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step cards > onco/tumor suppressor genes > Flashcards

onco/tumor suppressor genes Flashcards

1
Q

ALK

A
  • RTK
  • lung adenoCA
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2
Q

EGFR (ERBB1)

A
  • RTK
  • lung adenoCA
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3
Q

HER2

A
  • RTK
  • breast & gastric CA
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4
Q

RET

A
  • RTK
  • MEN 2A & 2B, medullary & papillary thyroid CA, pheochromocytoma
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5
Q

BCR-ABL

A
  • non RTK
  • CML, ALL
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6
Q

JAK2

A
  • non RTK
  • myeloproliferative neoplasms
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7
Q

BRAF

A
  • serine/threonine kinase
  • melanoma, non Hodgkin, colorectal CA, papillary thyroid CA, hairy cell leukemia
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8
Q

c-KIT

A
  • cytokine receptor (CD117)
  • GI stromal tumor (GIST), mastocytosis
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9
Q

MYCC (c-myc)

A
  • transcription factor
  • Burkitt lymphoma
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10
Q

MYCN (n-myc)

A
  • transcription factor
  • neuroblastoma
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11
Q

KRAS

A
  • RAS GTPase
  • colorectal, lung, pancreatic CAs
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12
Q

BCL2

A
  • inhibits apoptosis
  • follicular & diffuse large B cell lymphomas
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13
Q

APC

A
  • neg regulator B-cat/WNT path
  • colorectal CA (associated w/ FAP)
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14
Q

BRCA1/BRCA2

A
  • breast, ovarian, prostate, pancreatic CAs
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15
Q

CDKN2A

A
  • p16, blocks G1 –> S phase
  • many cancers
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16
Q

DCC

A
  • colorectal cancer
17
Q

SMAD4 (DPC4)

A
  • pancreatic CA, colorectal CA
18
Q

MEN1

A
  • menin protein
  • MEN1
19
Q

NF1

A
  • neurofibromin protein
  • NF1
20
Q

NF2

A
  • merlin (schwannomin) protein
  • NF2
21
Q

PTEN

A
  • neg regulator PI3k/AKT path
  • prostate, breast & endometrial CAs
22
Q

RB1

A
  • inhibits E2F / blocks G1 –> S phase
  • retinoblastoma, osteosarcoma
23
Q

TP53

A
  • p53, activates p21, blocks G1–> S phase
  • most cancers
24
Q

TSC1

A
  • Hamartin protein
  • tuberous sclerosis
25
Q

TSC2

A
  • tuberin protein
  • tuberous sclerosis
26
Q

VHL

A
  • inhibits hypoxia inducible factor 1a
  • von Hippel Lindau disease
27
Q

WT1

A
  • urogenital development TF
  • Wilms Tumor (nephroblastoma)

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