
  • melanoma and testicular cancer
  • prostate
  • prostate
  • breast
  • carcinoid

BTK Review 2024 (19 decks)

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