Obstetrics Flashcards
When is the embryo most sensitive to teratogens
embroyonic period in first trimester
When does fetus get in head down position?
weeks 32-35
What are breast changes in pregnancy
mastodynia, breast engorgement, colostrum secretion
Naegel’s rule
EDD= first LNMP + 1 year - 3 M + 7 days
Pelvic organ changes in pregnancy
Chadwick’s sign, Hegar sign, Goodell sign, Ballottement, leucorrhea, pelvic ligament relaxation, abdominal enlargement, uterine contractions
Diagnosis of pregnancy
Fetal heart tones, uterine size/fetal palpation, sonography, serum or urine pregnancy test
Best time to estimate gestational age via ultrasound
13-20 weeks is most accurate parameter
Fundal height used to measure
uterine size
Gold standard for diagnosis of early pregnancy failure
cardiac activity absence on ultrasound. lab findings also show lack of increase of serial B hCG levels
complications of pregnancy failure
DIC
aminopterin effect on child while pregnant
blocks folic acid= neural tube defects causing cleft lip and cleft palate
anti epileptics effect on child while pregnant (phenytoin, valproic acid)
CV abnormalities, cleft palate, microcephaly
effect of isotretinoin in pregnancy
neural tube defects, cleft palate, heart defects, abnormalities of outer ears, micronathia
anti-anxiety meds (lithium, phenothiazine, diazepam) in pregnancy
cleft lip/palate
androgens and progestins effect in pregnancy
female fetuses more masculine, clitoris larger than normal, fused labia, scrotum, and penis
DES effect in pregnancy
abrnormalities of uterus, vagina, and cervix
SSRI effect in pregnancy
irritability, tremor, increased RR, nasal congestion, diarrhea
invasive genetic diagnostic testing
chorionic villus sampling done in first trimester and amniocentesis, done after 15 week
Quad marker screen done between 15-20 weeks pregnancy to detect the following:
alpha fetoprotein, hCG, unconjugated estriol, and inhibin-A
Which hormones are produced by placenta, seen 15-20 weeks of pregnancy?
hCG and Inhibin-A
Unconjugated estriol
protein produced by placenta and baby’s liver
prognosis of edwards and patau syndrome
edwards- usually die in fetal stage. Patau- usually die within days
trisomy 13
patau syndrome
trisomy 18
edwards syndrome
which vaccines are contraindicated in pregnancy
HPV, influenza in live attenuated form, MMR, varicella
standard visits when pregnant
every month at 0-32 weeks, 32-36 every 2 weeks, after 36 weeks every week visit
types of gestational trophoblastic diseases
hydatidiform mole and gestational trophoblastic neoplasia
types of gestational trophoblastic neoplasia
persistent/invasive mole, choriocarcinoma, and placental-site trophoblastic tumor
Most common form of GTD
hydatidiform mole
GTD characterized by
beta subunit of hCG
Patient presents with abnormal uterine bleeding at 8 weeks gestation, has excessive amounts of N/V, larger uterus than expected, and enlarged cystic ovaries that are palpable. She has not had any previous pregnancies, Diet deficient in folic acid, poor, and is 18 years old. Dx and tests?
Hydatidiform mole. Serum hCG beta subunit greater than 40,000 mU/mL and urinary hCG greater than 100,000 units/24 hours. Imaging- US and CXR to r/o pulmonary metastases of trophoblast