oncogenes

Question 1

where do oncogenes derive from

Answer 1

normal regulatory genes, become oncogenes through mutations.

Question 2

are oncogenes recessive or dominant

Answer 2

dominant

Question 3

methods for oncogenes being pathogenic

Answer 3

produce too much protein, or produce super active protein.

Question 4

how do growth signals influence oncogenes.

Answer 4

oncogenes can bypass growth signals, to allow cells to prolierate without extrinsic factors.

Question 5

mechanism of activation of oncogenes

Answer 5

point mutation/deletion
chromosomal amplification- means lots more of it
chromosomal translocation
retroviral insertion- change reading frame.
retroviral transduction

Question 6

method of activation of oncogene involved in ras and raf

Answer 6

point mutation/deletion

Question 7

method of activation of oncogene involved in abl, myc and her2

Answer 7

gene amplification

Question 8

Ras

Answer 8

inner cell membrane surface. GTPase.

+ve growth regulator.

Question 9

mutations involved in ras

Answer 9

point mutations at 12,13,61