Obstetric Anesthesia: Hertz cont. Flashcards
How is chronic HTN defined?
What drug is safe for mom to treat it?
BP > 140/90 before 20 weeks gestation
Labetolol (mixed alpha, beta blocker)
What is the triad of symptoms of preeclampsia?
HTN >140/90 or > 20% of baseline
Proteinuria > 300mg /24 hrs AND/OR
Edema (hand, face)
What are the risk factors of preeclampsia? (5)
Primarily primigravidas
Primipaternity
Previous Hx
Obesity
Multiple gestations
What is the etiology of preeclampsia? (4)
- Not definitely known
- Abnormal fetal trophoblastic cell migration through placenta resulting in increased BP
- Changes in placental/abnormal vascular endothelium
- Platelet adhesion occurs resulting in release of seratonin, thromboxane
What vasoconstrictors are more prevalent in preeclampsia? (4)
- Thromboxane (AT1, AT2 platelet aggregation)
- Endothelin (causes pulmonary HTN)
- Angiotensin II
- Serotonin
How is severe preeclampsia defined?
One of the following:
- BP > 160/110
- Proteinuria > 5 Grams/24 hrs
- Symptoms such as headache, blurred vision, oliguria, pulmonary edema, myocardial dysfunction, RUQ pain (liver congestion), platelets < 100k, HELLP
Severe preeclampsia contributes to ___ - ___% of maternal deaths and ____% perinatal deaths.
20-40
20
What turns preeclampsia into severe eclampsia?
HELLP
What is contraindicated in HELLP syndrome?
REGIONAL
Can seizures occur with preeclampsia?
Yes
What is the treatment of preeclampsia?(5)
- Bedrest
- Sedation
- Labetalol, Hydralazine
- Magnesium sulfate
- Delivery
What are antihypertensives safe for mom? (5)
- Labetolol 5-10 mg IV
- Hydralazine 5mg IV
- Methyldopa 250-500 mg PO (alpha 2 agonist)
- Magnesium sulfate
- Nitroprusside (arterioles, venules)
What are attributes of magnesium sulfate? (3)
Treats hyperreflexia and prevents seizures
Direct vasodilating action on smooth muscle of arterioles and uterus
Potentiates sedation
Excessive magnesium sulfate can cause what? (6)
- prolonged PR interval, widened QRS (5-10 mEq)
- muscle weakness (10 mEq)
- loss of DTRs
- respiratory depression
- SA, AV block (15 mEq)
- cardiac arrest (25 mEq)
SNP in doses > _____mcg/kg/min or prolonged period can increase risk of what?
10 mcg/kg/min
cyanide toxicity
What drugs do you NOT use in pregnant women?
ESMOLOL –adverse fetal effects
Calcium channel blockers–tocolytic action and potentiate circulatory depression induced by magnesium
What is the anesthetic management of severe preeclampsia?
Pts are critically ill and need to be stabilized prior to any type of anesthesia.
Need a-line
What are antihypertensives needed in OR?
Labetalol
Hydrazaline
NTG
Nitroprusside
What are signs of magnesium toxicity? (3)
Oversedation
Loss of reflexes
DROPPING SATURATIONS
How do we manage a preeclamptic patient? (3)
Monitor UO
Hypovolemia treated with no more than 500ml LR
Check platelets and coags prior to regional anesthesia
Avoid regional if platelets < _____, but lowest is _____.
100k
70k
What is ideal anethesia for preeclamptic pt?
Epidural or spinal
Vaginal
C/s