Oncology

Question 1

Which tumour is associated with ‘Schiller Duval bodies’ and raised levels of serum alpha-fetoprotein (AFP)?

Answer 1

Yolk sac tumour

Question 2

What is tumour lysis syndrome?

Answer 2

Complication of chemotherapy (most common with lymphoma or leukaemia)
Can lead to AKI, arrhythmias, seizures
- hyperkalaemia
- hyperphosphotaemia
- hyperuricaemia
- hypocalcaemia

Question 3

Treatment of chronic myeloid leukaemia

Answer 3

Imatinib

Question 4

Side effect of cyclophosphamide (and it’s sister ifosfamide)?

Answer 4

Cause haemorrhagic cystitis, causing haematuria

Question 5

What is the MASCC risk index used for?

Answer 5

Multinational association of supportive care of cancer (MASCC) Risk index is used to predict risk of poor outcome in febrile neutropenia and whether in patient or outpatient is appropriate

Question 6

Signs of retinoblastic disease

Answer 6

Larger eye ( buphthalmos)
White opacity seen within the pupil with nil response to light
Excessive watering of the eye (epiphora) - this occurs due to increase in lacrimal pressure (due to buphthalmos) leading to regurgitation of fluid presenting as epiphora

Question 7

What virus is responsible for Kaposi sarcoma

Answer 7

Human herpes virus 8 (HHV-8) and HIV interaction