Ocular Circulation Flashcards

1
Q

What’s the principle function of the choroid?

A

To nourish the outer 1/3 of the retina

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2
Q

What are the other functions of the Choroid?

A

Absorb excess light from RPE, contribute to Bruch’s membrane, provide protective canal for vessels and nerves (suprachroidal space), stabilizes ocular temperature

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3
Q

What are the 3 layers of vessels in the choroid?

A

Choriocapillaris (inner), Sattler’s Layer (middle), Haller’s Layer (outer)

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4
Q

What size are the vessels of the choriocapillaris? What type of vessels are they?

A
  • small (40-60microns)

- fenestrated

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5
Q

What size are the vessel of Sattler’s Layer? What type of vessels are they?

A
  • medium vessels

- nonfenestrated Vessels

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6
Q

What size are the vessels of Haller’s layer? Where can we find this layer?

A
  • large vessels

- Part of choroidal stroma

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7
Q

What can we find in Haller’s Layer?

A

The 4 vortex veins

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8
Q

What are the main functions choriocapillaris?

A

Supplies nutrients and blood, removes waste from outer retina and macular region.. has a relationship with RPE and Bruch’s membrane

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9
Q

How many layers are found in the choriocapillaris region?

A

Single layer of broad capillaries

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10
Q

The choriocapillaris is internal to ______ layer and external to _____ _____.

A

Sattler’s Layer, bruch’s membrane

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11
Q

Which layer contains the largest capilalries of the eye and allows passae of multiple RBCs without damage?

A

Choriocapillaris

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12
Q

What are the 3 sources of chroidal blood supply?

A

Short cililary arteries, long ciliary arteries and anterior ciliary arteries

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13
Q

The posterior pole develops the _____

A

ora serrata

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14
Q

What is the gradient of development for the layers of the choroid?

A

Choriocapillaris develops first&raquo_space; Sattlers Layer&raquo_space; Hallers Layer

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15
Q

RPE induces _____ in the choroid.

A

angiogenesis

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16
Q

Development of choroidal vasculature depends on what?

A

The presence of differentiated RPE and production of inductive signals

17
Q

Neural Ectoderm develops into?

A

Basement membrane of RPE which secretes bruch’s membrane

18
Q

Mesodermal Mesenchyme develops what?

A

Endothelium of BV and Blood elements of the choroid

19
Q

Neural Crest develops what?

A

Melanocytes, Fibrocytes and smooth muscle of blood vessles

20
Q

Hard drusen are found what kind of RPE?

A

Thinned but Intact RPE

21
Q

What are the generalizations of Soft Drusen?

A
  • localized RPE detachments
  • More likely to have vision loss
  • High risk for Wet ARMD
22
Q

Angioid Streaks represent breaks where? What are the other generalizations?

A

In bruch’s membrane

There will be radiating lines from optic disc (looks like a cracked sidewalk)

Possible choroidal neovascularization

23
Q

The choroid supplies the _____ of the retina, and the CRA supplies the _____ of the retina

A
Choroid = outer 1/3
Retina = Inner 2/3
24
Q

The Central Retinal System has and inner capillary plexus that is found in what layer? What is another name for this plexus?

A

Ganglion Cell Layer

Superficial Capillary Plexus

25
The Central Retinal System has and outer capillary plexus that is found in what layer? What is another name for this plexus?
Inner Nuclear Layer | Deep Capillary Plexus
26
What is the outer location of the blood retinal barrier?
Tight junctions near the apical side of the RPE "outer" closer to the choroid
27
What is the inner location of the blood retinal barrier?
Nonleaky Tight junctions joining endothelial cells of retinal blood vessels "inner" closer to the vitreous
28
Which ocular tissue has the greatest blood flow (even more than the brain and kidneys)?
Choroid
29
True or False: Retina has autoregulation and Choroid does not?
True. The choroid does not have the ability to maintain blood flow with increased ocular pressure or lack of nutrients
30
Intraocular pressue will mostly effect blood flow from which ocular tissue the most?
Greatest effect - Choroid The higher the pressure, moderate increments in pressure reduce blood flow
31
Automatic Innervation is found in which ocular tissues?
Choroid, CB and Iris NOT RETINA
32
Autoregulation is found in which ocular tissues?
CB, Iris and Retina
33
What is the rate of flow in the choroid and retina, respectively?
``` Choroid = 667 Retina = 31 ```