OB Pharmacology

Question 1

Why do we use tocolytics

Answer 1

Reduce the strength and frequency of contractions in preterm labor (22-34 weeks)

Question 2

Goals of tocolytics

Answer 2

1. Delay delivery 48 hrs for steroids
2. Provide safe transport of mom
3. Prolong pregnancy as long as safe

Question 3

NSAID/Cyclooxygenase inhibitor

Answer 3

Indomethacin

- 24-32 weeks prior to fetal surgery

Question 4

CCB

Answer 4

Nifedipine

• first line 32-34 weeks gestation
• can see transient hypotension, flushing

Question 5

Beta-2 agonist

Answer 5

Terbutaline

• 2nd line
• tachycardia, hypotension, dysrhythmias, hyperglycemia

Question 6

Antenatal steroids?

Answer 6

Used for preterm labor to accelerate fetal lung maturity (<34 weeks gestation)
- betamethasone 12 mg IM q24hrs

Question 7

Benefits of antenatal steroids

Answer 7

Lung maturity –> decreases neonatal respiratory distress syndrome, IVH, death

Question 8

Magnesium for fetal neuroprotection

Answer 8

Not indicated if >32 weeks gestation

Question 9

Magnesium for mom in pre-eclampsia

Answer 9

short term use for moms with pre-eclampsia for seizure prevention