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Rheum + Onco > Onco: Brands + Generics > Flashcards

Onco: Brands + Generics Flashcards

1
Q

Doxil

A

Doxorubicin (liposomal)
Class: anthracycline
MOA: ROS generator + DNA-binding

HAND-FOOT RASH (tx = urea-moisturizers)
*most common indication –> ovarian cancer

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2
Q

Cerubidine

A

Daunorubicin
Class: anthracycline
MOA: ROS generator + DNA-binding

NOT DaunoXome (daunorubicin liposomal)

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3
Q

Velban

A

VinBLAStine
Class: vinca alkaloid
MOA: alkylating agent

less peripheral neuropathy
(diarrhea)
more myelosuppression

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4
Q

Oncovin

A

VinCRIStine
Class: vinca alkaloid
MOA: alkylating agent

MORE peripheral neuropathy
(constipation)
less myelosuppression

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5
Q

Vidaza

A

Azacitidine
Class: anti-metabolite
MOA: cysteine analog
binds DNA methlyase –> inactivates –> apoptosis
(enters via equilibrative membrane transporter)

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6
Q

Imuran

Azasan

A

Azathioprine
Class: anti-metabolite
MOA: 6-MP pro-drug

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7
Q

Paraplatin

A

Carboplatin
Class: platinum analog
MOA: alkylating agent

MYELOSUPPRESSION (extensive!)

CALVERT EQ:
Dose (mg) = AUC * (GFR + 25mL/min)
max GFR to use is 125mL/min)

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8
Q

Platinol

A

Cisplatin
Class: platinum analog
MOA: alkylating agent

HIGHEST RATE: N/V, nephrotoxicity, ototoxicity (ear)
minimally myelosuppressive

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9
Q

Taxotere

A

Docetaxel
Class: Taxanes
MOA: microtubule inhibition

hypersensitivity +++
(some rash)

NO PVC BAGS
pGP substrate

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10
Q

Taxol

A

Paclitaxel
Class: Taxanes
MOA: microtubule inhibition

lacrimation, rash + erythema +++

NO PVC BAGS
pGP substrate

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11
Q

Abraxane

A

nab-Paclitaxel
Class: Taxanes
MOA: microtubule inhibition

peripheral neuropathy +++
(some rash)

NO PVC BAGS
pGP substrate

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12
Q

Idamycin

A

Idarubicin
Class: anthracycline
MOA: ROS generator + DNA-binding

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13
Q

Remicade

A

Infliximab
Class: monoclonal TNF-alpha Ab
MOA: binds soluble + membrane-bound TNF-alpha

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14
Q

Mutamycin

A

Mitomycin C
Class: antibiotic
MOA: ROA + DNAc crosslink generation (DUAL FX)

NO BBB
hepatic metabolism and renal elimination
HEMOLYTIC UREMIC SYNDROME
(p-GP)

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15
Q

Novantrone

A

Mitoxantrone

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16
Q

Blenoxane

A

Bleomycin

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17
Q

Alimta

A

Pemetrexed

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18
Q

Folotyn

A

Pralatrexed

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19
Q

Nexavar

A

Sorafenib

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20
Q

Sutent

A

Sunitinib

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21
Q

Kadcyla

A

ado-trastuzumab emtansine
Class:
MOA:

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22
Q

Herceptin

A

trastuzumab
Class:
MOA:

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23
Q

Alkeran

A

melphalan
Class: nitrogen mustard
MOA: alkylating agent

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24
Q

Leukeran

A

chlorambucil
Class: nitrogen mustard
MOA: alkylating agent

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25
Q

Myleran

A

busulfan
Class: nitrogen mustard
MOA: alkylating agent

26
Q

Cytoxan

A

cyclophosphamide
Class: nitrogen mustard
MOA: alkylating agent

27
Q

Neoral
Sandimmune
Restasis

A

cyclosporine

28
Q

DaunoXome

A

daunorubicin liposomal

NOT daunorubicin (Cerubidine)

29
Q

Paxil

A

paroxetine

SSRI + NOT a chemotherapeutic

30
Q

Ellence

A

epirubicin
Class: anthracycline
MOA: ROS generator + DNA-binding

31
Q

Halaven

A

eribulin
Class: anti-tubulin
MOA: binds b-tubulin –> promotes aggregation

minimal pGP substrate (vs. taxanes)…resistant tumors
“marine sponge”-derived

32
Q

Hydrea

A

hydroxyurea

33
Q

Lyrica

A

pregabalin

34
Q

Wellcovorin

A

leucovorin calcium

35
Q

Propacil

A

propylthiouracil

anti-thyroid agent

36
Q

Purinethol

A

mercaptopurine (i.e. 6-MP)
Class: purine analog
MOA: inactive purine analog

TMPT polymorphism (test required)

37
Q

Xeloda

A

capecitabine
Class: pyrimidine DNA analog
MOA: 5-FU prodrug (carboxyesterase activation)

HAND-FOOT
combine with leukovorin (improve efficacy)

38
Q

Xenical

A

orlistat

wt. loss medication

39
Q

Eloxatin

A

oxaliplatin
Class: platinum analog
MOA: alkylating agent

cold + chronic NEUROtoxicity

40
Q

Ifex

A

ifosphamide
Class: nitrogen mustard
MOA: alkylating agent

*CNS toxicity (not peripheral toxicity)
DRUNK (chloroacetaldehyde + acrolein)

41
Q

Adriamycin

A

doxorubicin (regular)
Class: anthracycline
MOA: ROS generator + DNA-binding

42
Q

Camptosar

A

irinotecan
Class: topoisomerase inhibitors
MOA: TOPO I inhibitor

Diarrhea: “I ran to the can”
UGT1A1 deficiency –> GILBERT’S SYNDROME (bilirubin metabolism disease)
SN-38 = active metabolite (3A4 metabolism)

43
Q

Granix

A

Filgrastim
Class: bone marrow stimulating factor

QD SQ dosing (used in prophylaxis and treatment)

44
Q

Neulasta

A

Pegfilgrastim
Class: bone marrow stimulating factor (long-acting)

Q12D SQ dosing (long-acting)
*cannot be used for prophylaxis

45
Q

Monoclonal Abs: “UMAB”

A

HUMAN antibody

i.e. penitumumab
LOWEST rate of infusion hypersensitivty rxns

46
Q

Monoclonal Abs: “ZUMAB”

A

humanIZED antibody

i.e. trastuzumab (Herceptin), Avastin

47
Q

Monoclonal Abs: “XIMAB”

A

chimeric mouse/human antibody

i.e. rituximab

48
Q

Monoclonal Abs: “OMAB”

A

MOUSE antibody

i.e. ibritumomab
HIGHEST rate of infusion hypersensitivty rxns

49
Q

Hypersensitivity Prophylaxis: Paclitaxel

A

diphenhydramine, ranitidine, dexamethasone
Brand = Taxol
NO PLASTIC

50
Q

Hypersensitivity Prophylaxis: Docetaxel

A

dexamethasone
Brand = Taxotere
NO PLASTIC

51
Q

Hypersensitivity Prophylaxis: Cabazitaxel

A

diphenhydramine, ranitidine, dexamethasone

NO PLASTIC

52
Q

Hypersensitivity Prophylaxis: Bevacizumab

A

NONE (no specific)

Brand = Avastin

53
Q

Hypersensitivity Prophylaxis: Trastuzumab

A

NONE (no specific)

Brand = Herceptin

54
Q

Hypersensitivity Prophylaxis: necitumumab

A

diphenhydramine

Brand = Dortazza

55
Q

Chloroacetaldehyde Antedote

A

Methylene blue

  • metabolite of ifosfamide (Ifex) breakdown (along with acrolein)
  • NOT affected by MESNA administration
  • causes “drunk” symptoms
56
Q

Carac

A

5-FU
Class: anti-metabolite
MOA: dysfunctional uracil analog (active capecitabine)

HAND-FOOT
combine with leukovorin (improve efficacy)

57
Q

Ara-C

A

Cytarabine
Class: anti-metabolite
MOA: inhibits Pol alpha + beta (potent)

ONLY ACTIVE IN S-PHASE
renal elimination
conjunctivitis + mental status exams
DRUNK (like ifosfamide)

58
Q

Gemzar

A

Gemcitabine
Class: anti-metabolite
MOA: inhibits Pol alpha + beta (potent)

active in ALL cell cycle phases
hepatic elimination
flu-like symptoms

59
Q

Two “drunk” cytotoxics:

A
  1. ) ifosfamide (Ifex): nitrogen mustard
    * *due to chloroacetaldehyde intermediate**
  2. ) cytarabine (Ara-C): purine analog
60
Q

Capostar: Diarrhea Tx

A

Irinotecan

Acute: SQ atropine
Delayed: 4mg loperimide (take @ first loose stool) + 2mg q2-4h until ≥12h w/o loose stool

Rheum + Onco (2 decks)

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