oncology

Question 1

what is Folic acid antagonism?

Answer 1

because folic acids is needed to help cell divide through copying DNA, so the cell doesnt replicate/divde and eventually dies off

Question 2

what is Purine antagonists?

Answer 2

Interrupts metabolic pathways of purine nucleotides -> interrupts DNA/RNA synthesis -> tumour cells die

Question 3

what is pyrimidine antagonist?

Answer 3

interrupts metabolic pathways of pyrimidine bases -> interrupts DNA/RNA synthesis

Question 4

what are mitotic inhibitors?

Answer 4

works to slow down cell division and can work during any phase of mitosis

usually used for solid tumours or hematological malignancies

Question 5

what are topoimerase 1 inhibitors?

Answer 5

used to treat ovarian and colorectal cancer by inhibiting proper DNA function

Question 6

what is antineoplastic enzymes?

Answer 6

Synthesized using cultures of bacteria and recombinant DNA technology. can be used for all cancers

Question 7

what is Alkylating Drugs?

Answer 7

Used to treat various types of cancer by preventing cancer cells from reproducing

Question 8

what is cytotoxic antibiotics?

Answer 8

Natural substances produced by the mould Streptomyces (semi synthetics also used)
 Bone marrow suppression & HF is common with toxicity
 Mechanism of action: cell cycle non-specific and blocks DNA synthesis

Question 9

what are hormonal antineoplastics?

Answer 9

This therapy is used to
 oppose the effects of hormones.
 block the body’s sex hormone receptors

used for many cancers such as breast and prostate cancer

you would want to take baseline vitals before administering

Question 10

what are the 4 purines?

Answer 10

Adenine
Guanine
Hypoxanthine
Xanthine