OB/GYN Flashcards
Dysmenorrhea
- Primary Dysmenorrhea: (No Pelvic Pathology)
- E: ^Prostaglandins –> painful uterine muscle wall activity.
- Secondary Dysmenorrhea: ( Pelvic Pathology)
- E: Pelvic Pathology
- Endometriosis
- Uterine Fibroids (Leiomyoma)
- adenomyosis
- E: Pelvic Pathology
Treatment:
- Heat & Vit E
- NSAID’s (1st line)
- MOA: inhibits prostaglandin-mediated uterine activity.
- Want Contraceptives:
- 1st line for contraception and dysmenorrhea pain relief.
- combined estrogen-progestin oral pills, transdermal patch, or vaginal ring
Dysfunctional Uterine Bleeding
- Menorrhagia
- Metrorrhagia
- Oligomenorrhea
- Polymenorrhagia
-
Polymenorrhea
- Frequent cycles <21 days
-
Menorrhagia
- Heavy or Prolonged Bleeding (Normal intervals)
-
Meterorhagia
- Bleeding between expected menstrual cycles
-
Oligomenorrhea
- infrequent menstruation ( >35 days between but not >6months)
- Etiology:
- Chronic Anovulation (90%)
- Hypothalamus Pituitary Axis issues
- Extreme ages (starting or ending menopause)
- Chronic Anovulation (90%)
Dysfunctional Uterine bleeding is a result of either no ovulation or ovulation with abnormal bleeding.
- Anovulation = no progesterone because the ovum is what secretes that progesterone –> No progesterone to oppose the estrogen –> ^ risk of Endometrial cancer.
- The unopposed estrogen caused excessive endometrial growth –> outgrows its own blood supply –> dies and sluffs off at unpredictable times.
- Ovulation:
- Ovulation with increased progesterone levels dilation of endometrial vessels + Prostaglandins which results in Menorrhagia.
- Dx: Diagnosis of Exclusion
- Tx:
- Acute:
- High-dose IV estrogens titrated to stop bleeding.
- Anovulatory:
- OCP: 1st line
- reduces endometrial cancer risk by regulating unopposed estrogen.
- Progesterone only for CI to Estrogen:
- Medroxyprogesterone Acetate
- OCP: 1st line
- Ovulatory:
- OCP: Regulates Cycle
- Surgery:
- Hysterectomy: Definitive treatment
- Acute:
Vaginitis
Dia
Atrophic Vaginitis
- Pathophysiology
- Caused by a decrease in estrogen
- Patient
- Postmenopausal woman
- Presentation
- Dyspareunia, dryness, bleeding, itching
- Physical Exam
- • Show a pale, dry, shiny vaginal epithelium
-
Management
- • Lubricants, moisturizers, topical estrogen (second line)
-
SE of Vaginal Estrogens:
- PE, DVE, CVA
- endometrial cancer
- Less risk than PO estrogen
- breast Pain
Pelvic Inflammatory Disease
- complications of PID?
- What is the name of the syndrome associated with PID?
- ??
- Treatment:
- Outpatient
- Inpatient
Complications:
- Fitz-Hugh Curtis Syndrome:
- Perihepatitis with no LFT ^
- RUQ pain
- Infertility
- Ectopic
- Chronic Pelvic pain
Fibroadenoma
- What is the difference between fibroadenoma and fibrocystic breast disorder?
Fibroadenoma does not wax/Wayne with menstruation.
Fibrocystic Breast Disease
Fluctuating Estrogen
Breast Cancer
- Etiology
- Risk Factors
- Types
- Presentation:
- Physical Exam
- Diagnosis:
- Treatment:
- Prevention in High-risk Patients:
Breast Cancer
- Risk Factors
- BRAC1
- BRAC2
- Increase exposure to ESTROGEN
- Types
- Ductal Carcinoma
- METS lymphatic
- 75%
- Lobar Carcinoma
- Ductal Carcinoma
- Presentation:
- Breast Mass:
- Painless
- Hard
- Immobile
- Upper Outer Quadrant
- Unilateral Nipple Discharge
- Purulent/green/+- Bloody
- Breast Mass:
- Physical Exam
- Skin Changes:
- Pagets Disease of the Nipple:
- chronic eczematous itchy, scaling rash on the nipple/areola
- Inflammation of the Breast
- red, swollen, warm, itchy
- Peau D’ Orange –> orange peel appearance
- due to Lymphatic Obstruction
- Poor prognosis
- Diagnosis:
- Monogram:
- Microcalcification
- Spiculated
- Ultrasound:
- BEST INITIAL TEST TO EVLATUTE BREAST MASS
- Biopsy:
- Monogram:
- Treatment:
- Lumpectomy (w/ radiation) —> Mastectomy —> Regional removal of lymphnodes.
- Pharmacology:
- Based on if the tumor is Estrogen Receptor +, Progesterone Receptor +, or HER2 +
-
Anti Estorgen: (blocks estrogen receptor at breast tissue.
- Tamoxifen
-
ER + : Aromaatase Inhibitors: (< Estrogen Production)
- Letrozole
- Anastrozole
-
HER2 +: Monoclonal AB tx:
- Trastuzumab
- CARDIOTOXICITY
- Trastuzumab
- Pharmacology:
- Lumpectomy (w/ radiation) —> Mastectomy —> Regional removal of lymphnodes.
- Prevention:
- Tamoxifen/Raloxifen
- PostMenopausal or
- >35 with High Risk
Cystocele
Rectocele
- Risk Factors
- Management
Risk Factors:
- The Older you get the more kids you have the fatter you get.
Menopause
- Tx:
- Vasomotor insufficiency/ Hot flashes
- Vaginal Atrophy
- Osteoporosis
- Hormone Replacement Therapy
- E:
- Cessation of Menses >1 year due to Loss of Ovarian Function.
- P:
- Hot Flashes
- Dyspareunia
- Vaginal Atrophy
- Osteoporosis
- Dx:
- ^ FSH, ^ LH, v Estrogen ( ovarian follicles depletion)
- FSH assay most sensitive Initial Test
- Tx:
- Vasomotor insufficiency/ Hot flashes
- Estrogen/Progesterone
- Clonidine
- SSRI
- Gabapentin
- Vaginal Atrophy
- Estrogen topical
- Osteoporosis
- Calcium + VD
- weight-bearing exercise
- BISPHOSPHONATES
- Alendronate (Fosamax™, Fosamax™ Plus D)
- Risedronate (Actonel™, Actonel™ with Calcium, and Atelvia™)
- Ibandronate (Boniva™)
- Zoledronic acid (Reclast™)
- SERM
- Raloxifene
- CVA
- Pregnancy
- Tamoxifen
- ^ risk of Uterine Cancer past 5 years.
- Raloxifene
- Hormone Replacement Therapy
- Estrogen Only (Most Effective) (No Uterus)
- ^ Endometrial Cancer
- ^Thromboembolism
- Estrogen + Progesterone: (Yes Uterus)
- Protective against Endometrial Cancer
*
- Protective against Endometrial Cancer
- Estrogen Only (Most Effective) (No Uterus)
- Vasomotor insufficiency/ Hot flashes
Contraception
Spontaneous Abortion
Cervicitis
- Gonorrhea
- Chlamydia
- Herpes Simplex
- HPV
- Chlamydia:
- E: Chlamydia Trachomatis- MC std in US
- P: Cervical Motion Tenderness
- Dx: Nucleic Acid Amplification
- Gonorrhea as well
- Tx:
- Azithromycin/Doxy
- Ceftriaxone
Syphilis
Treatment:
- Primary, Secondary, Neuro
- See Rosh Review
Lymphogranuloma Venereum
E: Chlamydia infection
P: Genital/Rectal Lesion with softening, suppuration, and Lymphadenopathy
Dx:
Chancroid
- E: Haemophilus ducreyi
- P: Painful Ulcer: Papule–> Pustule –> Ulcer
- Lymphadenopathy
- Tx:
- Azithromycin
- Ceftriaxone
Premenstrual Syndrome
- E: Luteal Phase mood changes
- P:
- Physical
- Breast Swelling, Bloating
- Emotional
- Depression, Hostility
- Behavioral
- Food Craving, Poor Concentration
- Physical
- Dx:
- Sx start in Luteal Phase (1-2 weeks before menses)
- Relieved 2-3 days after menses
- 7 symptom-free days during the follicular phase
- Tx:
- SSRI
- OCP: induce Anovulation
Premenstrual Dysphoric Disorder
Severe PMS with functional impairment
“it is impairing their everyday life”
Amenorrhea
- Definition:
- Work UP
- Primary Amenorrhea
- Secondary Amenorrhea
- E:
- Pregnancy
- Hypothalamus Dysfunction
- Pituitary Dysfunction
- Ovarian Disorders
- Uterine Disorders
- Asherman’s Syndrome
- E:
Amenorrhea
- Definition:
- Absence of Menses
- Work up:
- Pregnancy Test
- serum Prolactin
- FSH, LH, TSH
- Primary Amenorrhea (Never had Menarche)
- 15yo - Sex Character
- 13yo- NO sex Character
-
Uterus/Breast Present:
- Outflow Obstruction (Blocking blood flow)
- transverse vaginal septum
- imperforate hymen
- Outflow Obstruction (Blocking blood flow)
-
Uterus(OK)/NO Breasts:
- ^FSH, ^LH –> Ovarian Cause
- Turners Syndrome (Gonadal Dysgenesis)
- vFSH, vLH –> Hypothalamus-Pituitary Failure
- ^FSH, ^LH –> Ovarian Cause
- Secondary Amenorrhea
- E:
- Pregnancy
- MC cause of secondary Amenorrhea.
- Hypothalamus Dysfunction
- E:
- Suppression of Hypothalamus
- Disorder of Hypothalamus
- Excessive Exercise
- Stress
- Nutritional Deficits
- Suppression of Hypothalamus
- Dx:
- normal/vFSR,vLH
- Tx:
- Clomiphene (SERM)
- E:
- Pituitary Dysfunction
- E: Prolactin-Secreting Pituitary Adenoma
- Dx:
- v FSH, LH, ^ PROLACTIN
- Prolactin inhibits GnRH
- Tx:
- Tumor Removal
- Ovarian Disorders
- E: Premature Ovarian Failure
- P:
- Symptoms of Menopause (Estrogen Deficiency)
- ^FSH & LH, v Estradiol
- Dx:
- Progesterone Challenge Test→ Causing Pseudo Mensis
- Tests:
- Adequate Estrogen
- Competent Endometrium
- Patent Outflow tract
- Pregnancy
- E:
By giving progestin you can see if the ovaries are producing any estrogen (ovarian cause), if the endometrium of the uterus has been scarred (uterine cause) or if there is an anatomic anomaly.
- Uterine Disorders
- Asherman’s syndrome= Acquired endometrial Scarring (postpartum hemorrhage, D&C).
Workup:
- Amenorrhea ==> Breast/No Breast and Uterus/No uterus==> FSH, LH, estrodiol levels ==> Hypo/Pit (
Normal Physiology
- When does Menstruation happen?
- What phase does Ovulation happen in?
- What causes GnRH to be secreted from Hypothalamus?
- Follicular Phase
- What does GnRH cause to be secreted?
- What prevents the release of more LH and FSH?
- Ovulation:
- What is the time frame when Ovulation happens?
- What happens to happen during ovulation
- Luteal Phase
- What predominates
- Where does progesterone come from?
*
-
Follicular Phase:
- 1-12 days
- Estrogen Predominates
- PULSATILE (the body stops the pulsatile secretion of GnRH when they don’t have enough stores in extreme athletes or poor nutrition)GnRH –> Pitutirary (FSH) & LH–> Overies –> Follicle Maturation (FSH) & Follicle Estrogen Secretion (LH)
- Estrogen BUILDS the endometrium
- NEGATIVE FEEDBACK of Estrogen on Hypothalamus.
-
Ovulation:
- ^ Estrogen from mature follicle –> Negative to Postive feedback—> ^ Estrogen, FSH, LH
- ^LH causes ovulation.
-
Luteal Phase:
- Progesterone predominates.
- Implantation occurs during this phase if there is fertilization.
- When does Menstruation happen?
- 1st day of the Follicular phase.
- < in estrogen/progesterone stops the negative feedback.
Ovarian Cancer
- Risk Factors
- Protective Factors
- Presentation
- Physical Exam
- Diagnosis
- What type of tissue?
- Management
-
Risk Factors
- Family History
- ^ # of ovulatory cycles
- Infertility, Nullparity
- >50yo/late menopause
-
Protective Factors
- OCP’s Protective by < number of ovulatory cycles
-
Presentation
- Asymptomatic until late in the disease
- Lower ABD pain/fullness /Irregular Menstruation……etc.
-
Physical Exam
- Palpable Mass +/- acites
- Diagnosis
- Biopsy- Epithelial
- Management
- ????????
Cervical Carcinoma
- Etiology
- Tissue types
- Risk Factors
- Presentation
- Diagnosis
- Treatment:
Staging:
Cervical Carcinoma
- Etiology:
- HPV 16,18, 31,32 (MC)
- 3rd MC Gynecologic Cancer
- Squamous 90%
- Adenocarcinoma 10%
- Risk Factors
- RF of PID/HPV
- Presentation
- Post Coital Bleeding/Spotting
- Diagnosis
- Colposcopy with Biopsy
- Treatment:
- Dependant on staging which determines the location of the tumor.
Staging:
- 0: Carcinoma In Situ: Excision/Ablation
- 1a: Microinvation: Surgery
- IIb-4a: metastasis to cervix, vagina, bladder, rectum.
- II: beyond the cervix but local
- II: lower 1/3 vagina
- IVa: Local METS: bladder rectum
- RADIATION + CHEMO
- 4b:
- Distant METS: Palliative radiation/chemo
Pap Smear Schedule
When do you start getting a pap smear
- 21yo –> 3 years
- >30 w/ negative –> 5 years
- >25yo + HPV –> Cytology & HPV test 12 month
- or Genotyoe for HPV 16,18
HPV Vaccination
- Age and number of does
- CI
- Gardasil Vaccine
- <15yo 2 doses q 6months
- >15 3doses over a minimum of 6 months.
- CI:
- Immunosuppressed, pregnant, lactating
Mammography Screening
- Mammography:
- Clinical Exam
- Self Exam
- When
- Mamography:
- 45-55: Annual Mamogram
- >55 q 2y
- Clinical Breast Exam:
- q 3y
- Self Exam:
- >20yo Monthly
- Immediately after Menstruation or:
- 5-7 days of the menstrual cycle.
Endometrial Cancer
- Etiology:
- Risk Factors:
- Protectives
- presentation:
- Diagnosis
- Tx:
- What is the Quick Picture
Endometrial Cancer
- Etiology:
- MC GYN Cancer in US
- Estrogen Dependent Cancer
- MC Postmenopausal Cancer
- Adenocarcinoma MC
- Risk Factors:
- ^ Estrogen Exposure
- Tamoxifen:
- decreases estrogen in the breast but increases in the uterus and bones.
- Protectives:
- OCP’s protective for Endometrial Cancer and Ovarian Cancer
- Presentation:
- Postmenopausal Bleeding
- Diagnosis
- Endometrial Biopsy
- Ultrasound
- Endometrial Stripe>4mM
- Tx:
- Stage I: Hysterectomy
-
QUICK PICTURE:
- Postmenopausal
- Vaginal Bleeding
- Dx: Endometrial Biopsy
- Adenocarcinoma MC
- Tx: Complete Hysterecotmy