Omeprazole (PPIs)

Question 1

What’s the mechanism of action of omeprazole?

Answer 1

Irreversible PPI, suppresses stomach acid secretion vie H+/K+/ATPase on parietal cells

Question 2

What condition(s) is omeprazole indicated in?

Answer 2

GORD, peptic ulcers, triple therapy for H. pylori infection

Question 3

Name some contraindications of omeprazole

Answer 3

• Diarrhoea from C.diff infection
• SLE
• Liver failure
• Osteoporosis

Question 4

Name some side effects of omeprazole

Answer 4

Diarrhoea, constipation, headache/dizziness, rash, increases the risk of C. diff-associated diarrhoea

Question 5

What drug increases the risk of C. diff-associated diarrhoea?

Answer 5

Omeprazole

Question 6

Name some drug interactions of omeprazole

Answer 6

Digoxin, clopidogrel, methotrexate, amoxicillin/clarithromycin/rifampin