ONC207

Question 1

Neoadjuvant

Answer 1

− Refers to treatment prior to surgery

Question 2

Adjuvant

Answer 2

− Refers to treatment after surgery

Question 3

•ECOG

Answer 3

− Stands for Eastern Cooperative Group
− Score ranges from 0 – 5
∗ 0 = fully active
∗ 3 = limited self-care, confined to bed/chair more than 50% of time
∗ 5 = dead
− Can be used to help assess whether a given treatment is worth the risks/benefits or not

Question 4

• Karnofsky PS

Answer 4

− 100 = normal
− 50 = requires significant medical care
− 0 = dead

Question 5

When is therapy NOT recommended in metastatic patients?

Answer 5

when ECOG score is 3-4
OR
KPS score is

Question 6

does palliative care provide survival benefit similar to therapeutic intervention?

Answer 6

yes.

Question 7

List the types of systemic therapy in cancer

Answer 7

1) chemotherapy
2) endocrine therapy
3) targeted therapy
4) immunotherapy
5) radiopharmaceutical therapy

Question 8

what is the most common alkylating agent?

Answer 8

cyclophosphamide

Question 9

what is the mechanism of Cisplatin?

Answer 9

intercalating agent that crosslinks DNA to inhibit DNA repair/synthesis

Question 10

what are 3 intercalating agents?

Answer 10

1) cisplatin
2) carboplatin
3) oxaliplatin

Question 11

What is the mechanism of action of cyclophosphamide

Answer 11

alkylating agent: transfers an alkyl group to the purine base of DNA

Question 12

What are the toxicities of alkylating agents?

Answer 12

1) secondary malignancies

2) hemorrhagic cystitis

Question 13

What is the mechanism of action of the topoisomerase inhibitors?

Answer 13

prevent DNA uncoiling