Odontogenic Tumors and Cysts Flashcards
In Tjepkema JVD 2020, what is the most common location for conventional ameloblastoma? A) Caudal MX B) Rostral MX C) Caudal MN D) Rostral MN
Found mostly in region of canines and premolars of the maxilla - B
In Tjepkema JVD 2020, the percentage of intraosseous lesions of conventional ameloblastoma was \_\_\_, compared to \_\_\_ were extraosseous in CAA? A) 67%, 95% B) 33%, 67% C) 95%, 67% D) 95%, 33%
C)
CAA mostly extraosseous and most intraosseous are cystic.
Lower recurrence with conservative margins, margins of 1cm may not be necessary
In Fiani, odontogenic tumors and FFH, what were the most common lesions? A) FFH B) CAA C) POF D) APOT
B) CAA 45%>POF 31%>FFH 16%>APOT
In Fiani, odontogenic tumors and FFH, CAA was most common in the \_\_\_ and POF/FFH were most common in the \_\_\_? BONUS if you can state the ratio A) Rostral MX, Caudal MN B) Rostral MN, Caudal MX C) Rostral MX, Rostral MN D) Rostral MN, Rostral MX
D) CAA rostral MN (2.3:1)
POF/FFH rostral MX - POF (1.7:1)
According to Fiani, odontogenic tumors and FFH, which of the following is false?
A) Goldens, Akitas, Cockers and Shelties over-rep CAA
B) CAA equal between males and females.
C) FFH more common in mix breeds
D) APOT more common in the rostral MX
D) APOT in rostral MN
Neutered males over-rep in POF
Comparing Bellei and Babbitt, what are the percentage of DTC in their respective studies? A) 29%, 44% B) 39%, 77% C) 44%, 29% D) 77%, 39%
C) 44% Bellei, 29% Babbitt
Comparing Bellei and Babbitt, what are the percentage of unerupted teeth were PM1 in their respective studies? A) 78%, 68% B) 90%, 71% C) 68%, 78% D) 71%, 90%
A) Bellei 78% were PM1, 48.8% were cystic
Babbitt 68% were PM1, 29.4% were cystic
In Bellei, of the 10 teeth submitted for histo that were negative or equivocal for cystic lesions on rads, which of the following are true?
A) 4 lesions had pericoronal radiolucency that was <3x the width of the PDL and were DTC on histo.
B) 3 lesions had pericoronal radiolucency that was 3x the width of the PDL and were DTC on histo.
C) 3 lesions had pericoronal radiolucency that was <3x the width of the PDL and were not DTC on histo
D) All of the above.
D)
The point is that Babbitt said if the pericoronal lucency was greater than or equal to 3x the PDL you should extract because its likely a cyst. Bellei is saying they have several that are less than 3x that are still cystic so they are debunking this statement.
According to Babbitt, what breeds are over-represented in unerupted teeth?
Brachycephalics over-represented, Boxers, Bostons, Shih Tzu and Pug most common.
Bellei was Boxer and Lab
According to Babbitt, what was the percentage of histo diagnosed DTC's that were present in the 4 most common breeds? A) 85% B) 65% C) 45% D) 25%
A) 85% present in Boxers, Bostons, Shih Tzus and Pugs.
In Velasquez-Urgel, Maxillary and Mandibular POF in a cat, which of the following is false?
A) Odontogenic tumors represent 0.33% of oral tumors of the cat in one study, POF represented 7.8% of all oral tumors in another study,
B)Proliferative PDL stroma found as sole component in 16% of POF, while other POF contain odontogenic epithelium and/or foci of dentinoid, cementum or osteoid material
C) APOT originates with odontogenic epithelium with extracellular amyloid.
D) FIOT originates within the supportive CT with fibroblasts CT associated with islands of odontogenic epithelium and is noted most commonly in the rostral mandible.
D) FIOT, rostral maxilla
In Hodesson, features of squamous odontogenic tumor (SOT), which of the following were part of the defining features of the lesion? A) Lack of differentiated ameloblasts B) Squamous cell morphology C) Lack of signs of malignancy D) All of the above
D) is the answer
Lack of differentiated ameloblasts and signs of malignancy differentiate the lesion from ameloblastoma and SCC.
This case rostral mandible
According to Malmberg, AA with atypical foci in 5 dogs, which of the following is true?
A) Ancillary treatment was advocated
B) The atypical foci were associated with metaplasia and poorer prognosis relative to AA
C) No age, breed or sex predilection
D) Atypical cells were pleiomorphic with low mitotic rate.
C is true
No ancillary treatment was performed
The atypical foci were NOT associated with metaplasia or poorer prognosis relative to AA
Atypical cells had a high mitotic rate
According to Goldschmidt, clinical characterization of CAA in 263 dogs, which of the following is false?
A) CAA is typically found in middle aged-to geriatric dogs and Goldens have an increased propensity.
B) No difference noted between male and female patients
C) When narrown dirty margins encountered, revision surgery is warranted.
D) Intra-op margins of 1cm may be acceptable and margins for prevention of local recurrence may be as small as 5mm.
C) is false, when dirty margins are encountered, medical surveillance rather than revision surgery or radiation therapy may be clinically appropriate.
According to Goldschmidt, clinical characterization of CAA in 263 dogs, what was the most common location of CAA and what was its prevalence? A) Rostral MX, 21.5% B) Cadual MN, 21.5% C) Rostral MN 51% D) Caudal MX 51%
C) Rostral MN 51%
According to Tjepkema, suspected LPC in concurrently with CAA in a 2yo Std Poodle, which of the following is false?
A) LPCs are inflammatory cysts
B) LPCs are non-keratinized and associated with vital teeth.
C) Anatomically both LPC and CAA arise in the gingiva and periodontium expanding (LPC) or invading (CAA) along the affected tooth root while sparing the apex
D) LPCs present as a unilocular lucency with well defined corticated borders.
A) is False
LPCs are non-inflammatory, non-keratinized, developmental cysts that are associated with vital teeth lateral to a tooth root with absence of pulpitis, typically tear dropped shape
C) Describes possible association between LPC and CAA which may explain their existing together.
According to Tjepkema, suspected LPC in concurrently with CAA in a 2yo Std Poodle, LPC is assumed to originate from one of the following except? A) Reduced enamel epithelium B) Remnants of dental lamina C) Rests of Malassez D) Stellate reticulum
D) is false
According to Scott, Odontogenic fibromyxoma in the cat, where do these lesions originate from?
Originate from odontogenic ectomesenchyme, arise from connective tissue within tooth bearing regions.
According to Hoyer, Extensive Maxillary Odontomas in 2 dogs, odontomas which of the following is false?
A) Benign neoplasm
B) Comprised of mixed odontogenic epithelium and odontogenic ectomesenchyme
C) Never includes dental hard tissue
D) Hyperactivity of the dental lamina may be partially responsible for formation
C) is false in that these may or may not include dental hard tissue.
May be considered Hamartoma
Denticles pathognomonic for compound odontomas
According to Hiscox regarding peripheral giant cell tumor, which of the following is false?
A) Rostral maxilla is the classic location
B) Classically there is evidence of PDL
C) It is considered a reactive epulide
D) CT revealed expansile mass with osteolysis and periosteal reaction
B is false
Classically there is numerous GC, stellate mesenchymal cells with regularly spaced blood vessels and no evidence of PDL, which is a classic sign of a POF.
According to Honzelka, what modified conservative treatment was used on and extensive DTC?
Decompression by marsupialization by suturing cyst wall to oral mucosa, suture skin to any soft tissue around cyst and excision/enucleation at a later date.
According to Soukup and Bell's classification paper, which of the following are only present in animals? A) CAA B) APOT C) FIOT D) fibromatous epulides of PDL
All of them
According to Soukup and Bell’s classification paper, which of the following is true?
A) FFH is over exuberant repair of fibrous CT secondary to chronic gingival trauma and irritation
B) Most cases of CEOT analogous to humans
C) POF should be considered an inflammatory lesion of odontogenic mesenchyme
D) Amyloid in APOT is derived from odontoblasts
A is true
Most cases of CEOT not analogous to humans - APOT
POF should be considered a neoplastic lesion of odontogenic mesenchyme
Amyloid in APOT from ameloblasts
According to Svendius, oral path in Swedish dogs, which category of lesions was most common? A) Reactive B) Benign C) Malignant D) Unknown
Reactive at 39%, followed by Benign 24%, and malignant at 15%
According to Svendius, oral path in Swedish dogs, which lesion was most common? A) CAA B) POF C) FFH D) OMM
FFH was most common at 24%, followed by POF, then OMM
Purebred more prone, Dachshund predilection for malignancies
SCC lower than previous studies at 1.4%
Highest number of malignancies in Goldens, Labs and Dachshunds, Highest number of reactive lesions and benign in Goldens and Boxers (Boxers were biopsied most)
3 amelogenesis imperfecta Std Poodles identified.
According to LaDouceur regarding OKCs, which of the following is false?
A) OKCs are derived from odontogenic epithelium
B) They contain abundant orthokeratin and parakeratin
C) They are chronic inflammatory process that stimulate the rests of Malassez
D) Contain all characteristics of human OKCs except for microcyst formation.
C is false, its Rest of Serres (Dental Lamina Remnants)
According to Amory, CT characteristics of Odontogenic Neoplasms in Dogs, which are the following are associated with odontogenic tumors?
A) Displaced teeth
B) Cyst like structures
C) variable soft tissue and mineral attenuation
D) bone lysis and enhanced contrast
All of them
According to Amory, which of the following is best detected by dental radiology? A) keratinizing ameloblastoma B) conventional ameloblastoma C) CAA D) fibromatous epulides of PDL origin
D)
These are the only oral canine epulis recognized by WHO
According to Amory, CT characteristics of Odontogenic Neoplasms in Dogs, 52% of the maxillary masses had extraoral involvement, what structures was most commonly involved? A) nasal cavity B) orbit C) nasopharynx D) Vomer
A) Nasal Cavity 91%
53% of CAA cases in this study in rostral Maxilla
Rostral maxilla most common in all the cases (48.3%)
APOT 2/3rd rostral mandible
What are the four possible reasons deciduous teeth do not exfoliate (in McGee’s Bilateral DTC paper so that’s why its here)?
absent adult tooth
Ankylosis of deciduous tooth
hormonal influences
failure of permanent crown to contact deciduous root during eruption.
According to McGee, what tissue does a DTC arise from? A) enamel epithelium of a tooth crown B) epithelial rests of Malassez C) dental lamina remnants D) reduced enamel epithelium
D) REE
According to Verstraete Clinical and histo findings in dogs with odontogenic cysts, what percentage of lesions were DTC? A) 45% B) 71% C) 32% D) 16%
B) 29/41 dogs 71%, 36 cysts total
30 of 36 were PM1
Brachycephalics over-rep
According to Verstraete Clinical and histo findings in dogs with odontogenic cysts, 9/41 lesions resembled OKC with some but not all of the histo features to make diagnosis of OKC in humans. What breeds were over-represented in these lesions and what were they named?
Canine odontogenic parakeratinizing cyst
Over-represented by Min Schnauzer and Springer Spaniel
OKCs are developmental
COPC lack hyperchromatic, palisading basal cell layer and keratincious debris commonly found in OKC
According to Arzi, expression of cytokeratins in epithelium of canine odontogenic tumors, which of the following is true?
A) CK 8/18 expressed by CAA and POF but not normal tissue
B) Complex and compound odontomas had different expression than the tooth germ
C) Typical expression patterns of odontogenic epithelium and gingiva of dogs was CK 7, 8, 18 and 20
D) Dogs and man exhibit different expression in the odontogenic epithelium
A) is true
B) Compound and complex odontomas have nearly the same expression as the tooth germ
C) Typical expression patterns are CK 14 and CK 5/6.
CK 7, 8, 18 and 20 were generally absent
D) Dogs and man exhibit similar expression in the odontogenic epithelium
In Bock, Oral masses in 2 cats (APOT), which of the follwoing is false?
A) One APOT was ODAM (+) and one was ODAM (-) suggesting the amyloid in these lesions are of different origin
B) Amyloid in CEOT of humans associated with ODAM a unique odontogenic amyloid.
C) APOT differs from ameloblastoma because of stellate reticulum in APOT
D) APOT is a rare, benign, rapidly growing tumor
D) APOT is slow growing
According to Kelly, AA in dogs treated with intralesional bleomycin, which if the following is false?
A) All dogs had lesion decrease by 25% after the 1st injection.
B) Bleomycin causes vacuolar degeneration and tumor cell necrosis
C) Pulmonary fibrosis is a possible side effect of bleomycin and it was noted in 2/7 dogs
D) Complete response in 30-91 days in 6/7 dogs.
C is false, no dogs showed clinical signs of pulmonary fibrosis.
1/7 dogs was palliative and had ~25% decrease in tumor volume within 14 days.
According to Bell and Soukup regarding canine furcational cyst, which of the following were proposed mechanisms of inflammation? A) pericoronitis B) periodontitis C) trauma D) Developmental defects
All of them
According to Bell and Soukup regarding canine furcational cyst, which of the following was not a consistent radiographic feature?
A) Corticated border combined with a central area of increased radiolucency
B) Radiolucency of the furcation isolated within interradicular area between mesial and distal roots.
C) Expansion of cortical bone generally not seen
D) Evidence of endodontic disease
D no evidence of endodontic disease, impacted teeth, No obvious underlying causes for the cysts were identified.
TR in 4 of 20 (20%)
According to Bell and Soukup regarding canine furcational cyst, which of the following is false in regards to histologic findings?
A) Immature bone present in 65% of samples
B) Granulation tissue in 45%, present in all nine dogs that had attenuation or loss of the lining epithelium.
C) Inflammation ranged from minimal 15%, to moderate 25%, and was most commonly mild (60%).
D) Majority were non-viable teeth with evidence of pulpitis
D is false, vital tooth, no pulpitis
According to Bell and Soukup regarding canine furcational cyst, what was the most common skull type presented?
Mesaticephalic 70%, brachycephalic 25%, dolicocephalic 5%
