Obstetrics and Gynaecology - Passtest Flashcards

1
Q

What would you do if a mother was exposed to a child with slapped cheek syndrome/parvovirus 19 infection?

A

Urgent referral to foetal medicine unit (to be seen within 4 weeks) and do serial USS as well as doppler to investigate for foetal anaemia, heart failure, and hydrops. USS can occur within 4 weeks after the onset of symptoms or estimated time of seroconversion.

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2
Q

When is risk of transmission of parvovirus 19 highest?

A

Less than 20 weeks

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3
Q

How can you confirm if the foetus has been exposed to parvovirus 19?

A

By sampling amniotic fluid and looking for parvovirus DNA

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4
Q

If parvovirus 19 is detected in the foetus what would you do?

A

Foetal blood sampling to look for anaemia and offer intrauterine transfusions in specialist centres if anaemia is detected.

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5
Q

How would you perform an episiotomy?

A

After injecting LA, you would make a cut posterior to vagina, by holding the presenting part of the baby away. Initially, you would start the incision medially at 6 o’clock position, then mediolaterally into soft tissues of perineum and perineal skin towards the ischial tuberosity.

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6
Q

Describe chance of live birth after 1,2 and 3 miscarriages

A

1 miscarriage - 85%
2 miscarriages - 75%
3 miscarriages - 60%

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7
Q

What is a threatened miscarriage?

A

Vaginal bleeding and an ongoing pregnancy - closed os

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8
Q

What is an inevitable miscarriage?

A

Cervix begins to dilate, alongside bleeding

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9
Q

What is a missed miscarriage?

A

The foetus dies in utero but it is not expelled and often found incidentally on USS at a later date. USS shows a foetus that is smaller compared to the appearance a foetus of this gestation would have.

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10
Q

What is a complete miscarriage?

A

All products of conception are expelled from the uterus

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11
Q

What is an incomplete miscarriage?

A

Passage of some, but not all products of conception

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12
Q

What is Mittelschmerz?

A

Mittelschmerz is one-sided, lower abdominal pain associated with ovulation. German for “middle pain,” Mittelschmerz occurs midway through a menstrual cycle — about 14 days before the next menstrual period. The membrane around ovary stretches to release the egg, sometimes releasing some pressure and pain. NOTE: Fluid in pouch of Douglas is indicative or recent ovulation.

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13
Q

Describe the levels of FSH, LH and Testosterone in PCOS

A

FSH normal, LH high (ratio of FSH:LH inverted, LH>FSH in PCOS), Testosterone normal or high.

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14
Q

What is the most common type of urinary incontinence in women?

A

Stress incontinence

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15
Q

What does the WHO recommend regarding feeding of LBW infants?

A

The WHO recommends that all babies <2500g should be exclusively breastfed for the first 6 months of life as soon as they are born, seen by paediatrician and deemed clinically stable to start feeding. If mother’s breastmilk not available, try use donor human milk or formula feeding.

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16
Q

What volume of amniotic fluid is consistent with a diagnosis of polyhydramnios?

A

> 2-3L of amniotic fluid, amniotic fluid index >95 centile

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17
Q

In which part of the Fallopian tube do most ectopic pregnancies occur?

A

Ampulla

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18
Q

In which part of the Fallopian tube are ectopic pregnancies more likely to rupture and why?

A

Isthmus, as it is a narrower and more rigid part of the Fallopian tube, so ectopic pregnancies rupture here earlier than in other parts e.g. ampulla.

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19
Q

What is unprovoked vulvodynia?

A

Chronic vulvovaginal pain lasting for at least 3 months, with no underlying identifiable cause. The pain can be localised or generalised and cannot be provoked by light touch on examination. It is associated with a varying degree of dyspareunia.

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20
Q

When are women that have received treatment in colposcopy seen again?

A

Repeat smear 6 months after treatment to assess for any residual disease. If this is negative for HR HPV, she will be recalled for a smear in 3 years irrespective of age group. If it remains negative at 3 years she can have a smear at the timeframe indicated for her age group. On the contrary, if positive for HR HPV, irrespective of cytological change, she is re-referred back to colposcopy. Similarly, if there is evidence of moderate/severe dyskaryosis the woman is re-referred to colposcopy, without the need for HPV reflex testing.

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21
Q

At what gestation does the uterus distend up to the umbilicus?

A

20 weeks

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22
Q

When do pregnant women with diabetes receive retinal screening?

A

They receive retinal screening at booking, unless they have had a normal exam within 3 months. If initial screening is normal, they receive a second screening at 28 weeks. If initial screening is abnormal, receive second retinal screening test between 16-20 weeks gestation.

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23
Q

What are the likely histological features found in the ovary when there is metastasis from the GI tract?

A

About 5% of all malignant ovarian tumours are secondary, most commonly from the GI tract. Gastric tumours that metastasise to the ovary are known as Krukenberg tumours, and these contain signet ring cells.

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24
Q

What type of anaemia occurs in pregnancy?

A

Dilutional anaemia due to increase in plasma volume.

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25
Q

What are the ovarian cysts called that are found in a patient with endometriosis?

A

Chocolate cysts

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26
Q

If a woman is experiencing very severe hyperemesis gravidarum before the first scan is performed would you perform a scan if presenting at the EPAU?

A

Yes, do a scan earlier

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27
Q

Describe the rates of cervical dilatation in cm in a nulliparous and multiparous woman

A

1cm/hr in nulliparous

1.5-2cm/hr in multiparous

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28
Q

Which autoimmune condition is a recognised cause of premature ovarian failure?

A

Addison’s - autoantibodies cross react with theca interna/graulosa layers of the ovarian follicles

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29
Q

Following a large PPH, a woman develops severe headache and visual field defect. What is this complication called?

A

Sheehan’s syndrome

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30
Q

What does a routine antenatal examination involve?

A

If after 24 weeks: symphysis-fundal height, alongside urine dipstick and blood pressure. Abdominal palpation for foetal presentation should be done after 36 weeks as before that it is not reliable. Foetal heart rate monitoring with doppler is not indicated and done for reassurance.

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31
Q

In which phase of the menstrual cycle does premenstrual syndrome (PMS) occur?

A

In the luteal phase

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32
Q

What is stress incontinence?

A

Characterised by a small volume loss of urine occurring with increases in intra-abdominal pressure e.g. during coughing/laughing/sneezing. Caused by bladder outflow tract and pelvic floor weakness. Usually requires surgical correction.

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33
Q

What is urge incontinence?

A

Detrusor muscle instability which may be associated with local urogenital disease - e.g. cystitis, urethritis or tumours or neurological conditions - e.g. dementia, CVA, spinal cord compression

34
Q

What is overflow incontinence?

A

Associated with mechanical pressures on the bladder outflow tract causing urinary retention with associated secondary overflow e.g. obstruction - prostatic enlargement, urethral stricture, tumours, or neuropathic bladder - diabetes, MS, spinal cord compression

35
Q

What is functional incontinence?

A

The inability in reaching a toilet due to physical or cognitive impairment e.g. confusional states, arthritis, depression

36
Q

What is the first-line investigation for endometriosis?

A

TVUSS

37
Q

What is the gold-standard diagnostic investigation for endometriosis?

A

Laparoscopy

38
Q

Describe the cellular architecture of the endometrium

A

Tubular glands in a pseudostratified columnar appearance = Simple columnar cells

39
Q

Treatment for trichomonas vaginalis

A

Metronidazole 400-500mg twice daily (BD) for 5-7 days

40
Q

Treatment for gonorrhoea

A

Ceftriaxone 500mg IM and 1g PO azithromycin

41
Q

What % of complete molar pregnancies go on to be invasive?

A

15%

42
Q

What is the best way to check for ovulation?

A

Test progesterone 7 days before period i.e. day 21 progesterone if 28 day cycle

43
Q

What is the best way to check for trichomonas infection?

A

Wet mount and high vaginal swab

44
Q

Which organs does GTD metastasise to?

A

Pulmonary metastasis and thyroid dysfunction

45
Q

What is the most common type of ovarian cancer?

A

Serous adenocarcinoma - a type of epithelial tumour

46
Q

What level of Hb in the postpartum period is considered to be anaemia?

A

<100g/L in postpartum period is classified as anaemia according to the WHO. It is managed with oral iron supplementation for 3 months

47
Q

List the contributing factors for second trimester miscarriages

A

Septate/bicornuate uterus (due to incomplete fusion of paramesonephric ducts), cervical incompetence, SLE, APS

48
Q

When does ovulation occur in relation to the LH surge?

A

LH surge triggers ovulation approximately 12 hours its peak. FSH also surges at same time as LH but has a smaller peak so LH surge more reliable marker of ovulation

49
Q

15 year old presents to GP never having a period. Normal external female genitalia, but vagina ends as a blind pouch. No uterus or o varies are palpable. What is the most likely diagnosis and karyotype?

A

46XY - Androgen Insensitivity Syndrome - complete resistance of testosterone produced by male gonads in utero. Wolffian duct structures do not develop as they need testosterone. Since patient is XY, Müllerian inhibitory factor (MIF) will cause regression of Müllerian duct structures so patient will have neither male nor female internal genitalia.

50
Q

What is the treatment for PID?

A

1g ceftriaxone IM (one dose), metronidazole 400mg BD and doxycycline 100mg BD for 14 days

51
Q

Describe the initial investigations for hyperprolactinaemia

A

Exclusion of hypothyroidism, chronic renal failure and pregnancy as a cause

52
Q

What HRT regimen would you recommend to a woman that has irregular periods and vasomotor symptoms?

A

Oestradiol OD for a 3 month period, with norethisterone on the last 14 days of the 3 month period. If she had regular periods would give norethisterone on the last 14 days of the cycle.

53
Q

Treatment for lichen sclerosus following steroids

A

Topical tacrolimus

54
Q

What is the most common site for referred ovarian pain?

A

Periumbilical region - the ovaries receive sympathetic innervation from the ovarian plexus and parasympathetic innervation from the uterine (pelvic) plexus. The nerve supply runs along the suspensory ligament of the ovary, close to the blood vessels

55
Q

Which lymph nodes do ovarian cancers and endometrial cancers (adenocarcinoma) often metastasise to?

A

Para-aortic lymph nodes

56
Q

Which lymph nodes do cervical cancers (squamous) often metastasise to?

A

Pelvic lymph nodes along the iliac arteries

57
Q

Which is the most accurate blood test for checking for menopause?

A

A rise in FSH. At the menopause follicles disappear and are replaced with fibrous tissue. The decreased production of oestrogen from the ovaries results in a loss of negative feedback on the pituitary and a rise in FSH.

58
Q

What is foetal hydantoin syndrome?

A

Constellation of symptoms and signs caused by a woman taking phenytoin during pregnancy: IUGR, microcephaly, cleft lip/palate, mental retardation, hypo plastic fingernails, distal limb deformities and developmental delay.

59
Q

What is primary PPH?

A

Bleeding within 24 hours after delivery

60
Q

What is secondary PPH?

A

Bleeding after 24 hours after delivery until 6 weeks postpartum

61
Q

What are the investigations for anti-phospholipid syndrome?

A

Lupus anticoagulant ± anticardiolipin antibody

62
Q

What are the signs of APS?

A

Recurrent or atypical venous thromboses, arterial thromboses, recurrent miscarriage/late foetal loss, pre-eclampsia/foetal growth restriction, thrombocytopaenia.

63
Q

How would you manage a patient with a new diagnosis of APS?

A

Acutely: anticoagulate with heparin then warfarin. After recovery: consider life-long anticoagulation, assess for SLE. Following pregnancy: low dose aspirin and LMWH from first positive pregnancy test until delivery.

64
Q

What is the cut-off period for giving birth in a woman with gestational diabetes?

A

40+6

65
Q

What prophylactic measures are taken for all women having a TAH?

A

IV co-amoxiclav (broad spectrum ABs) intraoperatively

66
Q

What is premenstrual dysphoric disorder?

A

A severe form of PMS. Consider giving SSRI e.g. fluoxetine

67
Q

Describe the Hb cut-offs for anaemia in the first and second trimesters.

A

First trimester 110g/dL (up to 12 weeks) and <105g/dL in second trimester - as this is when the most volume expansion occurs.

68
Q

What is the first-line management of PMS?

A

COCP and lifestyle changes - check

69
Q

After stopping diabetes meds following delivery in a woman with GDM, when should she have her blood glucose checked again?

A

A fasting plasma glucose test should be conducted by the GP at 6-13 weeks postpartum to check for persistent hyperglycaemia

70
Q

Treatment of hirsutism and acne in a woman with PCOS

A

Dianette - co-cyprindiol
Contains anti-androgen
Not used in those without hirsutism/acne as increased risk of VTE compared to other COCPs

71
Q

Which is the first diagnostic investigation that can be conducted for Down’s syndrome?

A

Chorionic villus sampling (CVS) can be conducted from 11 weeks onwards for karyotyping. Risk of miscarriage is 0.7% in 14 days and 1.3% in 30 days. Amniocentesis can be conducted from 15 weeks onwards if high risk for Down’s syndrome. Miscarriage risk is 0.6%.

72
Q

What does the quadruple test involve?

A

Screening test between 15-20 weeks of pregnancy. Includes AFP, bHCG, inhibin A, unconjugated oestriol.

73
Q

What does the combined test involve?

A

Screening test that includes bHCG, PAPP-A (pregnancy associated plasma protein A), and nuchal translucency test. First two are detected in blood and the last is measured on USS.

74
Q

Which contraceptive would you prescribe with someone on enzyme inducers e.g. carbamazepine with uterine distortion due to fibroids?

A

Progesterone-only injectable

75
Q

What is ovarian stromal hyperthecosis?

A

Hyperplasia of the ovarian stroma and clusters of luteinising cells distributed throughout the ovarian stroma. Leads to increased androstenedione and testosterone leading to subsequent hirsutism and virilism.

76
Q

How often should pregnant women with diabetes be seen?

A

Every one to two weeks in the joint diabetes and antenatal clinic throughout their pregnancy.

77
Q

What hormone profile would you see in hypogonadotrophic hypogonadism e.g. Kallman syndrome

A

Low GnRH, LH, FSH and oestrogen

78
Q

What hormone profile would you see in primary hypogonadism e.g. Turner’s syndrome (45 XO), Klinefelter’s (47 XXY)

A

High GnRH, LH, FSH, low oestrogen

79
Q

Which part of the brain is most commonly affected in Sheehan’s syndrome?

A

Anterior pituitary (absent prolactin)

80
Q

How would you check a patient’s ovarian reserve?

A

Anti-Mullerian hormone