OB/GYN Flashcards
H/o DVT rules out what contraception options?
anything containing combination of estrogen and progestin
Define typical use effectiveness and perfect use effectiveness
Typical use effectiveness- overall effectiveness in actual use when forgetfulness and misuse occur
Perfect use effectiveness- efficacy when used correctly, consistently and reliably
What is the yuppie method?
OCP regimen consisting of 2 tablets of 100-120 mug of ethinyl estradiol and 500-600 mug of levonorgosterol at time zero and 2 tablets after 12 hrs
What is plan B?
Levonorgestrel 0.75 mg PO at time 0 and the same dose after 12 hrs (method used within 72 hours of unprotected sex)
Plan B one-step
levonergosterol 1.5 mg taken as one pill
What is the most effective contraception to protects against STDs?
male condoms; this is the second most common form of contraception used
What are the disadvantages with a vaginal diaphragm?
it must be fitted by a physician; placed 1-2 hours before sex and left in 8 hours afterwards
There is an increased rate of UTIs and increased risk of ulceration of the vagina with prolonged use
Cervical caps are limited in use because women with ____ should not use them.
abnormal cervical cytology; due to fear of traumatizing the cervix
What is the function of the progestin and estrogen in OCPS?
progestin- thickens the cervical mucous and inhibits ovulation
Estrogen- maintain the endometrium, prevent unscheduled bleeding, and prevent follicular development
What risks are involved with OCPs (primarily due to estrogen)?
Venous thromboembolism
Stroke in pts with migraines with aura
MI in heavy smokers (>15 cigarettes per day) and who are 35 or older
What are the non-contraception benefits of OCPs?
Decreased risk of ovarian, colon, or endometrial cancer
Shortened duration of menses
Decreased bleeding during menses
Improved pain from dysmenorrhea and endometriosis
Decreased abnormal uterine bleeding
Improving acnes
T/F: Depot (DMPA) is just as effective as LARCs.
F- depot has a higher pregnancy rate than LARC
What medication is in the contraceptive patch?
norelgestromin and ethinyl estradiol
What medication is in the contraceptive arm implant?
etonogestrel
What is the time period after stopping contraception needed to regain fertility?
Pills, patches, rings- 2 weeks
Injectables-9-10 months
postpill amenorrhea may persist for ____ amount of time
6 months
How long can the IUDs be in place for?
Cooper T380A- 10 yrs
Mirena- 5 years
Skyla- 3 years
Liletta- 3 yrs
What are the non contraceptive uses for levonorgestrel IUDs?
tx pts with menorrhagia, dysmenorrhea, and pain due to endometriosis, and adenomyosis
What risks are there with IUD insertion?
uterine perforation in 1:1000
transient increase in upper GU infection (1:1000) due to endometrial contamination
Contraindication to IUD insertion
current pregnancy, current STD, PID currently or within the past 3 months, unexplained vaginal bleeding, malignant gestational trophoblastic disease, untreated cervical cancer, untreated endometrial cancer, uterine fibroids distorting the endometrial cavity, current breast cancer (for levonorgestrel IUDs), anatomical distortions of the uterine cavity, known pelvic TB, allergy to IUD component, Wilson’s dx (Copper IUD)
What are the forms of emergency contraception?
Progestin Plan B, Plan B One-Step, ulipristal are the three most common forms. Also includes the copper IUD and the Yuzpe method
True/false – there are no medical conditions were the risk of emergency contraception outweighs the benefits.
True-woman with cardiovascular disease, migraines, liver disease, or who are breast-feeding may use emergency contraception.
What is the major side effect of emergency contraception?
Nausea and vomiting
When is emergency contraception contra indicated?
In women with suspected or known pregnancy, are those with abnormal vaginal bleeding
What effect does Depot have on bones in adolescence?
Depot Is associated with the loss of bone mineral density particularly in adolescence. If it is the best type of contraception for the patient, the loss and bone mineral density should not discourage the use of the agent.
True/false – oral contraceptives decrease the risk of benign breast disease
True
OCPs may cause a slight increase in ____ and ______.
Risk of breast cancer and incidence of gallstones
What birth control method is best suited for breast-feeding females?
Progestin only pill- e.g. Minipill
What birth control method is best suited for patients with sickle cell disease or epilepsy?
Injectables like Depot
What form of contraception may lead to more bleeding or dysmenorrhea?
Copper IUD
Of the three most common causes of infectious vaginal discharge, which etiology is not inflammatory?
Bacterial vaginosis
What is the treatment of bacterial vaginosis?
Antibiotic therapy targeting anaerobes such as metronidazole are clindamycin
What are the diagnostic criteria for a bacterial vaginosis?
Three out of four Amsel’s criteria are indicative of bacterial vaginosis: 1. Homogeneous gray white discharge 2. Vaginal pH greater than 4.5
3. Positive whiff test 4. Clue cells on wet mount
Gram stain is considered the gold standard for diagnosis, but is rarely used.
Bacterial vaginosis is associated with what genital tract infections and pregnancy complications?
Endometriosis, PID, preterm delivery, and preterm premature rupture of membranes
What STD can survive for up to six hours on a wet surface?
Trichomonas vaginalis
What is the most common symptom associated with trichomoniasis?
Profuse frothy Yellow– Green to gray vaginal discharge or vaginal irritation
What can cause trichomonads on a wet mount to have decreased movement?
If the wet mount is cold or there are excess leukocytes present
What is the treatment for trichomoniasis?
A fairly high dose of metronidazole (2 g) as a one time dose, with the partner treated as well.
Why is vaginal metronidazole not effective in the treatment of trichomoniasis?
Vaginal metronidazole results in low therapeutic levels of the drug in the urethra or Skene’s glands were trichomonads may reside
In a healthy vagina what prevents the growth of fungus?
The native lactobacilli; this explains why anabiotic therapy may result in Candida overgrowth
Typical presentation: intense vulvar or vaginal burning, irritation and swelling
Candidal vaginitis
Candidal vaginitis treatment
Oral fluconazole/Diflucan or topical imidazoles such as Terconazole/terazol, miconazole/ Monistat, and clotrimazole/ lotrimin
What are the most common side effects with metronidazole?
G.I. including nausea, abdominal discomfort, bloating or diarrhea
Which forms of vaginitis are associated with alkaline pH and positive whiff test?
Bacterial vaginosis and trichomoniasis
Uncomplicated cystitis treatment
Three day course of trimethoprim/sulfa (Bactrium)
If a patient with UTI symptoms has a urine culture that demonstrates no growth of organisms, but symptoms persist what is the most likely diagnosis?
Urethritis often caused by chlamydia, candidalvulvovaginitis, or urethral syndrome
What is urethral syndrome?
Recurrent episodes of urgency and dysuria caused by urethral inflammation of unknown cause; Urine cultures are persistently negative
Gross hematuria should raise the suspicion of _____
Nephrolithiasis
True/False – fever is common with a UTI
False- fever is uncommon unless there is upper urinary tract/kidney involvement
What is the definition of bacteriuria?
More than 100,000 colony forming units per milliliter of a single uropathogen obtained from a midstream voided clean catch urine culture
If the patient is symptomatic, as few as 1000 colony forming units per milliliter may be significant.
On a catheterized patient, 10,000 colony forming units per milliliter is considered bacteriuria
What is the most common form of UTI?
Simple cystitis
List the antibiotics that are effective in treating simple cystitis
(Trimethoprim/sulfa) Bactrim, nitrofurantoin, ciprofloxacin, norfloxacin, fosfomycin
What are the three most common causes of urethritis?
Chlamydia, gonorrhea, trichomoniasis
How should urethritis be diagnosed?
Gram stain and culture of the urethra for gonococcus and chlamydia, with confirmatory nucleic acid amplification testing (NAAT)
Urethritis treatment
Empiric treatment for chlamydia with doxycycline; if gonorrhea is suspected, intramuscular ceftriaxone with oral doxycycline is usually curative. If treating a pregnant woman azithromycin should be substituted for doxycycline
Typical presentation: nausea, vomiting, fever, chills, flank pain
Pyleonephritis
Mild Pyelonephritis in non pregnant woman treatment
Oral Bactrim or a fluroquinolone for 14 day course; women should be re-examined within 48 to 72 hours
When should a woman with Pyelonephritis be hospitalized?
Those who are not beginning to clinically improved, are more toxic, unable to take oral medications, pregnant, or immunocompromise should be hospitalized and treated with IV anabiotics
Treatment of pyleonephritis in a hospitalized patient
Treatment and patience bad enough to warrant hospitalization – IV anabiotic’s such as ampicillin and gentamicin, third generation cephalosporin such as ceftriaxone, fluroquinolones, the carbapenems, or piperacillin – tazobactam
Management of a pregnant patient following resolution of fever and symptoms from acute Pyelonephritis
Suppressive antibiotic therapy for the remainder of the pregnancy– Such as nitrofurantoin Macrocrystals 100 mg once daily
Upper UTIs increase the risk of _____ in pregnant women
septicemia, kidney dysfunction, or preterm labor
Asymptomatic bacteriuria has a high incidence in women with ______
Sickle cell trait
What is the hCG threshold at which a intrauterine pregnancy should be seen with transvaginal sonography?
1500 to 2000 mIU/mL
In a normal pregnancy what should happen to the hCG levels in 48 hours?
Follow up hCG at 48 hours should rise at least by 66%. If the follow up hCG does not rise by 66% particularly if it rises by only 20% then the patient most likely has an abnormal pregnancy
True/false – a subnormal rise in hCG indicates that an abnormal pregnancy exist outside of the uterus
False – a subnormal rise in hCG does not indicate whether the abnormal pregnancy is in the uterus or the tube
Following a complete abortion what should happen to the hCG levels?
HCG level should be cut in half every 48 to 72 hours
Following a complete abortion what does a hCG plateau indicate?
If the hCG level plateaus rather than falling, then the patient has residual pregnancy tissue
True/false – spontaneous abortions are more common in older patients.
True
What is the most common identifiable cause for spontaneous abortion?
Chromosomal abnormality of the embryo
Define. Threatened abortion
Pregnancy with vaginal spotting during the first half of pregnancy; this does not delineate the viability of the pregnancy
Define: inevitable abortion
Cramping, bleeding, and cervical dilation without passage of tissue in a pregnancy less than 20 weeks
Define: incomplete abortion
Cramping, vaginal bleeding, and open cervical os, and some passage of tissue per vagina with remaining tissue in utero in a pregnancy less than 20 weeks. The cervix remains open and the uterus continues to contract
Define: completed abortion
A pregnancy less than 20 weeks in which all the products of conception have passed and the cervix is generally closed. Because all of the tissue has been passed, the uterus no longer contracts, and the cervix closes
Define: missed abortion
My pregnancy less than 20 weeks with embryonic demise no symptoms such as a bleeding or cramping
What percentage of threatened abortions result in viable intrauterine pregnancy?
50%
A single progesterone level more than ____ almost always indicates a normal intrauterine gestation
25 ng/mL
A single progesterone level less than ____usually correlates with a non-viable gestation
5ng/mL
True/false –Abnormal hCG rise or single progesterone less than five means a non-viable pregnancy is diagnosed; however, it is still unclear whether the patient has a spontaneous abortion ectopic pregnancy
True
When a non-viable pregnancy is diagnosed either by abnormal rising hCG or a single progesterone less than five, what is the next step in distinguishing miscarriage from ectopic pregnancy?
Most physicians perform a uterine curettage; if chorionic villi are present the patient had a miscarriage. If chorionic villi are absent the patient had an ectopic pregnancy.
What is the treatment for small ectopic pregnancies?
Asymptomatic, small (less than 3.5 cm) ectopic pregnancies are ideal candidates for intramuscular methotrexate
What is the management of a non-viable intrauterine pregnancy?
Manage expectantly, surgically via dilation and curettage or medically with vaginal misoprostol
Rh negative women with ____, _____, or ______ should receive RhoGAM to prevent isoimmunization
Threatened abortion, spontaneous abortion, or ectopic pregnancy
How can an inevitable abortion be differentiated from an incompetent cervix?
With an insufficient cervix, the cervix opens spontaneously without uterine contractions. However, in inevitable abortion uterine contractions lead to cervical dilation.
Incompetent cervix treatment
Cerclage – a surgical suture at the level of the internal cervical os
Missed or incomplete abortion treatment
Expectant management for passage of tissue, medical management with mifepristone misoprostol, and surgical management with dilation and curettage of the uterus for immediate definitive treatment
What is the primary complication of retained tissue from an incomplete abortion?
Bleeding and infection
Management of a patient with threatened abortion, hypotension/volume depletion, severe abdominal/pelvic pain or adnexal mass
Consider a laparoscopy or laparotomy due to high possibility of ectopic pregnancy
Management of a patient with threatened abortion, HCG more than 1500, no interuterine pregnancy seen on transvaginal ultrasound
Consider a laparoscopy
Management of a patient with threatened abortion, hCG less than 1500
Ultrasound is optional and repeat hCG in 48 hours
Management of a patient with threatened abortion, no acute signs of ectopic pregnancy, hCG less than 1500, Repeat hCG reveals abnormal rise
Diagnosis: probable non-viable pregnancy; uterine curettage – chorionic villi seen versus no villi seen
No villi seen -diagnosis ectopic pregnancy; consider methotrexate
Chorionic villi seen- diagnosis miscarriage
Typical presentation: vaginal spotting, absence of fetal heart tones, size greater than dates, and markedly elevated hCG levels
Molar pregnancy
Molar pregnancy treatment
Uterine suction curettage; patients followed with weekly hCG levels because sometimes gestational trophoblastic disease persist after evacuation of the molar pregnancy. In this case chemotherapy is used.
Incompetent cervix risk factors
Cervical conization, congenital (short cervix or collagen disorder), trauma to the cervix, prolonged second stage of labor, and uterine overdistention as with a multiple gestation pregnancy
List the two most common causes of antepartum bleeding
Placenta previa and placenta abruption
What is the most common cause of a first trimester miscarriage?
Fetal karyotypic abnormality
True/false – enlarged uterus does not exclude the diagnosis of an ectopic pregnancy
True – hCG has an affect on the uterus regardless if the pregnancy is interuterine or ectopic
Define: heterotopic pregnancy
When both and interuterine pregnancy and an act topic pregnancy exist at the same time; risk 1:10,000
this is why the proof of an interuterine pregnancy decreases the likelihood of an ectopic pregnancy
Management of a patient with hCG more than 1500, no intrauterine pregnancy seen on transvaginal ultrasound
The risk of extra uterine pregnancy is high but it is not 100%. Therefore, laparoscopy is indicated and not methotrexate
What is the location of the majority of ectopic pregnancies?
97% involve the Fallopian tube
What is the most common reason for maternal mortality in the first 20 weeks of pregnancy?
Hemorrhage from ectopic gestation
Typical presentation: abdominal pain, amenorrhea of 4 to 6 weeks, irregular vaginal spotting
Ectopic pregnancy
Typical presentation: acute worsening of Abdominal pain, syncope, shoulder pain, tachycardia, hypertension, orthostasis, hemoperitoneum
Ruptured ectopic pregnancy
Risk factors for ectopic pregnancy
Salpingitis particularly with chlamydia, tubal adhesive disease, infertility, progesterone secreting IUD, tubal surgery, prior ectopic pregnancy, ovulation induction, congenital abnormalities of the tube, assisted reproductive technology
Which is more sensitive transvaginal sonography or trans abdominal sonography?
Transvaginal sonography – can detect pregnancies as early as 5.5 to 6 weeks
Define: pseudo gestational sac
irregularly shaped fluid collection in the midline of the uterine cavity seen in some ectopic pregnancies
Distinguished from a normal gestational sack because these or eccentrically located and have a decidual sign
When is a salpingectomy performed for ectopic pregnancies?
Gestations too large for conservative therapy, when rupture has occurred, or for those women who do not want future fertility.
During a salpingostomy, why is the incision on the tube not reapproximated?
Suturing may lead to structure formation
Follow up after salpingostomy
There is a 10 to 15% chance of persistent ectopic pregnancy. Therefore, serial hCG levels should be followed
When is methotrexate used for ectopic pregnancy?
Ectopic Pregnancy is less than 3.5 cm in diameter, without fetal cardiac activity, and hCG levels less than 5000
Following one dose of methotrexate, what should be done if the hCG level does not fall?
Methotrexate leads to resolution in 85 to 90% of cases. However, a second dose is required if the hCG level does not fall
Hypotension, worsening or persistent pain, or a falling hematocrit after methotrexate treatment may indicate what?
Tubal rupture which will necessitate surgery
What is indicated when hCG levels plateau in the first eight weeks of pregnancy?
An abnormal pregnancy – may be either a miscarriage or an ectopic pregnancy
True/false – spotting and lower abdominal pain can be a normal occurrence in pregnancy especially very early in the first trimester
True
Define: latent phase of labor
The initial part of labor where the cervix mainly effaces/thins rather than dilates. Cervical dilation less than 6 cm
Define: active phase of labor
The portion of labor were dilation occurs more rapidly; cervix is more than 6 cm dilated
Define: arrest of active phase of labor
No progress in the active phase of labor with ruptured membranes for four hours with adequate contractions, or six hours of inadequate contractions
What are the stages of labor?
First stage: onset of labor through the complete dilation of cervix
Second stage: complete cervical dilation through the delivery of infant
Third stage: delivery of infant through delivery of placenta
Define: normal fetal heart rate, fetal bradycardia, fetal tachycardia
Normal: between 110 and 160 bpm
Fetal bradycardia: baseline less than 110 bpm
Fetal tachycardia: heart rate exceeding 160 bpm
What are the three types of Decelerations?
Early: mirror image of uterine contraction due to compression of fetal head
Late: Deceleration offset following the uterine contraction that indicate fetal hypoxia
Variable: abrupt jagged dips below the baseline caused by cord compression
Define: acceleration
Episodes of the fetal heart rate increasing above the baseline for at least 15 bpm and last for at least 15 seconds
Normal labor parameters in a nullipara Woman
Latent phase: less than or equal to 18 to 20 hours
Active phase: continued progress
Second stage of labor: less than or equal to three hours or less than or equal to four hours if epidural used
Third stage of labor: less than or equal to 30 minutes
Normal labor parameters a multipara woman
Latent phase: less than or equal to 14 hours
Active phase: continued progress
Second stage of labor: less than or equal to two hours or less than or equal to three hours if epidural used
Third stage of labor: less than or equal to 30 minutes
When an abnormal labor is diagnosed what three categories should be considered?
Powers, pelvis, and passenger
When it is determined that the power is the issue, what is the treatment?
Oxytocin
Define: clinically adequate uterine contractions
Contractions every 2 to 3 minutes, firm on palpation, and lasting for at least 40 to 60 seconds
How can the adequacy of the powers be assessed?
Internal ureter catheters can evaluate the adequacy of the powers. One common assessment tool is to examine a 10 minute window and add each contraction’s rise above baseline (each mm Hg rise is called a Montevideo unit); 200 Montevideo units is commonly accepted as an adequate uterine contraction pattern.
What are the most common decelerations?
Variable
What can late decelerations occurring in more than 50% of uterine contractions indicate?
Fetal acidemia
When late decelerations occur together with decreased variability, then _____ is strongly suspected.
Acidosis
Define: category I, category II, and category III fetal heart rate patterns
Category I: Reassuring – normal baseline and variability, no late or variable decelerations
Category II: needs watching – may have some aspect that is concerning but not Ominous; for example Fetal tachycardia without decelerations
Category III: ominous and indicates a high likelihood of severe fetal hypoxia or acidosis– examples include absent baseline variability with recurrent late or variable decelerations or bradycardia, or sinusoidal heart pattern (this requires prompt delivery if no improvement)
Management of arrest disorder (no change in active phase of labor for four hours)
Assess three Ps; if adequate contractions for four hours with rupture of membranes and cervix is dilated more than 6 cm OR inadequate contractions for six hours with rupture of membranes and cervix dilated more than 6 cm–> c-section
If the above criteria are not met, give oxytocin and reassess
What are the two most common reasons for a C-section?
Labor dystocia in 34% of cases and an abnormal fetal heart rate in 23% of cases
How does the safety of a C-section compare to vaginal delivery?
C-section has a higher overall severe morbidity or mortality rate, and a 3.5 fold increase risk of mortality
Management of category III tracings
Require prompt intervention – if prompt interuterine resuscitation maneuvers are not curative, imminent delivery is prudent
What conditions are associated with category III tracings?
these tracings are associated with low pH, hypoxia, and encephalopathy, and cerebral palsy
Most fetal heart rate tracings fall in which category?
II – which can span from reassuring fetal heart rate tracing versus a tracing that is worrisome
Scalp stimulation inducing ____ highly correlates to a normal umbilical cord pH (greater than or equal to 7.2).
An acceleration
What are the 6 causes for prolonged decelerations?
Tachysystole, hypotension, rapid cervical dilation, umbilical cord prolapse, placental abruption, uterine rupture
Define: prolonged decelerations
Decelerations lasting between 2 and 10 minutes
Define tachysystole. What is the intervention?
More than 5 contractions per 10 minutes averaged over 30 minutes; decrease or stop oxytocin, or administer beta-mimetic agent
If hypotension following anesthesia or epidural causes prolong decelerations, how should this be managed?
IV fluid bolus, or administer vasopressor agents such as ephedrine
If rapid cervical dilation is causing prolonged decelerations, how should this be managed?
Positional changes and observation
Management of umbilical cord prolapse
Elevate presenting part and emergency C-section
If placental abruption is causing prolonged decelerations, how should this be managed?
Support BP, stabilize patient, consider C-section if progressive
If uterine rupture is causing prolonged decelerations, how should this be managed?
Emergency C-section
True/false – IV oxytocin aids in cervical dilation, and enhances contraction strength and/or frequency
False – IV oxytocin does not affect cervical dilation. It does however enhance contraction strength and/or frequency
Define: anthropoid pelvis
A pelvis with an anterioposterior diameter greater than the transverse diameter with prominent ischial spines and a narrow anterior segment, which predisposes to the persistent fetal occiput posterior position
Define: station
Refers to the relationship of the presenting bony part of the fetal head in relation to the ischial spines, and not the pelvic inlet
Define: engagement
Refers to the relationship of the widest diameter of the presenting part and its location with reference to the pelvic inlet
Define bloody show
Loss of the cervical mucus plug; a sign of impending labor
Delivery before 39 weeks gestation is associated with an increased risk of neonatal complications including…
Increased incidence of NICU admission, respiratory difficulties, sepsis, hyperbilirubinemia, Ventilator use, and hospital stay exceeding five days
Management of prolonged latent phase of labor
Observation and Oxytocin
Management of repetitive deep variable decelerations
Amnioinfusion
What is the most common abnormal karyotype encountered in spontaneous abortions?
Autosomal trisomy
What can be given for pregnancy is less than 32 weeks for Neuroprotection?
Magnesium sulfate
A single examination revealing _________ and _______ in a nulliparous woman would be sufficient to diagnose preterm labor.
2 cm dilation and 80% effacement
Explain what a positive and negative result on fetal fibronectin indicates.
A positive result indicates risk of preterm birth whereas a negative result is strongly associated with no delivery within one week
Treatment for Preterm labor
Intramuscular antenatal steroids to enhance fetal pulmonary maturity in a pregnancy less than 34 weeks
Tocolysis unless there is a contraindication such as inter-amniotic infection or severe preeclampsia
IV antibiotics such as penicillin in the case that delivery cannot be prolonged to help reduce the likelihood of GBS sepsis
Magnesium sulfate in pregnancies less than 31 weeks and six days for neurodevelopment, Reducing cases of cerebral palsy in preterm infant
Define: preterm labor
Cervical change associated with uterine contractions prior to 37 weeks and after 20 weeks
What are the four most common tocolysis agents used?
Indomethacin, nifidepine, terbutaline, ritodrine
Cervical length of less than ____ millimeters results in an increased risk of preterm delivery
25
Define: late preterm gestation
Delivery that occurs between 34w0d and 36w6d
This category comprises most preterm deliveries
What is the most significant risk factor for preterm delivery?
History of a prior spontaneous preterm birth
Symptoms of preterm labor
Uterine contractions, abdominal tightening, pelvic pressure, increased vaginal discharge