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Pharmacology > OCD > Flashcards

OCD Flashcards

1
Q

These help controls OCD symptoms where dopamine agonist can worsen symptoms

A

Serotonergic reuptake inhibitors

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2
Q

This is classified separately from anxiety disorders.

A

OSC

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3
Q

this dysfunction is also associated with OCD

A

Dysfunction of the cortico-thalamo-cortical circuit

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4
Q

Symptoms of OCD

A

obsessions and compulsion

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5
Q

Anxiety-provoking unwanted and repetitive thoughts, images or urges that are difficult to control

A

Obsessions

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6
Q

Repetitive behaviours to reduce anxiety

A

Compulsions

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7
Q

Goals of therapy

A

Reduce the incidence and intensity of obsessions
Reduce the time spent acting on compulsion
Optimize patient functioning and quality of life
Prevent recurrence of symptoms
Treat comorbidities
Minimize side effects of txt
Induce remission (long-term goal)

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8
Q

Diagnostic criteria as per DSM-5

A
  1. Presence of obsessions/compulsion
  2. Patient has recognized that such behaviours are excessive/unreasonable
  3. Behaviours are causing distress, are time-consuming, and are intereferring with daily activities
  4. Behaviours are not due to substance abusing or medical conition
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9
Q

Causes of OCD

A

Medical conditions and drugs

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10
Q

What are the medical conditions that causes OCD?

A 
History of head injuries
neurocognitive disorders (alzheimer's, parkinsons)
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11
Q

What are the drugs that causes OCD?

A

stimulants (cocaine)
dopamine agonist (pramipexole, ropinirole)
SGAs (olanzapine)

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12
Q

What are the risk factors that causes OCD?

A 
Age
social isolation
history of physical abuse
negative emotionally
family history (genetic component)
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13
Q

Possibel non-pharmacological options to treat OCD:

A
  1. Cognitive behavioural therapy (CBT)
  2. Exposure and response preventions (ERP)
  3. rTMS (repetitive transcranial magnetic stimulation)
  4. Deep brain stimulation
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14
Q

Is the 1st line non-pharmacological therapy to txt mild to moderate OCD with or without pharmacotheraphy?

A

CBT

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15
Q

For how long the benefits of CBT remains?

A

1-5 yrs

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16
Q

This non-pharmacological therapy is a specialized type of CBT for OCD and it is commonly practiced?

A

ERP

17
Q

This non-pharmacological therapy involves magentically stimulating certain areas of brain and can be considered in refractory OCD

A

rTMS

18
Q

This non-pharmacological therapy involves in insertion of a small neurostimulator into a targeted brain area and can be considered in refractory OCD?

A

Deep brain simulation

19
Q

This is the 1st line pharmacological therapy to treat OCD?

A

SSRIs

20
Q

What are the some examples of SSRIs:

A 
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
sertraline
21
Q

This is the 2nd line pharmacological therapy to treat OCD?

A

Citalopram
venlafaxine
clomipramine
mirtazapine

22
Q

These drugs can be more effective than SSRIs for comorbid pain/comorbid major depressive disorder:

A

Clomipramine and venlafaxine

23
Q

This drug has similar effectiveness to SSRIs in OCD but has lower tolerability due to anticholinergic and antihistaminic effects. ANd it should be taken with food

A

Clomipramine

24
Q

This drug causes significant weight gain but has lowr risk of sexual dysfunction

A

mirtazapine

25
Q

What are the 1st line pharmacological AUGMENTATIVE txt options?

A

SGAa as augmentative

26
Q

Examples of SGAs

A

Aripiprazole

risperidone

27
Q

2nd line pharmacological AUGMENTATIVE txt options?

A

Memantine
Quetiapine
topiramate

28
Q

3rd line of pharmacological AUGMENTATIVE txt options?

A 
Olanzapine
amisulpride
ziprasidone
haloperidol
mirtazzapine
celecoxib
granisetron
IV ketamine
ondansetron
N-acetylcysteine
riluzole
lamotrigine
29
Q

Natural health products to treat OCD?

A

Milk thistle
Valerian root
St.John’s wort

30
Q

This natural health product to treat OCD can cause serotonergic activity and may cause serotonin syndrome when administered with other SSRIs?

A

St.John’s wort

31
Q

This drug is linked with fetal cardiovascular malformations

A

paroxetine

32
Q

Recommended txt for OCD in preganancy, breastfeeding and pediatric pts?

A

CBT is 1st line

33
Q

Recommended txt for OCD in preganancy if symptoms are severe?

A

SSRIs

Pharmacology (4 decks)

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