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ENDO > obestiy > Flashcards

obestiy Flashcards

0
Q

normal weight

A

18.5-24.9

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1
Q

underweight

A

<18.5

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2
Q

overneight

A

25-29.9

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3
Q

overweight

A

25-29.9

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4
Q

obesity 1

A

30-34.9

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5
Q

obesity 2

A

35-39.9

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6
Q

obesity III (extreme)

A

> 40

6.3% population

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7
Q

excess calories stored as

A

triglycerides in two ways–adipose cellular hyperplasia & adipose cellualr hypertrophy

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8
Q

adipose cellylar hyperplasia

A

increase in number of cells
early onset
extreme

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9
Q

adipose cellualr hypertrophy

A

increase in size only
adult onset
mild

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10
Q

weight loss leads to

A

change in adipose cell size but not number (this remains constant even with weight loss)–this is reason why weight loss is so hard and so often relapse

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11
Q

peptides and NT that increase appetite

A 
NPY
AGRP
MCH
Ghrelin*
endocannabinoids
Orexins*
Galanin
Opiods
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12
Q

peptides and nt that decrease appetite

A 
leptin*
a-MSH
CRF
CART
Neuromedian
Urocortin
CCK*
IL6
CNTF
PYY
oxyntomodulin
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13
Q

leptin is produced in

A

fat cells, gut, placenta

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14
Q

leptin

A

signals brain how much fat is stored

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15
Q

db/db and ob/ob mice

A

ob- deficient
db- defect

hyperphagia
insulin R
infertility
hyperinsulinemia

16
Q

melanin protein (MSH)

A

inhibits food intake

17
Q

agouti gene/protein

A

inhibits mSH binding to receptor–>decrease MSH–>stimulates food intake

also competes w/ MSH for Melacortin 4R

18
Q

carboxypeptide E

A

cleaves proinsulin

*fat mice lack this

19
Q

tub gene

A

retinitis, other neuro deficits–>hypothal damage–>stimulates appetite

20
Q

M4R deletion

A

hyperphagia, obesity

21
Q

M3R deletion

A

store more fat, lower lean body mass

22
Q

5HT 2C deletion

A

increase food intake, obesity, seizures

23
Q

5HT1B deletion

A

blocks anorexic effects dexfenfluramine

24
Q

Neurpeptide YKO

A

normal amounts of fat–losing gene does nto cause weight loss

25
Q

candidates for treamtnet depend on

A

degree of risk

no baritric surgery for anyone under BMI of 30

26
Q

malabsorptive surgery

A

bypass duodenum to decrease absorption

jejunoileal bypass, biliopancreatic diversion

27
Q

restrictive surgery

A

small pouch restricts volume of food intake–early satiety with normal absorption
vertical banded gastroplasty, laparoscopic adjustable gastric banding

28
Q

bombined restrive/malabsorptive

A

roux-en-y gastric bypass

29
Q

complications of restrictive/malabsorptive

A 
cholithiasis
vit B12 deficiency
incisional hernia
dumping syndrome
Fe deficient

**treat prophylactically

ENDO (5 decks)

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