Obesity Flashcards

1
Q

Define classification of weight based on body mass index (BMI)

A

BMI = Weight (kg) / Height (m)2

• For children/adolescents:
o Normal: <95th percentile
o Obese: ≥95th percentile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Describe recent trends in the prevalence of obesity and the public health impact of these trends

A

TRENDS:
• Decline in obesity rates among preschool children from low-income families
• >1/3 adults and almost 17% youth obese in US
o Rate for children is 3x one generation ago
• Rate of being overweight not much changed but see greater percentages of higher classes of obesity
• Prevalence does not differ between men and women
• >60 years more likely to be obese than younger adults, especially in women
• Rates vary by education and income
PUBLIC HEALTH IMPACT
• Global health problem: from increase in energy, decrease in activities, change in transportation, urbanization of countries
• Increased risk of chronic diseases
• Increased health care costs
• Loss of income from disability or premature death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Describe the development of obesity with consideration to genetic, environmental, and behavioral factors.

A

Genetic
o Obesity is a polygenic disorder (>200 genes associated)
o Genetic factors account for about 40% variance of obesity in population
o Adipose tissue accumulation, distribution, and function
Intra-uterine/ perinatal
o Maternal undernutrition in pregnancy
o Maternal smoking
o Malnutrition in infancy
o Low birth weight: higher risk for central obesity
o High birth weight: higher risk for high BMI
Environmental
o Food: access, excess, caloric density, liquid calories
o Activity
o Medications that lead to weight gain:
• Corticosteroids, oral hypoglycemics, insulin, some anti-hypertensives, tricyclic antidepressents, lithium, anti-psychotics, anti-convulsants, SSRIs
Endocrine and metabolic diseases
o Potential but rare cause of obesity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Describe metabolic complications of obesity.

A
  • Type II diabetes
  • Insulin resistance → increased risk of HT, increased fat stores, inflammatory chemicals
  • Dyslipidemia
  • Gout
  • Metabolic syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

List the criteria for the metabolic syndrome.*

A

Three or more risk factors present:
o Abdominal obesity: Waist circumference > 40 in men, >35 in females
o Triglycerides: ≥ 150 mg/dL or on meds
o HDL-C: <50 in women; or on meds
o Blood pressure: ≥ 130/≥85 mmHg or on meds
o Fasting glucose ≥ 100 mg/dL or on meds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Describe the goals of treatment for metabolic syndrome.

A
  • Lose weight to BMI <25
  • Be physically active
  • Follow heart healthy diet (DASH)
  • Quit smoking
  • Limit alcohol to moderate consumption
  • GOALS: reduce risk of heart disease by lowering LDL, HT, and managing/preventing diabetes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Outline the complications of obesity: effects on organ systems and disease development, mechanical affects on the body, surgical complications, and psychosocial consequences.

A
Respiratory
o	Obesity hypoventilation syndrome
o	Sleep apnea
CV
o	Atherosclerotic and arteriosclerotic vascular disease
o	Coronary heart disease, HT, CHF
GI
o	Gall stones
o	GERD
o	Fatty liver → steatosis →steatohepatitis →cirrhosis or hepatocarcinoma
Kidney disease
Reproductive
o	Polycystic ovary syndrome
o	Obstetric complications
Cancer
o	Endometrial, breast, colon and rectum, gall bladder, kidney, esophagus, pancreas, thyroid
Mechanical
o	Arthritis
o	Increased intra-abdominal pressure → incontinence, hernia, pseudo-tumor cerebri
Psychosocial
o	Inappropriate bias
o	Correlated with lower earnings, depression, low self-esteem
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

List approaches that physicians could take to improve the management of obesity in their practice.

A
  • Routine screening at every visit
  • Advice/strong message on benefits
  • Assess readiness to change
  • Establish goals, modest but specific
  • Recommend a plan or refer for detailed counseling
  • Follow-up at subsequent visits
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Define modest weight loss (as a % of total body weight).*

A
  • 10-15%

* Decreases BP, improves glucose and serum lipids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Discuss strategies associated with maintenance of weight loss.

A
  • 60-90 minutes of exercise daily
  • Lower dietary fat intakes
  • Lack of exceptions to diet plan
  • Social support
  • Weighing weekly
  • Alternating strategies: “watching” vs “losing” weight
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Define the level of calorie reduction recommended to produce a 1-2 pound per week weight loss.*

A

• 500-1,000 kcal/day deficit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Discuss the topics that should be included in nutrition education for weight loss.

A
•	Diet history
•	Review nutritional quality of diet
o	Energy density of foods
•	Identify sources of excess calories 
•	Establish goals for specific change
•	Create a follow-up plan
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Discuss the advantages and disadvantages of commercial weight loss programs.

A
Advantages:
o	Structure: makes plan easier to follow
o	Support and accountability 
o	Nutritionally adequate menus 
Disadvantages
o	Limited personalization of the plan
o	Cost
o	Too much structure (patients don’t learn how to make choices without program)
o	Limited research on effectiveness and long-term results
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Define the role of exercise in weight loss and maintenance.

A
  • Only modest weight loss with exercise alone
  • Most weight loss from decreased caloric intake
  • Sustained exercise is critical factor in prevention of weight regain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Identify the amount of exercise recommended for weight management.*

A

o 150 minutes weekly of moderate exercise to maintain healthy weight
o 300 minutes weekly to maximize weight loss and minimize weight regain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Discuss behavior modification techniques for weight loss.

A
Self-monitoring
o	Food intake
o	Exercise
o	Weight 
Stimulus control
o	Modify the physical/cognitive environment
o	Reduce cues for overeating/inactivity 
Substitution
o	Activity instead of eating
o	Low kcal instead of high kcal foods
Assertiveness training to express feelings and follow through with plans
Cognitive changes
o	Recognize success, not focus on failures
Social support
Goal setting (SMART goals)
Reward for achievement
17
Q

Describe the elements and benefits of a team approach to weight loss.

A
  • Doctor provides strong message
  • Dietitian provides individualized nutrition therapy
  • Exercise expert provides advice
  • Health care team provides follow-up
  • Overall: most efficient way to provide variety of expertise, better care to patient
18
Q

Define BMI levels established by the National Institutes of Health for appropriate use of bariatric surgery as part of obesity management.*

A
  • BMI >40

* BMI ≥35 and associated severe health complications and have not responded to other treatment methods

19
Q

Describe the types of surgery currently used for obesity and potential side effects of the surgeries.

A

Restrictive-malabsorptive/ Roux-en-Y: restricts food intake and decreases absorption
o Side effects:
• Dumping syndrome: rapid passage of food from pouch into small intestine, cramping, diarrhea, sympathetic discharge
• Nutritional deficiencies: protein, B12, thiamine, folate, calcium, iron, fat soluble vitamins

Restrictive: food intake is reduced
o Adjustable gastric band—low risk deficiencies, band can slip, erosions
o Gastric sleeve—remove part of stomach
o Laparoscopic Gastric Plication—sewing folds in stomach to reduce volume
o Side effects: micronutrient deficiencies

20
Q

Describe BMI levels established by the Food and Drug Administration for appropriate use of drugs as part of obesity management.*

A
  • BMI ≥30

* BMI >27 along with other risk factors (ex. HT, diabetes, dyslipidemia)

21
Q

List types and mechanism of action of obesity drugs currently approved for use in the US.

A

Phentermine
o Sympathetic amine, tolerance develops
o Short term (up to 12 weeks)

Orlistat
o	Binds lipase in gut → blocks fat absorption
o	Good if diet is high in fat
o	Approved by FDA for 1 year of use
o	OTC formulation is available (Alli)

Belviq
o Increases serotonin receptors, promotes decreases appetite and fullness

Qsymia
o Combines appetite suppressant (phentermine) and anti-seizure medication (topiramate)

Other short-term appetite suppressants: Diethylpropion, Phendimetrazine, Lorcaserin

Off-label/ not FDA approved:
o	Bupropion –depression med
o	Topiramate- seizure med
o	Zonisamide- seizure med
o	Metformin- diabetes med