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FINALS - 4th year > Oncology > Flashcards

Oncology Flashcards

1
Q

RF for developing N+V on chemo

A

anxiety // <50 // opioids // type of chemo

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2
Q

1st line anti-emetics low risk N+V patient

A

metoclopramide

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3
Q

1st line anti-emetics high risk N+V patient

A

5HT3 eg ondasetron (+ dexamethasone)

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4
Q

what type of meds are cyclophophamides and how do they work

A

alkylating agent - cross link DNA

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5
Q

SE cyclophophamides

A

haemorrhagic cystitis // myelosuppression // transitional carcinoma

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6
Q

what drug prevents haemorrhagic cystitis from cyclophophamides

A

Mesna

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7
Q

SE bleomycin

A

lung fibrosis

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8
Q

SE methotrexate

A

myelosuppression // mucositis // liver + lung fibrosis

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9
Q

se 5FU

A

myelosuppression, mucositis, dermatitis

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10
Q

SE cisplatin

A

ototoxic // peripheral neuropathy // low mg

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11
Q

what initial invx should all suspected cancer patients recieve

A

FBC // CXR // CT chest, abdo, pelvis // AFP + hCG

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12
Q

what tumour marker should men be screened for invx met of unknown origin

A

PSA

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13
Q

what tumour marker should women be screened for invx met of unknown origin + peritoneal malignancy or ascitic symptoms

A

Ca125

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14
Q

when is PET used

A

evaulate primary and metastitic disease - to see if legions are metabolically active

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15
Q

what cancer is Ca125 assoc with

A

ovarian + (liver)

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16
Q

what cancer is Ca199 assoc with

A

pancreatic + (liver) (+ cholangiocarcinoma)

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17
Q

what cancer is Ca153 assoc with

A

breast

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18
Q

what cancer is PSA assoc with

A

prostate

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19
Q

what cancer is AFP assoc with

A

hepatocellular + teratoma (+ testicular germ cell)

20
Q

what cancer is CEA assoc with

A

colorectal

21
Q

what cancer is aflatoxin ( from aspergillus) assoc with

A

liver

22
Q

what cancer is aniline dyes assoc with

A

bladder (transitional)

23
Q

what cancer is asbestos assoc with

A

mesothelioma + bronchial carcinoma

24
Q

what cancer is nitrosamines assoc with

A

oesophageal + gastric

25
Q

inheritance and mutation Li-Fraumeni syndrome

A

autosomal dominant, p53 suppressor

26
Q

cancer in li-fraumeni

A

sarcoma + leukemia

27
Q

diagnosis li-fraumeni

A

develop sarcoma under 45 // 1st degree FH cancer under 45 + another family malignacny under 45 or sarcoma at any age

28
Q

BRCA 1 + 2 cancer assoc

A

breast (60%) // ovarian (25%) // prostate

29
Q

lynch inheritance

A

dominant

30
Q

cancer with lynch

A

coloni or endometrial

31
Q

Amsterdam criteria for colorectal cancer

A

3 family members with colorectal (1 1st degree) // 2 generations // 1 diagnosis <50

32
Q

gardners inheritence

A

dominant

33
Q

cancers gardeners

A

colonic polyps

34
Q

most common mets –> bone

A

prostate –> breast – Lung

35
Q

most common place for bone –> mets

A

spine –> pelvis –> rib –> skull

36
Q

symptoms bone cancer

A

pain // fractures // hypercalcaemia // raised ALP

37
Q

subtypes of HPV –> cancer

A

16,18 (33)

38
Q

subtype of HPV –> warts

A

6+11

39
Q

HPV cell appearance

A

koilocytes –> enlarged nucleus, irregular membrane, dark nucleus

40
Q

what hormone is released in SSC lung cancer and what metabolic symptom

A

PTHrP –> hypercalcaemia

41
Q

what cancer is hypertrophic pulmonary osteoarthroplasty assoc with

A

SCC lung

42
Q

neoplastic spinal cord compression symptoms

A

back pain!!! worse lying down // LL weakness // sensory changes

43
Q

invx neoplastic spinal compression

A

MRI within 24 hours presentation

44
Q

mx neoplastic spinal cord

A

high dose oral dexa

45
Q

symptoms SVC obstruction

A

SOB // swelling // headache // visual disturbance // pulseless JVP

46
Q

causes SVC obstruction

A

small cell lung cancer // lympoma

FINALS - 4th year (9 decks)

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