Obstetrics Pt.3 Flashcards
How is Rubella spread?
Why is its perinatal infection uncommon?
- Togavirus spread by droplet transmission
- Very uncommon in the UK thanks to MMR
Describe Rubella screening
- Prevalence of rubella has reached such low levels in the UK that screening is NO LONGER ROUTINELY OFFERED
- For women who are screened and rubella antibody is NOT detected, they should be offered the MMR after pregnancy
- NOTE: the vaccine itself is contraindicated in pregnancy because it is a live vaccine
What are the clinical features of Congenital Rubella Syndrome?
- Sensorineural deafness
- Congenital cataracts
- Blindness
- Encephalitis
- Endocrine problems
What is the risk of CRS?
- The risk of CRS decreases with gestation and the manifestations are less severe
- Rubella infection before 11 weeks has 100% risk of CRS
- Rubella infection > 20 weeks has no risk of CRS
What is the management of CRS?
- If infection during pregnancy is confirmed, risk of CRS should be assessed
- If it has occurred < 16 weeks, termination of pregnancy should be offered
What is Syphilis and its clinical features?
- Caused by Treponema pallidum
Clinical Features
- Painless genital ulcer 3-6 weeks after infection is acquired (condylomata lata)
- NOTE: this may be on the cervix and hence go unnoticed
- Secondary manifestations occur 6 weeks to 6 months after infection with a maculopapular rash or lesions affecting the mucous membranes
- If untreated, some will develop symptomatic cardiovascular tertiary syphilis and some will develop neurosyphilis
- In pregnant women with early, untreated syphilis, most infants will be infected and 25% will be stillborn
What are the risks of syphilis in pregnancy?
- FGR
- Foetal hydrops
- Congenital syphilis (may cause long-term disability)
- Stillbirth
- Preterm birth
- Neonatal death
- IMPORTANT: adequate treatment with benzathine penicillin markedly improved the outcome for the foetus
Describe Syphilis Screening in pregnancy
- Routine antenatal screening is offered for ALL pregnant women
- Treponemal antibodies are detected in serology
- Non-treponemal tests detect non-specific treponemal antibodies
- Venereal disease research laboratory (VDRL) test
- Rapid plasma reagin test (RPR)
- NOTE: they have a high false-positive rate
- Treponemal tests detect specific treponemal
- EIAs
- Very sensitive and specific
- Treponema pallidum haemagglutination assay (TPHA)
- Fluorescent treponemal antibody-absorbed test (FTA-abs)
- EIAs
- IMPORTANT: none of these tests will detect syphilis in the incubation stage
What is the management of syphilis in pregnancy?
- Confirm the diagnosis and test for other STIs
- GUM clinic should initiate appropriate contact tracing
- Parenteral penicillin (benzathine penicillin) has a 98% success rate at preventing congenital syphilis
- A Jarish-Herxheimer reaction may occur with treatment as a result of the release of proinflammatory cytokines in response to dying organisms
- Causes worsening of symptoms and fever for 12-24 hours after starting treatment
- May be associated with uterine contractions and foetal distress
- So, women may be admitted during treatment for monitoring
- If the woman is NOT treated during pregnancy, the baby should be treated after delivery immediately
What is Toxoplasmosis?
- Caused by Toxoplasma gondii which is a protozoan found in cat faeces, soil or uncooked meat
- 1/3 of people in the UK are probably infected with Toxoplasma at some point in their lives
Is toxoplasmosis screening offered?
- NOT offered routinely because it is very rare for babies to be affected
- Little evidence for the benefits of screening
What is some advice about toxoplasmosis prevention?
- Avoiding eating rare or raw meat
- Avoiding handling cats and cat litter
- Wearing gloves and washing hands when gardening or handling soil
What are the clinical features of toxoplasmosis?
How does foetal damage and transmission rate change during pregnancy?
- Initial infection is usually ASYMPTOMATIC or may cause flu-like illness
- Parasitaemia occurs within 3 weeks
- Infection in the first trimester is most likely to cause severe foetal damage but the transmission rate is low (10%)
- In the third trimester, the transmission rates are much higher (85%) but the risk of foetal damage is low (10%)
What are the features of Severely Affected Infants of Toxoplasmosis?
- Ventriculomegaly
- Microcephaly
- Chorioretinitis
- Cerebral calcification
- NOTE: most infants are asymptomatic at birth and develop symptoms later on
What is the management of toxoplasmosis?
`- Diagnosis is made by the Sabin Feldman Dye Test
- NOTE: IgM antibody tests are also available but IgM may persist for months or years after infection
- If an abnormal US raises suspicion of congenital toxoplasmosis, amniocentesis can be performed
- PCR of amniotic fluid is highly accurate for identification of T. gondii
- Spiramycin treatment can be used in pregnancy (3 week course of 2-3 g/day)
- This reduces incidence of transplacental infection
- If toxoplasmosis is found to be the cause of abnormalities on ultrasound, termination of pregnancy should be offered
What is cytomegalovirus?
- CMV is a DNA herpes virus transmitted by the respiratory droplet route and excreted in the urine
- 60% of women are seropositive for CMV when they become pregnant
- 1-2 out of 200 infants in the UK are born with congenital CMV
- Some will have problems at birth (e.g. hearing loss, learning difficulties) and others will be asymptomatic but go on to develop problems later on
- Primary infection is more likely to cause congenital CMV
What are the clinical features of cytomegalovirus?
- Primary infection usually produces no symptoms or mild flu-like symptoms in the mother
- Diagnosis is usually made after abnormalities are seen on the ultrasound
- Features in the foetus
- Growth restriction
- Microcephaly
- Intracranial calcification
- Ventriculomegaly
- Ascites
- Hydrops
- Infants may present later with blindness, deafness or developmental delay
- The neonate can also be anaemic and thrombocytopaenic with hepatosplenomegaly, jaundice and a purpuric rash
What is the management of CMV?
- Serological diagnosis (CMV antibodies in an initially seronegative woman)
- NOTE: IgM can persist for several months so IgM is insufficient to diagnose infection, it has to be a new finding in a woman who was IgM negative at the time of booking
- The amniotic fluid can be tested by PCR
- If abnormalities suggestive of congenital CMV are detected, termination of pregnancy should be discussed
- CMV is a herpes virus, so it can be latent and be reactivated
- It persists in the lymphocytes throughout life
- Reactivation occurs via shedding in the genital, urinary or respiratory tract
What virus causes chickenpox?
What can chickenpox cause?
- Caused by varicella zoster virus (VZV) which is transmitted by droplets and direct personal contact
- Screening is NOT routinely recommended
- Women identified as being seronegative can be considered for vaccination either prepregnancy or in the postnatal period
- It can cause foetal varicella syndrome
What are complications of chickenpox in pregnant women?
- Pneumonia
- Hepatitis
- Encephalitis
- Non-immune pregnant women are more vulnerable to complications of chicken pox
- The mortality rate is 5 times high in pregnant women compared to non-pregnant adults
What is the advice for pregnant women regarding chickenpox?
- Asked whether they have had chickenpox before at the booking visit
- If NOT, be advised to avoid contact during pregnancy
- If they do come into contact with chickenpox, they should seek medical advice ASAP
- Significant contact is defined as being in the same room as someone for 15 mins or more, or face-to-face contacts
- Individuals with the virus are infectious 48 hours prior to the appearance of the rash until the vesicles crust over (around 5 days)
- VZV IgG can be detected to confirm VZV immunity
How should non-immune women with chickenpox be managed?
- Given VZIG as soon as possible
- It is effective when given up to 10 days after contact
- Women should be advised to inform the doctor if a rash develops
How is chickenpox in pregnancy managed?
- Avoid contact with other pregnant women and neonates until the lesions have crusted over
- Aciclovir 800 mg 5/day for 7 days should be prescribed if they present within 24 hours of the onset of the rash and they are > 20 weeks gestation
- VZIG has NO therapeutic benefit once chickenpox has developed
- Hospital admission should be considered if the following risk factors are present: smoking, chronic lung disease, corticosteroids or in latter half of pregnancy
- Women who are hospitalised should be nursed in isolation from babies and pregnant women
- Delivery during the viraemic period may be EXTREMELY HAZARDOUS
- Patients should be given supportive treatment with IV aciclovir
What are the risks of chickenpox in pregnancy?
- Thrombocytopaenia
- DIC
- Hepatitis
- Varicella infection of the newborn
What is Congenital Varicella Syndrome?
- Characterised by one or more of the following:
- Skin scarring in a dermatomal distribution
- Eye defects (microphthalmia, chorioretinitis, cataracts)
- Hypoplasia of the limbs
- Neurological abnormalities (microcephaly, cortical atrophy, mental restriction and dysfunction of bowel and bladder sphincters)
- This occurs in a minority of infected foetuses (1%)
- No cases have been reported if maternal infection has occurred after 28 weeks
- If the mother has contracted chickenpox during the pregnancy, referral to foetal medicine specialist should be considered at 16-20 weeks or 5 weeks after infection for discussion and detailed ultrasound examination
- NOTE: 5 week time lag is required as it takes time for features to manifest
How should maternal infection around the time of delivery be managed?
- Significant risk of varicella of the newborn
- Elective delivery should be avoided until 5-7 days after the onset of the rash to allow time for passive transfer of antibodies to the foetus
- Neonatal ophthalmic examination done after birth
- If birth occurs within 7 days of the onset of the rash or the mother develops chickenpox within 7 days of delivery, the neonate should be given VZIG
- The infant should be monitored for signs of infection until 28 days after the onset of maternal infection
- Neonatal infection should be treated with aciclovir
Is contact with shingles a problem?
- Low risk of a non-immune pregnant woman getting chickenpox from someone with shingles
What is parvovirus infection and how is it transmitted?
What percentage of women are immune?
Is screening recommended?
- Caused by parvovirus B19 which is transmitted through respiratory droplets
- 50% of women of child-bearing age are immune and 50% are susceptible
- Routine screening is NOT recommended
What are the clinical features of parvovirus?
When is the foetus most vulnerable?
What are complications of the virus and how is this investigated?
- Asymptomatic or cause a mild flu-like illness and/or arthropathy
- In children it causes slapped cheek syndrome (aka fifth disease, erythema infectiosum)
- Foetus is most vulnerable in the second trimester
- In most foetuses infected with parvovirus, there will be spontaneous resolution with no long-term sequelae
- However, the infection can cause aplastic anaemia
- The anaemic foetus could be come hydropic due to high output cardiac failure and liver congestion
- Seen on ultrasound (high velocity in the foetal middle cerebral artery suggests anaemia)
How is parvovirus diagnosed?
When is foetal loss due to virus higher?
How is the virus managed?
- Diagnosed by serology in mother (development of IgM antibodies to Parvovirus B19) having previously tested negative
- PCR of virus in maternal and foetal serum/amniotic fluid is the most accurate test
- A hydropic foetus may recover spontaneously or may require in utero transfusion
- Infection in the first 20 weeks can lead to hydrops fetalis and intrauterine death (intrauterine transfusion is not possible at early gestations)
- Foetal loss rate is much higher (10%) in the first 20 weeks
- If the anaemia is treated by in utero transfusions, the foetus can make a complete recovery
- Parvovirus does NOT cause neurological damage so if they survive the anaemia the outcome is usually normal
What is Listeria?
Where does it originate?
- Caused by Listeria monocytogenes which is an aerobic and facultatively anaerobic motile Gram-positive bacillus
- It is an obligate intracellular parasite
- People with reduced cell-mediated immunity (i.e. pregnant women) are most at risk
- Incidence of Listeria infection in pregnant women is 18 x higher than in the non-pregnant population
- Usually comes from contaminated food, most commonly:
- Unpasteurised milk
- Ripened soft cheeses
- Paté
- Listeria does NOT survive in cooked or frozen food but can survive in refrigerated food (e.g. milk, soft cheese, prawns)
What are the clinical features of Listeria?
How does transmission to the foetus occur?
What are Listeria complications in pregnancy?
- Flu-like illness with fever and general malaise
- 1/3 of women will be asymptomatic
- Transmission to the foetus can occur via:
- Ascending route through the cervix
- Transplacental
- 20% of affected pregnancies result in miscarriage or stillbirth
- 50% result in premature delivery
- 38% neonatal mortality (due to respiratory distress, fever, sepsis or neurological symptoms)
What is the management of Listeria?
- Diagnosed by isolation of the organism from blood, vaginal swabs or the placenta
- Meconium staining of amniotic fluid may raise suspicion
- IV antibiotics (AMPICILLIN 2 g every 6 hours)
What is Malaria?
Which pregnant women have increased risk of malaria?
Why may the parasite be missed in blood films?
- Plasmodium falciparum carries the worse prognosis for mother and foetus
- Most common in sub-Saharan Africa
- Pregnant women have an increased risk of infection (especially if primiparous)
- The parasite can sequestrate in the placenta (and be missed by blood films)
What are the clinical features of Malaria?
- Pyrexia
- Associated with miscarriage and preterm labour
- Hypoglycaemia is common and may be severe in pregnancy
- Pulmonary oedema can occur (high mortality)
- Jaundice
- Renal failure
What are the effects of Malaria on the foetus?
- Preterm delivery
- FGR
- Higher rate of HIV transmission
What is the management of Malaria?
- Symptomatic and supportive treatment
- Antimalarials (depends on drug resistance and local patterns of disease)
- Pregnant women planning to travel to endemic areas should be counselled about insecticides, mosquito nets and appropriate clothing
Describe herpes in pregnancy
- This is DANGEROUS if acquired around the time of delivery
- Double-stranded DNA virus
- Neonatal herpes has a high morbidity and mortality
- It occurs due to contact with infected secretions
What are the clinical features of herpes?
What are the subgroups of neonatal herpes?
- Genital herpes causes ulcerative lesions on the vulva, vagina and cervix
- Primary infection is usually more severe and can cause systemic symptoms and urinary retention
- Neonatal herpes can be caused by HSV1 and HSV2
- Neonatal herpes has THREE subgroups:
- Localised to the skin, eye and mouth
- Local central nervous system disease (encephalitis alone)
- Disseminated infection with multiple organ involvement
- Risk is greatest when the woman acquires a new infection (primary genital herpes) particularly within 6 weeks of delivery
What is the general management of herpes?
- Swab to diagnose HSV
- If herpes suspected, refer to a genitourinary physician to confirm the diagnosis by viral culture and PCR
- Aciclovir (400 mg tds) is recommended
- For women presenting within 6 weeks of expected delivery, type-specific HSV antibody testing is advisable
What is the management of primary infections of herpes in pregnancy?
- If the infection occurs before the 6 weeks prior to expected delivery, the pregnancy should be managed expectantly and vaginal delivery anticipated
- C-section for ALL women developing first-episode genital herpes in the 3rd trimester (particularly if within 6 weeks of delivery)
- If the woman chooses vaginal delivery, rupture of membranes and invasive procedures should be avoided
- IV aciclovir should be given intrapartum to the mother
What is the management of recurrent episodes of herpes?
- Aciclovir 400 mg tds considered from 36 weeks gestation
- Recurrent episodes occurring during pregnancy is NOT an indication for delivery by C-section
- Invasive procedures during labour should be avoided if there are genital lesions
What is Group B Streptococcus?
When does transmission occur?
- Streptococcus agalactiae is a Gram-positive coccus
- It is a vaginal commensal that can cause sepsis in the neonate
- Transmission occurs between the time of rupture of membranes to delivery
- It is the most common cause of severe early-onset (within 7 days of delivery) infection in newborns
- 21% of women carry GBS as a commensal
- Routine screening is NOT carried out in the UK
What are the clinical features of Group B Streptococcus?
- The mother does NOT experience symptoms because GBS is a commensal
- Sepsis in the neonate
- Collapse
- Tachypnoea
- Nasal flaring
- Poor tone
- Jaundice
What is the management of Group B Streptococcus?
- Antenatal
- If detected incidentally, antenatal treatment is NOT recommended because it does not reduce the likelihood of GBS colonisation at the time of delivery
- Intrapartum antibiotic prophylaxis
- Infection of the neonate occurs during labour
- Antibiotics (penicillin or clindamycin) given in labour are 60-80% effective in reducing early-onset neonatal GBS infection
- IV penicillin 3 g should be given as soon as possible after the onset of labour and 1.5 g four-hourly until delivery
- Clindamycin 900 mg should be given IV 8 hourly if allergic to penicillin
- Women undergoing an elective C-section in the absence of labour or membrane rupture do NOT need antibiotic prophylaxis
What are risk factors requiring GBS prophylaxis?
- Intrapartum fever
- Prolonged rupture of membranes greater than 18 hours
- Prematurity less than 37 weeks
- Previous infant with GBS
- Incidental detection of GBS in current pregnancy
- GBS bacteriuria
How does GBS affect the Neonate?
- Symptoms occur at or soon after birth
- Neonatal sepsis can rapidly kill
- Blood cultures should be obtained before antibiotics are commenced
- Antibiotics should be given based on trust guidelines
What is Chlamydia caused by?
Is there screening?
When does transmission occur and what are complications of chlamydia in the infant?
- Caused by Chlamydia trachomatis which is an obligate intracellular organism
- NOT routinely screened
- Women under the age of 25 booking for antenatal care should be informed about the National Screening Programme
- Transmission occurs at the time of delivery
- Transmission can cause conjunctivitis and pneumonia in the infant
What are the clinical features of chlamydia in pregnancy?
What are the pregnancy risks?
- Often asymptomatic in pregnancy
- Risks
- Preterm rupture of membranes
- Preterm delivery
- LBW
What is the management of chlamydia?
- Azithromycin or erythromycin
- NOTE: tetracyclines should be avoided in pregnancy
What is gonorrhoea caused by?
How does infection present?
- Caused by Neisseria gonorrhoeae which is a Gram-negative diplococcus
- Infection is often asymptomatic or may present with mucopurulent discharge or dysuria
- Transmission occurs at the time of delivery and can cause ophthalmia neonatorum
What are the risks of gonorrhoea?
- Preterm rupture of membranes
- Preterm birth
What is the management of gonorrhoea?
- Bacteriological swabs should be taken
- Cephalosporins are effective against gonococcus
- Empirical treatment for chlamydia should also be considered
- Contact tracing should be arranged via a GUM clinic
When does HIV transmission occur?
- Vertical transmission mainly occurs in the late third trimester, during labour, delivery or breast feeding
- Part of routine antenatal screening
What are clinical features of HIV?
- Begins with an asymptomatic stage
- Followed by gradual compromise of immune function leading to AIDS
- The interval from HIV to AIDS can be very long
What is the management of HIV in the mother?
- The risk of vertical transmission is affected by maternal viral load, obstetric factors and infant feeding
- Reducing the risk of vertical transmission
- Antiretroviral therapy (antenatally and intrapartum in the mother, for the first 4-6 weeks of life for the baby)
- Delivery by elective C-section in the presence of high viral load
- Avoid breastfeeding
- Planned vaginal delivery is possible if mother’s viral load < 50 copies/mL at 36 weeks gestation
- C-section recommended in women with hepatitis C coinfection
- Women with a high viral load should receive IV azidothymidine (AZT) if they are undergoing a planned C-section or present with spontaneous rupture of membranes
What is the management of HIV in the infant?
- Cord clamped ASAP and the baby bathed immediately after birth
- Advised not to breastfeed baby
- All infants given azidothymidine for 4-6 weeks after birth
- Neonates test positive for HIV antibodies because of passive transfer from the mother
- HIV diagnosis in the neonate requires PCR (normally carries out at birth, 3 weeks, 6 weeks and 6 months)
What Hepatitis B and how is it mainly transmitted?
Is it part of the routine screening?
How can transmission be prevented?
- DNA virus that is mainly transmitted in the blood, but also saliva, semen and vaginal fluid
- It is part of the routine screening for pregnant women
- High rate of vertical transmission in women who are positive for HBeAg
- Transmission is 95% preventable through administration of the vaccine and immunoglobulin at birth
What are the clinical features of Hepatitis B?
- Many people have no symptoms
- The incubation period can be 6 weeks to 6 months
How and when can HepB vertical transmission be reduced?
- Hepatitis B immunoglobulin and the vaccine help reduce vertical transmission
- The immunoglobulin should be given immediately after delivery
- The vaccine is given at birth, 1 month and 6 months
In what conditions is the risk of HepC transmission increased?
Is HepC included in routine screening?
- Risk of transmission is higher in HIV co-infection
- NOT part of routine screening
What are the clinical features of Hepatitis C?
- Can lead to cirrhosis and hepatocellular carcinoma
- 80% are asymptomatic
What is the management of Hepatitis C?
- Detect anti-HCV antibodies
- Confirm with PCR for the virus
- In non-pregnant adults, administer interferon and ribavirin (CONTRAINDICATED in pregnancy)
What are the three stages of labour?
- 1st STAGE: begins with the onset of contractions and ends when full cervical dilatation has been reached
- 2nd STAGE: begins with full cervical dilatation and ends with the birth of the baby
- 3rd STAGE: begins with the birth of the baby and ends with complete delivery of the placenta and membranes
What are the 3Ps of Labour?
- Powers
- Passage
- Passenger
- If any of these three are abnormal, it is likely to result in an abnormal delivery
What are the boundaries of the pelvic inlet?
Read Netters Flashcards
- Anteriorly - upper border of the symphysis pubis
- Laterally - upper margin of the pubic bone, ileopectineal lien and the ala of the sacrum
- Posteriorly - promontory of the sacrum
What are the normal diameters of the pelvic inlet? (Read Netters Flashcards)
- Transverse = 13.5 cm
- Anterior-posterior = 11.0 cm
- The foetal head usually enters the pelvis orientated in the transverse position
What is the angle of the pelvic inlet?
- The angle of the inlet is normally 60 degrees to the horizontal
- NOTE: this can be higher in Afro-Caribbean women
What is the midpelvis?
- Described as the area bounded anteriorly by the middle of the symphysis pubis , laterally by the pubic bones, the obturator fascia and the inner aspect of the ischial bone and spines, and posteriorly by the junction of the second and third sections of the sacrum
- The midpelvis is almost round (similar transverse and anterior-posterior diameter of around 12 cm)
Why are the ischial spines of the midpelvis palpable vaginally?
- To assess descent of the presenting part on vaginal examination
- Station zero is at the level of the ischial spines
- Instrumental delivery is only possible if the foetal head has reached the level of the ischial spines or below
- To provide a local anaesthetic pudendal nerve block (this may be used for a vacuum or forceps delivery)
What are the boundaries of the pelvic outlet?
- Anteriorly - lower margin of the symphysis pubis
- Laterally - descending ramus of the pubic bone, ischial tuberosity and the sacrotuberous ligament
- Posteriorly - last piece of the sacrum
What are the diameters of the pelvic outlet?
- Anterior-posterior = 13.5 cm
- Transverse = 11 cm
- IMPORTANT: this means that at the inlet, the transverse diameter is widest, then at the outlet, the AP diameter is widest. This means that the foetal head must rotate from a transverse to AP position as it passes through the pelvis
- This usually happens at the midpelvis where the dimensions are roughly equal
How does the pelvic shape change at the end of the third trimester?
- Pelvic ligaments loosen towards the end of the third trimester, the pelvis becomes more flexible and the diameters may increase during labour
- The pelvic dimensions can also be enhanced by changing the maternal position during labour
What are some of the different pelvic shapes?
- The gynaecoid pelvis is the most favourable for labour and is also the MOST COMMON
- The android-type pelvis predisposes to failure of rotation and deep transverse arrest
- The anthropoid pelvis encourages an occipito-posterior position
- A platypelloid pelvis is also associated with an increased risk of obstructed labour due to failure of the head to engage, rotate or descend
What is the pelvic floor and how does it affect the foetal head? (Read Netters Flashcards)
- Formed by the two levator ani muscles which form a musculofascial gutter during the 2nd stage of labour
- This encourages the foetal head to flex and rotate as it descends from the midpelvis to the pelvic outlet
What is the perineum?
- This is the final obstacle
- The perineal body is a mass of fibrous and muscular tissue lying between the vagina and the anus
- This is relatively resistant in the nulliparous woman
- Vaginal birth may result in tearing or an episiotomy
- The perineum is more stretchy in multiparous women, resulting in faster labour
What is the foetal skull made out of?
- Vault
- Face
- Base
How are the sutures described in a foetus?
- At the time of labour the sutures of the vault are soft, unossified membranes
- The sutures of the face and skull base are firmly united
- The sutures allow the bones to move and overlap
What is the vault composed of?
- The vault is composed of the parietal bones and parts of the occipital, frontal and temporal bones
What are between the bones of the vault?
4 membranous structures
- Sagittal
- Frontal
- Coronal
- Lambdoidal
What are fontanelles?
- Fontanelles are the junctions of the sutures
Where is the anterior fontanelle?
- The anterior fontanelle (aka bregma) is at the junction of the sagittal, frontal and coronal sutures
Where is the posterior fontanelle?
- The posterior fontanelle lies at the junction of the sagittal suture and the lambdoidal suture (this is smaller and triangular)
Why are foetal bones in the skull compressible?
- Allows moulding to occur as the head passes through the pelvis
What may severe moulding or moulding early in labour be due to?
- Obstructed labour
- Foetal malposition (failure of the head to rotate)
- Cephalopelvic disproportion (mismatch between the size of the foetal head and maternal pelvis)
What is the vertex?
- The vertex is the area bounded by the two parietal bones and the anterior and posterior fontanelles
- In normal labour, this is the presenting part
What is the posterior fontanelle used to define?
- The position of the foetal head in relation to the pubic symphysis
- By feeling the position of the anterior and posterior fontanelles on vaginal examination, the foetal head position during labour can be ascertained
Which position is most favourable for spontaneous vaginal birth?
- Occipito-anterior (OA) position
Which position is a malposition that may result in prolonged labour, instrumental delivery or C-section?
- Occipito-transverse (OT) position
What is the shape of the foetus’ head?
- Ovoid
What does the attitude of the foetal head mean?
- The attitude of the foetal head refers to the degree of flexion and extension of the upper cervical spine
- Different longitudinal diameters are presented to the pelvis depending on the attitude of the femoral head
- With further extension of the head, the occipito-frontal diameter presents
What is the greatest longitudinal diameter which a foetus may present with?
- The mento-vertical and is around 13 cm
- This is known as brow presentation and is usually too large to pass through the normal pelvis
What is a face presentation?
- The submento-bregmatic diameter is from below the chin to the anterior fontanelle (roughly 9.5 cm)
- This is called face presentation
- This can deliver vaginally when the chin is anterior (mento-anterior position)
Describe the general physiology of labour
- The trigger that initiates human labour is poorly understood
- The cervix, which is initially long, firm and closed with a protective mucus plug must soften, shorten, thin out (effacement) and dilate for labour to progress
- The uterus must change from a state of relaxation to an active state of regular, strong, frequent contractions to facilitate transit of the foetus through the birth canal
What happens to the Uterus during labour?
- Prostaglandins and oxytocin increase intracellular calcium ions, thereby stimulating contraction
- Beta-adrenergic compounds and CCBs do the opposite
- Unique to the uterus, the actin-myosin interaction occurs along the full length of the filaments so that there is a degree of shortening with each successive interaction
- This progressive shortening is called retraction and occurs in the upper part of the uterus
- This results in the development of the thicker, actively contracting ‘upper segment’
- Meanwhile, the lower segment of the uterus becomes thinner and more stretched
- This will eventually result in the cervix being taken up (effacement) into the lower segment of the uterus thereby forming a continuum for the passage of the foetus
- There are gap junctions between myometrial cells in the uterus which facilitates the passage of various products of metabolism and electrical current between cells
- These gap junctions are absent during pregnancy but appear in abundance at term
- The increase in the number of gap junctions allows greater coordination of myocyte activity
- Prostaglandins stimulate the formation of gap junctions
- Uterine contractions are involuntary
- Frequency of contractions varies during labour and with parity
- Through most of labour, they occur at intervals of 2-4 minutes
- This is described in terms of frequency within a 10-minute period (e.g. 2 in 10)
- The duration of contractions varies from 30-60 seconds
- The frequency of contractions can be recorded using a CTG
- The amplitude of intrauterine pressure generated with each contraction ranges from 30-60 mm Hg
What happens to the Cervix during labour?
- Contains myocytes and fibroblasts separated by ECM
- Interactions between ECM components keeps the cervix closed early in pregnancy
- Under the influence of hormonal mediators (e.g. prostaglandins), there is an increase in proteolytic activity and a reduction in collagen and elastin
- Interleukins cause pro-inflammatory changes with significant invasion of neutrophils
- Dermatan sulphate is replaced by hyaluronic acid (more hydrophilic) resulting in an increase in water content of the cervix
- This leads to cervical softening/ripening so that when contractions begin, they can bring about effacement and dilatation
How does progesterone maintain uterine relaxation?
- Suppresses prostaglandin production
- Inhibits communication between myometrial cells
- Prevents oxytocin release
What does oestrogen do prior to labour?
- Oestrogen opposes the action of progesterone
- Prior to labour, there is a decrease in progesterone receptors and an increase in oestrogen concentration relative to progesterone
- Prostaglandin synthesis by the chorion and decidua is enhanced, leading to an increase in calcium in the myometrial cells
- The changes in hormones also increases gap junction formation
Where is CRH produced and what is its action before labour?
- In the placenta
- Potentiates prostaglandins and oxytocin for myometrial contractility