Onc Stats

Question 1

EH without atypia:
- % progression over 20yrs?
- % spont regress over 2yrs?

Answer 1

-<5% progress
- 74% regress

Question 2

How often biopsy EH W/O atypia

Answer 2

6mly until x2 neg
or if bmi >35
or short course prog for >2yrs and annual review

Question 3

EH with atypia:
- % progress over 4yrs
- % progress over 20yrs

Answer 3

• 8%
  -27%

Question 4

EH with atypia;
- coexisting ovarian cancer %
- coexisting mets and death %

Answer 4

• 4%
• 0.5%

Question 5

BRCA 1
- breast cancer risk %
- ovarian cancer risk %

Answer 5

• 72%
• 44%

Question 6

BRCA 2
- breast cancer risk %
- ovarian cancer risk %

Answer 6

-69%
-17%

Question 7

RAD51C
- breast cancer risk %
- ovarian cancer risk %

Answer 7

• 21%
• 11%

Question 8

RAD51D
- breast cancer risk %
- ovarian cancer risk %

Answer 8

-20%
-13%

Question 9

MLH1
- endometrial cancer risk %
- ovarian cancer risk %

Answer 9

• 37%
  -11%

Question 10

MLH2
- endometrial cancer risk %
- ovarian cancer risk %

Answer 10

-48%
- 17%

Question 11

MSH2
- endometrial cancer risk %
- ovarian cancer risk %

Answer 11

-41%
-10%

Question 12

RRSO
- breast cancer risk reduction
-ovarian cancer risk reduction
Overall mortality reduction

Answer 12

-50% reduced
-80-96%
-60-77% mortality reduction

Question 13

Risk reduction for endometrial cancer
- exercise 20min 5/7
- bariatric surgery
- mirena
->5yrs COCP

Answer 13

-20-30%
-70-80%
-54%
-50%

Question 14

Recurrence of endometrial cancer if only had radiotherapy

Answer 14

18%

Question 15

Cancer pathway timings

Answer 15

Seen <14/7
Diagnosis <28/7
Treatment 62/7

Question 16

Lifetime risk ovarian cancer

Answer 16

2%

Question 17

Malignant germ cell and their hormones
1- immature teratoma
2- dysgerminoma
3- yolk sac
4- choriocarcinoma

Answer 17

1- increased LDH and aFP
2- increased LDH and hcg
3- increased aFP
4- increased hcg

Question 18

Sex cord tumour:
Granulosa cell and hormone

Answer 18

Increased inhibin B