OBgyn Notes Flashcards
The CDC defines anemia in pregnancy as a hematocrit below 33% in the first and third trimesters or below 32% in the second trimester. What is the most likely recommendation in a pt with hematocrit of 33% in the first trimester?
Oral ferrous sulfate
[iron supplementation]
Uterine eccyesis
Ectopic pregnancy
_____ incontinence is failure to empty adequately due to underactive detrusor; presents with increased post-void residual (normal = 50-60 cc)
Overflow
Fetal growth restriction is a significant risk factor for subsequent development of what diseases as an adult?
Cardiovascular disease Chronic HTN Stroke COPD Type II diabetes mellitus Obesity Cognitive delay
Treatment for chorioamnionitis
Gentamicin
Clindamycin
Indomethacin is contraindicated as a tocolytic after ____ weeks due to risk of premature closure of ductus arteriosus
32 weeks
A patient presents with incomplete spontaneous abortion and products of conception can be visualized at the cervical os. What is the next best step in management?
A. Dilation and curettage B. Expectant management C. Misoprostol D. Pelvic rest E. Tissue extraction with forceps
E. Tissue extraction with forceps
Biophysical profile shows score of 8-10 — what do you do?
Nothing - this is reassuring
Preferred HAART in early prenatal care when mom is HIV positive
Tenofovir + Emtricitabine
Etiology and management of early decelerations on FHR monitoring
Fetal head compression
Do nothing - these are not worrisome
Most common ovarian neoplasm in women older than 30
Epithelial cell tumors
Features of severe preeclampsia
BP > 160/110 on 2 occasions Thrombocytopenia Impaired liver function Renal insufficiency Pulmonary edema New onset cerebral or visual disturbance
ACOG recommendations for routine cervical cancer screening
Begin at age 21
Age 21-29 = Cytology q3 years
Age 30-65 = Cytology + HPV cotesting q5 years
Stop screening after age 65 if no history of moderate/severe dysplasia or cancer, and either 3 negative paps in a row OR 2 negative co-test results in a row in the past 10 years with most recent test in the last 5 years
Tocolytic that competes with calcium for entry into cells; indicated in pts less than 32 weeks for neuroprotection
Magnesium sulfate
Methods to confirm rupture of membranes include testing ____ fluid for ferning and nitrazine testing
Vaginal fluid
[cervical fluid will give false positive ferning. Normal pH of vaginal secretions is 4.5-6.0, amniotic fluid has pH of 7.1-7.3 which will turn nitrazine paper blue. False positives occur when semen or blood is present]
Rotterdam criteria for PCOS
Chronic anovulation
Hyperandrogenism
Polycystic ovaries on ultrasound
[dx requires 2/3]
Progestin mini pills for contraception MOA:
A. Immobilize sperm B. Inhibit estrogen C. Inhibit ovulation D. Thicken cervical mucus E. Thicken endometrium
D. Thicken cervical mucus
Endometrial tumor invades less than half of the myometrium or endometrium
A. Stage Ia B. Stage Ib C. Stage II D. Stage III E. Stage IV
A. Stage Ia
Molar pregnancy leads to very high concentrations of hCG — which has an alpha subunit that is identical to those found in LH and TSH. What are the consequences of this hormone change?
Lutein ovarian cysts
Elevated T3/T4 (thus low TSH)
Treatment for group B strep if pt is allergic to PCN but it is not an anaphylactic allergy
Cefazolin
Recommended dose of folic acid in women with a previous pregnancy complicated by a fetal neural tube defect
4 mg/day
Endometrial tumor invades more than half the myometrium
A. Stage Ia B. Stage Ib C. Stage II D. Stage III E. Stage IV
B. Stage Ib
What progesterone level is suggestive of a normal pregnancy?
> 25 ng/mL
When would you NOT need to treat a patient positive for group B strep with antibiotics during delivery?
Only if patient is having C section and there was no rupture of membranes at onset of labor
Antibiotic used for GBS prophylaxis in pts with penicillin allergy who do NOT have a history of anaphylaxis
Cefazolin
When should pts with known BRCA mutations begin breast cancer screening?
Age 25
How long before pregnancy must MMR vaccine be given to be safe?
3 months prior
5 components of Bishop score
Dilation Effacement Station Consistency Position
If previous HIV status unknown and now mom is delivering with active HIV, she should be treated with ____ at the time of delivery
AZT (Zidovudine)
Define late-term pregnancy vs. post-term pregnancy
Late-term = 41 to 41+6 weeks
Post-term = 42+ weeks
In a patient with preterm labor, antibiotic therapy with ____ and ____ has been found to prolong the latency period by 5-7 days as well as reduces incidence of maternal chorioamnionitis and neonatal sepsis
Ampicillin
Erythromycin
What category of fetal heart tracing is described below?
Absent variability, fetal bradycardia, recurrent late or variable decelerations
Category 3
[GO IMMEDIATELY TO C SECTION]
Both are typically treated together, but to be specific:
Gonorrhea is treated with either _____ or _______
Chlamydia is treated with either _____or ______
Ceftriaxone; fluoroquinolone
Doxycycline; azithromycin
Medical treatment options for urge incontinence and their associated contraindications
Beta-3 agonists such as Mirabegron (myrbetriq) — contraindicated in HTN, ESRD, or liver disease
Tolterodine (Detrol) — contraindicated in narrow angle glaucoma
Patient in labor with umbilical cord prolapse but reassuring fetal heart tones. How do you manage pt?
Elevate fetal head and proceed to C section
Biophysical profile shows score of 0-2, what do you do?
Deliver!
Third trimester use of SSRIs for anxiety/depression has been associated with what fetal effects?
Neonatal agitation Abnormally increased or decreased muscle tone Tremor Temperature instability Insomnia or somnolence Difficulty feeding
Quad screen result for Downs
Beta hCG and inhibin A = elevated
Estriol and AFP = decreased
Factor V leiden mutation results in an altered factor V that is resistant to inactivation by protein C. What pregnancy complications are associated with this mutation?
Stillbirth, preeclampsia, placental abruption, and IUGR
Fetal growth restriction can be assessed with amniotic fluid volume, umbilical artery Doppler studies, and NST. What is the purpose of the umbilical artery Doppler study?
Reveals the systolic/diastolic ratio
A normal S/D ratio indicates fetal well-being. An increase in ratio reflects increased vascular resistance
Incontinence characterized by overactive detrusor
Urge incontinence
At _____ weeks gestation, the uterus is approximately at the level of the pubic symphysis
At _____ weeks gestation, the uterus is halfway between the pubic symphysis and umbilicus
At _____ weeks gestation, the fundus of the uterus is at the level of the umbilicus
12
16
20
OCPs are the primary tx for dysmenorrhea. This is because the ____ in OCPs cuases endometrial atrophy, thus there are less prostaglandins being produced
Progestin
Blueberry muffin baby, deafness, cataracts, congenital heart defects, IUGR and abortion in 1st trimester, petechiae and purpura in 3rd trimester
Congenital rubella (german measles)
Tocolytic that acts as nonspecific COX inhibitor, thus blocking prostaglandin production
Indomethacin
What is the first step in management following an abnormal MSAFP test (found on triple screen)?
Ultrasonography
This is to rule out multiple gestation or inaccurate dating
Depression in pregnancy is typically tx with SSRIs. Which SSRI is considered category D drug due to increased risk of fetal cardiac malformations and persistent pulmonary HTN, and thus should NOT be used in pregnancy?
Paroxetine
Confirm HSV 1 or 2 infection with ____ of active lesions.
Prophylaxis is tx with acyclovir from week ____ to delivery
PCR
Week 36
Use of indomethacin as a tocolytic is associated with what intrapartum complication?
Oligohydramnios
Endometrial tumor invades stromal CT but confined to uterus
A. Stage Ia B. Stage Ib C. Stage II D. Stage III E. Stage IV
C. Stage II
Define fetal growth restriction
Weight less than 10th percentile
At the time of delivery, you note retraction of the fetal head (turtle sign) indicating shoulder dystocia. What is the next best step in management?
McRoberts maneuver — hyperflex moms legs to her abdomen
[this widens the pelvis and flattens lumbar spine; note that fundal pressure and operative vaginal delivery are contraindicated in shoulder dystocia]
Tx for tertiary/neurosyphilis in pregnancy
IV PCN q4hours for 7-10 days
______ syndrome patients have male karyotype, 46XY, but female phenotype. This results from mutation or structural abnormality of the Y chromosome. All subjects are phenotypic women of normal height who fail to undergo puberty and possess normal femal external genitalia, uterus, and fallopian tubes. These patients possess gonadal streaks which require removal to prevent development of malignant transformation. They typically present with complaints of delayed puberty
Swyer syndrome
What happens if mom gets infected with syphilis in the 1st trimester?
Fetal demise —> dead and macerated fetus
What medical condition is a contraindication to use of magnesium sulfate as tocolytic?
Myasthenia gravis
T/F: small, asymptomatic subserosal fibroids do not require tx or monitoring in pregnancy
True
Fetus resumes “face-forward” position, with occiput and spine lying in the same plane
A. Engagement B. Descent C. Flexion D. Internal rotation E. Extension F. External rotation G. Expulsion
F. External rotation
CCB tocolytic that decreases intracellular free calcium concentration and induces myometrial relaxation; associated with fetal hypoxia and decreased uteroplacental blood flow
Nifedipine
What trisomy is associated with low birth weight, overlapping fingers, micrognathia, and cardiac defects?
Trisomy 18
Chronic follicular disease that affects the apocrine or sebaceous glands. It is found in the axillary, groin, perianal, perineal, and mammary areas. Initially one solitary lesion appears. After a period of time, the nodule progresses to form an abscess that yields purulent or serosanguinous drainage. Painful clusters of abscesses, sinus tracts, and sores with evidence of scarring are characteristics of chronic disease. Similar to pilonidal disease but its affinity for other intertriginous areas of the skin makes it distinctive
Hidradenitis suppurativa
Tocolytic that acts as oxytocin receptor antagonist, blocking the intracytoplasmic calcium release associated with contractions and downregulates prostaglandin synthesis
Atosiban
What 2 types of fibroids are most likely to cause issues in pregnancy?
Submucosal
Intracavitary
A pt in labor requires high-dose oxytocin therapy for induction. What electrolyte is most appropriate to replace?
Sodium
High dose oxytocin stimulates antidiuresis and natriuresis which can lead to hyponatremia. Oxytocin is structurally similar to vasopressin and at high doses can decrease urine excretion via antidiuresis independent of volume status. The resultant volume overload is sensed by the atria which release ANP, promoting natriuresis. In addition, high doses of oxytocin itself stimulates renal natriuresis.
PALM-COEIN mnemonic for AUB
Structural causes = PALM Polyp Adenomyosis Leiomyoma Malignancy (or hyperplasia)
Non-structural causes = COEIN Coagulopathy Ovulatory dysfunction Endometrial Iatrogenic/IUD Not otherwise classified
Fetal occiput rotates from its original position (usually transverse) toward the symphysis pubis (occiput anterior), or less commonly, toward the hollow of the sacrum (occiput posterior)
A. Engagement B. Descent C. Flexion D. Internal rotation E. Extension F. External rotation G. Expulsion
D. Internal rotation
What category of fetal heart tracing is described below?
Everything is normal and expected with few or absent abnormals; managed with watchful waiting
Category 1
Initial management of hydatidiform mole
Suction D and C
Chest Xray
Labs (CBC, PT/PTT, type and screen)
Rhogam if Rh negative
Serial beta-hCG (48 hours, then weekly until 0, then monthly x6months)
Advise against pregnancy x6-12 months following evacuation
What testing should be done on patient with 3 successive first trimester losses?
Lupus anticoagulant Anticardiolipin antibodies Diabetes mellitus Thyroid disease Maternal and paternal karyotypes Uterine imaging to r/o anomaly
Most common cause for a delay in the latent phase of labor
Unripe cervix
Black box warning on depo injections for contraception
May cause bone mineralization loss and long-term use is not advised
First-line treatment for uterine relaxation for retained placenta
Nitroglycerin
Biophysical profile is between 3-7 in a patient at 36+ weeks gestation, what do you do?
Deliver
Most common cause of preterm labor
Idiopathic