Oncogenes-gain of function due to mutation, need 1 damaged allele

Question 1

BCR-ABL

Answer 1

Abl-tyrosine kinase-mutated
Philadelphia chromosome
9, 22 translocation
Chronic myelogenous Leukemia (adults)
Acute Lymphocytic Leukemia (kids)

At 8, 144 I’ll Bcr-ABL to C and Meet Lucy in Philadelphia

Question 2

bcl-2

Answer 2

Mutated anti-apoptotic molec
Follicular B cell lymphoma
14, 18 translocation

Question 3

BRAF

Answer 3

Melanoma

Serine/threonine kinase mutated

Question 4

c-kit

Answer 4

GIST

mutated cytokine receptor for stem cells

Question 5

c-myc

Answer 5

Burkitt Lymphoma
mutated Transcription Factor
8, 14 translocation
starry sky appearance
B cells with irregular T cells reacting
EBV

Question 6

HER2/neu (c-erbB2)

Answer 6

Breast, ovarian, and gastric carcinoma cancer

receptor tyrosine kinase mutated

Question 7

L-myc

Answer 7

lung cancer (small cell)
mutated transcription factor

Question 8

N-myc

Answer 8

neuroblastoma

mutated transcriptiom factor

Question 9

ras

Answer 9

mutated GTPase

colon, pancreas, and lung cancer

Question 10

ret

Answer 10

MEN 2A

• medullary thryroid carcinoma (C cells-secrete calcitonin)
• pheochromocytoma
• parathyroid hyperplasia

and MEN2A

• Medullary thyroid carcinoma (C cells-secrete calcitonin)
• Pheochomocytoma
• Oral/intestinal ganglioneuromatosis
• Marfans-like

clusters of cancer
mutated receptor tyrosine kinase