OB Teratology Flashcards
The study of birth defects and their etiology
teratology
agent that acts during embryonic or fetal development to produce a permanent alteration of form or function
teratogen
Drug associated with Ebstein anomaly, a cardiac abnormality characterized by apical displacement of the tricuspid valve
Lithium
Causes phocomelia.
thalidomide
Investigators retrospectively assess prenatal exposure to particular substances between affected infants and controls.
Case-control studies
True or False. The suspected agent agent must cross the placenta.
TRUE
Studies in pregnant women have not shown an increased risk for fetal abnormalities if administered during the first (second, third, or all) trimester(s) of pregnancy, and the possibility of fetal harm appears remote.
Category A
Animal reproduction studies have been performed and have revealed no evidence of impaired fertility or harm to the fetus.
Category B
Animal studies have shown that the substance is teratogenic; no adequate and well-controlled studies in preganant women.
Category C
Substance causes fetal harm
Category D
Medication is contraindicated in pregnant women.
Category X
This substance is the most frequent nongenetic causes of mental retardation as well as the leading cause of preventable birth defects
Alcohol
This is believed to pose particularly high risk for alcohol-related birth defects and has also been linked to an increased risk for stillbirth
Binge drinking
Most common anomalies associated with anticonvulsant use (3)
Orofacial Clefts, cardiac malformations, neural tube defects
A single 150 mg dose of fluconazole to treat vulvoginal candidiasis causes fetal abnormalities. True or False
FALSE
