Oncology

Question 1

Side effect of anthracyclines (Doxorubicin)

Answer 1

Cardiomyopathy

Question 2

Side effect of Bleomycin

Answer 2

Lung fibrosis

Question 3

Fentanyl 75 patch equivalence in oral daily morphine

Answer 3

= 180mg oral morphine daily

Question 4

Fentanyl 100 patch equivalence in oral daily morphine

Answer 4

240mg oral morphine daily

Question 5

Fentanyl 12 patch equivalence in oral daily morphine

Answer 5

30mg oral morphine daily

Question 6

Buprenorphine 10 patch equivalence in oral daily morphine

Answer 6

24mg oral morphine daily

Question 7

Chemotherapy-induced vomiting - 1st line

Answer 7

Metoclopramide

Question 8

Chemotherapy-induced vomiting - 2nd line/high risk

Answer 8

Ondansetron + dexamethasone

Question 9

BRCA1 mutation - risk of breast cancer by age 70

Answer 9

55-65%

Question 10

BRCA2 mutation - risk of breast cancer by age 70

Answer 10

45%

Question 11

BRCA1 mutation - risk of ovarian cancer by age 70

Answer 11

40%

Question 12

BRCA2 mutation - risk of ovarian cancer by age 70

Answer 12

15%

Question 13

TTF-1 (thyroid transcription factor 2) stain common in which types of lung cancer

Answer 13

Adenocarcinoma or small cell carcinoma

Question 14

Commonest chemotherapy regime for small cell lung cancer

Answer 14

Etoposide + cisplatin

Question 15

Side effects of Cisplatin

Answer 15

Peripheral neuropathy
Hypomagnesaemia
Ototoxicity

Question 16

Which opioids are safe in CKD 4 and 5

Answer 16

Fentanyl
Buprenorphine
Methadone

Question 17

MOA of Bicalutamide in prostate cancer

Answer 17

Blocks testosterone (increased by Goserelin) - prevent tumour flare

Question 18

Anti-Yo antibodies are found in patients with which cancers

Answer 18

Bronchial carcinoma

Carcinoma of the breast