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Pharm 1 > Obstructive lung disease medications > Flashcards

Obstructive lung disease medications Flashcards

1
Q

Corticosteroids MOA

A

In mast cells: inhibit phospholipase A2 which decreases leukotriene and prostaglandin synthesis
Inhibit Th2 cells: decrease IL-4 and IL-5 which decrease mast cell and eosinophils

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2
Q

Inhaled corticosteroids

A

Beclomethasone
Budesonide
Ciclesonide
Mometasone
Fluticasone
Triamcinolone

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3
Q

Systemic corticosteroids

A

Hydrocortisone
Prednisone
Prednisolone
Methylprednisolone

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4
Q

Mast cell stabilizers MOA

A

Inhibit the release of prostaglandins and leukotrienes

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5
Q

Mast cell stabilizer drugs

A

Nedocromil
Cromolyn

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6
Q

Leukotriene receptor antagonists MOA

A

bind and block leukotriene receptors in smooth muscles
Decrease smooth muscle contraction, mucus secretion, and inflammation

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7
Q

Leukotriene receptor antagonists

A

Montekukast
Zafirlukast
both oral

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8
Q

Leukotriene synthesis inhibitor MOA

A

Inhibits 5-lipoxygenase which stops leukotriene synthesis from arachidonic acid
Effective in preventing exercise or aspirin induced asthma

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9
Q

Leukotriene synthesis inhibitor drugs

A

Zileuton

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10
Q

Anti-Ige Monoclonal antibody

A

Bind to IgE antibodies so they can’t stimulate FceR1 receptors and activate mast cells which prevents inflammatory mediator production

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11
Q

B2 Agonists MOA

A

Bind to beta2 receptors and activates adenylyl cyclase to increase cAMP production and relax smooth muscle
Can stimulate receptors on mast cells and decrease the release of inflammatory mediators

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12
Q

SABA drugs

A

Albuterol
Metaproterenol
Terbutaline

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13
Q

LABA drugs

A

Salmeterol
Formeterol

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14
Q

Muscarinic antagonists MOA

A

Bind to M3 muscarinic receptors and blocks acetylcholine leading to less smooth muscle contraction

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15
Q

Muscarinic antagonist drugs

A

Ipatropium bromide (short acting)
Tiotropium bromide (long acting)

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16
Q

Methyxantines MOA

A

Enter smooth muscle in respiratory tract and inhibits PDE which increase cAMP in cell and causes smooth muscle relaxation. Blocks adenosine receptors through the body

17
Q

Methylxantine drug

A

Theophylline

Pharm 1 (5 decks)

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