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STEP > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

ALK gene product + associated neoplasm

A

Receptor tyrosine kinase

Lung adenocarcinoma

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2
Q

HER2/neu (c-erbB2) gene product + associated neoplasm

A

Receptor tyrosine kinase

Breast and gastric carcinoma

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3
Q

RET gene product + associated neoplasm

A

Receptor tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

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4
Q

BCR-ABL gene product + associated neoplasm

A

Tyrosine kinase

CML, ALL

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5
Q

JAK2 gene product + associated neoplasm

A

Non receptor tyrosine kinase - STAT activation

Chronic myeloproliferative disorders

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6
Q

cMYC gene product + associated neoplasm

A

Transcription factor

Burkitt Lymphoma

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7
Q

MYCL1 gene product + associated neoplasm

A

Transcription factor

Lung cancer

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8
Q

MYCN gene product + associated neoplasm

A

Transcription factor

Neuroblastoma

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9
Q

BCL-2 gene product + associated neoplasm

A

Antiapoptotic molecule

Follicular and diffuse large B cell lymphoma

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10
Q

BRAF gene product + associated neoplasm

A

Serine/threonine kinase

Melanoma, non Hodgkin lymphoma, papillary thyroid carcinoma

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11
Q

cKIT gene product + associated neoplasm

A

Cytokine receptor

Gastrointestinal Stromal Tumour (GIST)

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12
Q

KRAS gene product + associated neoplasm

A

GTPase

Pancreatic, colon and lung cancer

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STEP (3 decks)

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