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Neuro Journal Club > October 13 Journal Club > Flashcards

October 13 Journal Club Flashcards

1
Q

Neurotrophin family of growth factors

A
  • NGF
  • BDNF
  • NT-3
  • NT 4/5
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2
Q

TrkA

A

Responds to NGF

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3
Q

TrkB

A

Responds to BDNF and NT4/5

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4
Q

TrkC

A

NT-3

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5
Q

p75

A

Structurally unrelated receptor (unrelated to TrkA, B, or C) which can function alone or together with the Trk receptors to modulate neuronal responses to target derived neurotrophins. all neurotrophins bind to p75.

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6
Q

Signaling Endosome

A

Model in which neurotrophins and Trk receptors in distal axons are internalized as ligand-receptor complexes into an endocytic signaling platform. These are retrogradely transported along microtubules back to neuronal cell bodies where they signal to control transcriptional events.

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7
Q

2 functions of target-derived neurotrophins

A
  1. Regulation of neuronal survival

2. Axon growth

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8
Q

NGF

A

Controls terminal arborization of peripheral neurons.

Expressed in peripheral targets innervated by sympathetic and sensory neurons.

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9
Q

Ngf/Bax double mutant mice

A
  • Elimination of Bax + NGF allows assessment of NGF functions in axon growth without apoptosis that would be elicited by NGF deprivation.
  • Reduction of sympathetic and sensory innervation of several target tissues was observed in these mice.
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10
Q

CREB

A

cAMP-responsive element binding protein, a transcription factor that is necessary and sufficient to support the survival of neurotrophin-dependent neurons, and also mediates axon growth in response to NGF.

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11
Q

NFAT

A

Nuclear factor of activated T cells, exclusively required for neurotrophin-dependent axon growth

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12
Q

SRF

A

Serum response factor, exclusively required for neurotrophin-dependent axon growth

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13
Q

Early growth response 3

A

Egr3, exclusively required for neurotrophin-dependent axon growth

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14
Q

Wnt5a

A

A member of the Wnt family that is upregulated by target-derived NGF in developing sympathetic neurons.

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15
Q

Genes regulated by NGF-dependent signaling that promote axon growth and innervation of final target tissues

A
  • NGF receptor
  • TrkA
  • NGF itself
  • cytoskeletal components including alpha-tubulin, beta-actin, and gamma-actin
  • regulators such as Rho-specific GEFs
  • Trio
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Neuro Journal Club (2 decks)

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