Obesity

Question 1

Orlistat

Answer 1

Alli(otc) xenical. (RX)

MOA: inhibitors fat absorption via inhibition of GI lipase - decreases fat absorption

S/E
Abdominal pain
Dedication urgency and increased freq.
Steatorrhea - fatty diahrrea (White feces)

Question 2

Locaserin

Answer 2

Belviq
Act of seratonin receptors
Satiety and decreased food intake

S/E
Headache
Dizziness 
Fatigue
Not recommended with SSRI/SNRI

Inc risk malignancy

Question 3

Naltrexone/bupropion ER

Answer 3

Contrave.

MOA: naltrexone - opioid antagonist
Bupropion- inhibitor reuptake dopamine & norepinephrine

Combo leads to reduced appetite
S/E:
Nausea/vomiting
Headache
Dizziness
Insomnia

Contraindications:
Seizure disorder
Uncontrolled hypertension
Opioid use

Question 4

Phentermine/Topiramate ER

Answer 4

Qysmia

CNS receptor effects
Suppress appetite and enhance satiety

REMS and Schedule IV

S/E:
Parenthesia.
Metallic taste
Dry mouth
Dizziness

Contraindications:
Glaucoma
Hyperthyroidism

Question 5

Litaglutide

Answer 5

Saxenda.
Glp1 agonist
MOA; inhibit glucagon production- delayed gastric emptying satiety

SE
NVD dose limiting goes away with continued use
Dyspepsia
Abdominal pain/cramping
Pancreatitis

Contraindications:

Medullary thyroid cancer

Question 6

Diabetic pt?

Answer 6

Saxenda ( liraglutide)

Question 7

Sleep apnea

Answer 7

Liraglutide or phentermine/topiramate

Question 8

CV disease

Answer 8

No phenteramine

Avoid qsymia

Question 9

Cravings?

Answer 9

Contrave

Naltrexone/ bupropion

Question 10

BMI <= is 18.5

Answer 10

Under weight

Question 11

BMI >= is I8.5-25

Answer 11

Normal

Question 12

BMI >= 25-30

Answer 12

Overweight

Question 13

BMI >= 30-40

Answer 13

Obese

Question 14

BMI >= 40

Answer 14

Morbidly obese