Odontogenic Cysts Flashcards
What is a cyst?
Pathological cavity that is fluid filled, semi filled or has gaseous contents and no pus (unless infected)
Do cysts have epithelial lining?
Majority except
NON ODONTOGENIC OTHER CYSTS:
SOLITARY BONE CYSTS
ANYEURYSMAL BONE CYST
What are the majority of cysts?
Odontogeic (>90%of cysts in OMFS region)
What is an odontigenic cyst?
Cyst that is related to dental apparatus and has dental origin
Where does the epithelial lining of odontogenic cysts arise from?
Rests of Malassez
Rests of serres
Reduced enamel epithelium
What are epithelial cell rests of Malassez?
Odontogenic epithelial cells located within the periodontal ligament matrix.
Remnants of odontogenic epithelium remain in the periodontal ligament !!!!
While their function is unknown, they may support tissue homeostasis and maintain periodontal ligament space or even contribute to periodontal regeneration.
How can an odontogenic cyst form from epithelial cell rests of mallasez?
During tooth development there is inner and outer enamel epithelium which grows downwards forming epithelial root sheath of Hertwig which outlines TOOTH SHAPE AND FORMATION OF HARD TISSUE
Once root forms no need for this epithelium anymore and it normally degredades and dissolves but in some cases clumps of epithelial cells remain in PDL which remain static (they are vital but not active) and can be triggered to switch on (inflammation) resulting in cyst
What are rests of serres?
These are remnants of dental lamina epithelium entrapped within the gingiva.
How can odontogenic cyst form from rest of serres?
These are remnants of the dental lamina that once tooth formation is complete they are no longer needed and break up and disintegrate but in some cases they remain In jaw bones resulting in cysts
What is reduced enamel epithelium?
The epithelial covering of the enamel after its formation is completed.
How can reduced enamel epithelium lead to cyst formation?
After tooth formation when tooth is UE, the inner and outer enamel ep of tooth germ come close to each other forming reduced enamel ep which covers crown of UE tooth and as tooth pushes to erupt it breaks up but reduced enamel ep can be source of cyst
DENTIGEROUS CYST
What are the most common odontogenic cysts?
Radicular cysts (residual cysts) - 60%
Dentigerous cysts (eruption cysts) - 18%
Odontoegnic keratocysts - 12%
What is a radicular cyst?
This is an odontogenic inflammatory cyst associated with a NON VITAL TOOTH
What teeth are radicular cysts associated with?
non vital teeth
How can we be more inclined a cyst is radicular?
if tooth is grossly carious, likely non vital then consider this
Why do radicular cysts arise?
Tooth is non vital, necrotic products from pulp break down exist tooth at apex resulting in inflammation which can trigger cyst (inflammation can cause cells to activate)
When are radicular cysts most common in presentation?
4-5th decade - most common for caries and non vital teeth
Do radicular cysts affect males and females?
yes equal rates
Where do majority of radicular cysts occur?
60% maxilla
40% mandible
How might a pt present with radicular cyst? 6
Often asymptomatic
Pain (if secondarily infected)
Swelling (often buccal) - gradual expansion as slow growing)
Dislodgement of adjacent teeth (tooth may change position)
Pressure, numbness, altered sensation - if in region of nerve canal (IANC, mental nerve)
Tooth mobility
Do radicular cysts grow fast?
No, often slow growing and can grow for Long time to become large (have limited expansion)
What may a radicular cyst be rather than cyst?
Periapical granuloma
What is a PA granuloma?
A periapical granuloma is a relatively common lesion or growth that develops around the tip of a tooth’s root. It consists of a proliferating mass of granulation tissue (new tissue that forms on a wound) and bacteria that forms in response to dead tissue in the pulp chamber of the tooth.
How can we tell if its PA granuloma of radicular cyst?
Look at SIZE OF LESION!!
>15mm then 2/3rds are radicular cyst
How can we get radicular cyst?
Pulp necrosis –> PA periodontitis –> PA granuloma –> radicular cyst
What are the radiographic features of radicular cysts? 6
Well defined margins
Rounded shape
Radiolucent
Corticated margin of radiolucency that continuous with the Lamina dura - if we can follow the corticated margin with LD its good indication
If large it displaces structures
Resorption of root unlikely unless long standing then external root resorption
What is a good radiographic indication its a radicular cyst?
continuous with the lamina dura of tooth and corticated margin
Describe the histology of a radicular cyst
Fibrous CT wall and lined epithelium (stratified squamous ep, non-keratinised)
Can contain cholesterol in fluid due to RBC breakdown
How can radicular cyst develop from granuloma (histology)?
This is due to epithelial cell rest of malassez which is present in the PDL, the tooth is non vital and there is necrotic debris which can activate these cells due to inflammation and they begin to divide within the granuloma resulting in centre of granuloma becoming cut off from blood supply –> necrosis –> cyst forming
Why do majority of cysts grow at same rate?
Path of least resistance of growth
Osmosis - centre of cell draws in water by osmosis which causing pressure on surrounding bone resulting in resorption of bone and cyst continues to grow (activation of osteoclasts)
What are the two ways radicular cysts form?
Epithelium proliferates in granuloma resulting in central necrosis due to lack of blood supply
Epithelium surrounds fluid area
Why can we get egg shell crack on palapation of a radicular cyst?
Cyst has thinned cortical bone and when we feel it it will crack slightly
What can radicular cyst do to cortical plate?
Thin and displace it
If we were removing a cyst why do we want a CBCT?
We want to see buccal/lingual expansion and proximity to important nerve structures - if layer of bone separating then theres a protection of nerve
Why is a rounded well formed lesion a good sign?
Good sign cyst isn’t nasty! if cancer then often grows fast, fast eating of bone
What can give moth eaten appearance to bone?
Osteomyelitis
What is osteomyelitis?
(which is infection and inflammation of the bone marrow, sometimes abbreviated to OM)