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High Yield > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

BCR-ABL

A

Oncogene

Philadelphia Chromosome

Tyrosine Kinase

9-22

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2
Q

BCL-2

A

Oncogene

Follicular Lymphoma

Anti-apoptotoic molecule

14-18

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3
Q

BRAF

A

Oncogene

Melanoma

Serine/threonien Kinase

Papillary too

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4
Q

C-kit

A

Oncogene

Gastrointestinal stromal tumor (GIST)

Cytokine receptor for stem cell factor

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5
Q

c-myc

A

Oncogene

Burkitt Lymphoma (8-14)

Transcription Factor

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6
Q

HER2/neu

A

Oncogene

Breast, ovarian and gastric carcinomas

Tyrosine kinase

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7
Q

L-myc

A

Oncogene

Lung tumors

Transcription factor

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8
Q

N-myc

A

Oncogene

Neuroblastoma –> irregular, firm, crosses midline (unlike nephroblastoma)

Transcription factor

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9
Q

RAS

A

Oncogene

Colon, lung, pancreatic

GTPase

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10
Q

Ret

A

Oncogene

MEN2A/B
MCT, papiallary thyroid

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11
Q

APC

A

Tumorsuppressor

Colorectal (FAP)

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12
Q

BRCA1

A

Tumorsuppressor

Breast and ovarain

DNA repair

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13
Q

BRCA2

A

Tumorsuppressor

Breast and Ovarian (male too)

DNA repair

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14
Q

CPD4/SMAD4

A

Tumorsuppressor

Pancreatic

DPC –> deleted in Pancreatic cancer

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15
Q

DCC

A

Tumorsuppressor

Colon Cancer

DCC –> deleted in colon cancer

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16
Q

MEN1

A

MEN type1

Tumorsuppressor

17
Q

NF1

A

Tumorsuppressor

RAS GTPase activating protein (Neurofibromin)

18
Q

NF2

A

Tumorsuppressor

Merlin (Shwannomin protein)

19
Q

p16

A

Tumorsuppressor

Melanoma

Cyclin dependent kinase inhibitor

20
Q

p53

A

Tumorsuppressor

Most cancers

Li-fraumeni –> SBLA Sarcoma, breast, lung, adrenal

21
Q

PTEN

A

Tumorsuppressor

Breast, prostate, endometrial

22
Q

Rb

A

Tumorsuppressor

Retinoblastoma, osteosarcoma

E7

Inhibits E2F

23
Q

TSC1

A

Tumorsuppressor

Tuberosclerosis

Hamartin

24
Q

TSC2

A

Tumorsuppressor

Tubero

Tuberin

25
Q

VHL

A

Tumorsuppressor

Inhibits HIF –> RCC (bilat), Hemangioblastomas in CNS, pheos

26
Q

WT1

A

Tumorsuppressor

Wilm’s tumor (nephroblastoma) Smooth unilateral, doesn’t cross midline (unlike neuroblastoma). WAGR

27
Q

WT1

A

Tumorsuppressor

Wilm’s tumor (nephroblastoma) Smooth unilateral, doesn’t cross midline (unlike neuroblastoma). WAGR

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