Oncogenes and Tumor Suppressors

Question 1

BCR-ABL

Answer 1

tyrosine kinase
(X) CML
(X) ALL

Question 2

BCL-2

Answer 2

anti-apoptotic

(X) follicular lymphoma

Question 3

BRAF

Answer 3

Serine/Threonine kinase
(X) Melanoma
(X) non-Hodgkin lymphoma

Question 4

c-kit

Answer 4

cytokine R
(X) Gastrointestinal Stromal Tumor (GIST)

Question 5

c-myc

Answer 5

TF

(X) Burkitt Lymphoma

Question 6

HER2/Neu

Answer 6

Tyrosine Kinase
(X) Breast CA
(X) Ovarian CA
(X) Gastric CA

Question 7

L-myc

Answer 7

TF

(X) Lung tumor

Question 8

N-myc

Answer 8

TF

(X) neuroblastoma

Question 9

RAS

Answer 9

GTPase
(X) Colon CA
(X) Lung CA
(X) Pancreatic CA

Question 10

RET

Answer 10

Tyrosine Kinase
(X) MEN2A + 2B
(X) Medullary Thyroid CA

Question 11

APC

Answer 11

(X) FAP–> Colorectal CA

Question 12

BRCA1/BRCA2

Answer 12

DNA repair protein (tumor suppressor)
(X) Breast CA
(X) Ovarian CA

Question 13

DCC

Answer 13

Deleted in Colon CA (tumor suppressor)

(X) Colon CA

Question 14

DPC4/SMAD4

Answer 14

Deleted in Pancreatic CA (tumor suppressor)

(X) Pancreatic CA

Question 15

MEN1

Answer 15

Menin (tumor suppressor)

(X) MEN 1

Question 16

NF1

NF2

Answer 16

(tumor suppressors)
NF1= Ras GTPase activating protein (neurofibromin)
NF2= Merlin (schwannomin protein)
(X) NF 1 + 2 (respectively)

Question 17

p16

Answer 17

cyclin-dep kinase inhibitor 2A (tumor suppressor)

X) melanoma

Question 18

p53

Answer 18

TF for p21–/ G1–> S phase (tumor suppressor)
(X) Li Fruameni syndrome
(!) MOST ALL human CA

Question 19

PTEN

Answer 19

(X) BRCA
(X) endometrial CA
(X) prostate CA

Question 20

Rb

Answer 20

inhibit E2F –/ G1–> S phase (tumor suppressor)

(X) Retinoblastoma

Question 21

TSC1

TSC2

Answer 21

(tumor suppressor)
TSC1= Hamartin
TSC2=Tuberin
(X) Tuberus Sclerosis

Question 22

VHL

Answer 22

inhibit hypoxia inducible factor 1a (tumor suppressor)
(X) von-hippel landau disease
(X) Renal Cell CA

Question 23

WT1/WT2

Answer 23

(tumor suppressor)

X) Wilm’s Tumor (Nephroblastoma