Oncology

Question 1

Hodgkin’s lymphoma definition

Answer 1

Malignant proliferation of lymphocytes.

With the presence of Reed-Sternberg cells

Question 2

Hodgkin’s lymphoma histology classification

Answer 2

• Nodular sclerosing (most common): good prog.:more common in women || associated with lacunar cells
• Mixed cellularity: good prog. || asso. large no of reed-sternberg cells
• Lymphocyte predominat: best prog.
• Lymphocyte depleted (rare): worst prog.

Question 3

Hodgkin’s lymphoma poor prognosis factors

Answer 3

• B sx:
  o Night sweats
  o Weight loss >10% in last 6M
  o Fever >38C
• Other:
  o age > 45 years
  o stage IV disease
  ohaemoglobin < 10.5 g/dl
  o lymphocyte count < 600/µl or < 8%
  o male
  o albumin < 40 g/l
  o white blood count > 15,000/µl

Question 4

Hodgkin’s lymphoma RF + PX

Answer 4

RF
- HIV
- Epstein-Barr virus

PX
- Lymphadenopathy
o ~painless, non-tender, asymetrical
o Alcohol-induced lymphadenopathy pain

• Systematic B x
  o + pruritus
• **Other: mediastinal mass **
  o Sx i.e. cough or incidental CXR