O&T: Upper Limb Painful Conditions Flashcards

1
Q

Upper limb painful conditions

A

Classification:
- Acute / Subacute / Chronic
- Shoulder / Elbow / Hand / Wrist

Acute:
- Infection
- Trauma / Fracture

Subacute / Chronic:
- Overuse conditions
- Inflammatory conditions
- Degenerative conditions

4 Subcategories:
1. Overuse conditions
- Tennis elbow
- Golfer’s elbow
- De Quervain disease
- Trigger finger

  1. Wrist pain / Wrist sprain
    - ECU
  2. Inflammatory arthritis
    - RA
    - Gout
    - Other sero-negative arthropathies
  3. Osteoarthritis
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2
Q

Overuse conditions

A
  • Very common in primary care, sports medicine, occupational medicines, orthopaedic practice
  • Very heterogeneous group of diseases
    1. Tennis elbow
    2. Golfer’s elbow
    3. De Quervain disease at wrist
    4. Trigger finger

Cause: Unknown

Pathogenesis:
Mechanical overload, Micro-trauma
—> Inflammation —> Try to Heal
—> Continuous inflammation + healing
—> Tissue damage
—> Degeneration, Rupture

Pathology:
1. Tendon involvement
- Tennis elbow
- Golfer’s elbow

  1. Surrounding tissue around tendon
    - De Quervain disease at wrist
    - Trigger finger

Diagnosis:
- History
- Clinical examination

Investigations (not much needed):
- X-ray (for malalignment)
- Ultrasound / MRI (for confirmation of diagnosis / see involvement of which tissue)

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3
Q

Etiology of Overuse conditions

A

Often multi-factorial, some factors maybe more important in one patient than other

  1. Extrinsic factors:
    - Repetitive mechanic load
    - Equipment problems (e.g. wrong tennis racquet)
    - Drugs (e.g. steroids)
  2. Intrinsic factors
    - Anatomic factors
    —> Malalignment
    —> Joint inflexibility
    —> Joint laxity
    —> Muscle weakness
    —> Muscle imbalance
  • Age-related factors
    —> Tendon degeneration
    —> ↓ Vascularity
    —> ↑ Tendon stiffness
    —> ↓ Healing response
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4
Q
  1. Tendon involvement
A
  • Characterised by **Degeneration
    —> Inflammatory cell infiltration seems to be **
    absent in chronic tendon injury
  • Common in ***bone-tendon insertion

Pathology:
- **Tennis elbow
- **
Golfer’s elbow

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5
Q
  1. Surrounding tissue around tendon
A
  • Inflammation of tendon sheath
  • Tendon unaffected

Tissue affected:
- **Tendon sheath
- **
Peritendinous tissue

Pathology:
- **Tenosynovitis (Inflammation of synovium that surrounds a tendon)
- **
Peritendinitis

Examples:
- **De Quervain disease
- **
Trigger fingers

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6
Q

Tennis Elbow

A

aka **Lateral epicondylitis
- Painful condition involving **
tendons that attach to the bone on the lateral elbow (Lateral epicondyle)
- Muscle involved: Extensor Carpi Radialis Brevis (ECRB) (help extend + stabilise wrist)
—> Degeneration of tendon attachment of ECRB

Mechanical overload:
- Occurrence correlates with time of tennis playing
- Occur with many different types of activities (non-work / work-related) and sports activities

Pathophysiology:
- Activities that causes stress on ***Extensor muscle-tendon unit
—> Stress on tendon attachment
—> ↑ Strain to tendon
E.g.
- Hold too large a racquet grip
- Meating cutting
- Plumbing
- Painting
- Weaving

Clinical features:
- 30-50 yo
- M=F
- Pain on **outside aspect of elbow
- Pain starts at **
elbow —> down to forearm —> hand
- Produced by any activity which places stress on tendon e.g. **Gripping / **Lifting

Signs:
- Tenderness at **Lateral epicondyle of elbow
- Pain elicited by **
moving elbow
- Pain on ***resisted wrist extension (DDx: Radial head OA)

DDx (SpC Revision):
1. C6 / C7 radiculopathy
2. PIN syndrome (Posterior interosseous nerve syndrome)
3. Radial head OA

Treatment:
1. Rest
2. **Counter force strap
3. **
Steroid + LA injection
4. Operation

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7
Q

Golfer’s elbow

A

aka **Medial epicondylitis
- less common
- Painful tendinitis on **
inner aspect of elbow
- at the origin of “Flexor / Pronator” muscles (i.e. Medial epicondyle)

Mechanical overload:
- Repeated **swing stress to elbow
- Heavy lifting / Hammering
- Sport activities that involve a lot of **
throwing e.g. Archery, Baseball, Softball, Javelin
- Repeatedly use ***wrist / clench fingers (flexion) e.g. Weight training

Clinical features:
- >35 yo
- M=F
- Pain / Tenderness on **medial epicondyle
- Elbow stiffness (sometimes)
- Pain when try to make a **
fist, **swing golf club, turn doorknob, lift weight, pick up something with palm down (pronation), **flex wrist
- Weakness in ***hand and wrist

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8
Q

De Quervain disease

A

Stenosing Tenosynovitis of 1st Extensor compartment of wrist
- **
Extensor Pollicis Brevis (
EPB)
- *Abductor Pollicis Longus (
APL)
(aka 媽媽手)

Epidemiology:
- Occurs most commonly in women in their sixth decade of life
- Increase incidence in patients with Dupuytrens’ disease, RA, gout or DM
- Bilateral involvement in 30% of patients

Clinical features:
- **Middle-aged women
- Repetitive activities e.g. **
Keyboarding, Assembly line work, Carpentry, ***Lifting newborn babies
- Pain / Swelling in radial wrist
- Aggravated by thumb motion
- Pain often radiates up to the forearm or down to the thumb

P/E:
- Tenderness over **radial styloid
- **
Finkelstein test: Ulnar deviation of wrist with fist formed around thumb stretches EPB, APL tendon —> causes pain over styloid process

Treatment:
1. Conservative
- Injection
- Splintage

  1. Surgery
    - Decompression
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9
Q

Trigger finger

A

Aka ***Flexor Stenosing Tenosynovitis

Pathophysiology:
- Chondrocytes proliferation —> ↑ Extracellular matrix —> Fibrocartilage metaplasia in **A1 pulley of Flexor tendon (*MCP joint) —> Size disproportion between a flexor tendon and its tendon sheath

Clinical features:
- 50-60 yo
- F>M
- Dominant hand
- Thumb, (Middle), Ring finger most affected

Pathology:
- Primary (Idiopathic)
- Secondary:
—> **Carpal tunnel syndrome (18-23%)
—> **
De Quervain’s disease
—> DM
—> ***RA
—> Dupuytren’s contracture
—> Giant cell tumour, Schwannoma

Risk factors:
- **Repetitive grasping —> **thickening of pulley
- ***Occupation

Grading:
Grade 1: Pre-triggering
- pain in A1 pulley

Grade 2: Active triggering
- active extension

Grade 3: Passive triggering
- 3a: need passive extension
- 3b: unable active extension

Grade 4: Contracture
- fixed flexion contracture of PIPJ

Treatment:
1. Conservative
2. Steroid (SE: discolouration of skin) / LA injection (SpC Revision)
3. Surgical release (open / percutaneous)

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10
Q

Treatment for Overuse conditions

A

Conservative treatments
1. Avoidance of mechanical overload
2. Activity modification, Change occupation
3. Appropriate protective device
4. ***Physiotherapy
- stretching / strengthening exercise (esp. if muscle imbalance)
- USG / heat treatment (to ↓ pain)

  1. ***Intermittent splintage
    - tennis elbow brace
    - ↓ tension on tendon —> allow it to heal
  2. Extracorporeal shock wave therapy
    - no level 1 evidence
    - persistent calcifying tendinitis of shoulder —> 62% partial / complete disintegration of deposit —> functional improvement
    - some success in 50-60% tennis elbow patients
  3. ***NSAID
    - short term effect as analgesic
    - ∵ no inflammation in some overuse conditions —> unclear whether NSAID can alter the natural history of tendinopathies
  4. **Steroids
    - oral steroid: NO proven benefit
    - **
    Local injectable steroid
    —> minimal invasive
    —> high initial success rate
    —> risk: possibility of **steroid atrophy + **tendon rupture (if inject >=3 times), recurrence, complications

Surgery
- Failure of conservative treatment
- Significant symptoms affecting ADL / Secondary joint contracture
- Percutaneous vs Arthroscopic vs Open

  1. Tendon
    - **Debridement of degenerative tendon
    - Reinsertion
    - **
    Repair
    - ***Tendon grafting (if whole tendon degenerated)
  2. Tendon sheath
    - **Synovectomy
    - **
    Retinaculum release
  3. Excision of bony structure
    - if bony malalignment
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11
Q

Wrist pain

A

Often caused by ***Trauma instead of Overuse

Ulnar side:
1. Extensor Carpi Ulnaris (ECU) tendonitis / dislocation
2. Distal Radioulnar Joint (DRUJ) subluxation / dislocation (∵ Triangular fibrocartilage complex (TFCC) tear)

Radial side:
3. **Scapholunate ligament tear
4. +/- **
Scaphoid fracture

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12
Q
  1. ECU tendonitis / subluxation
A

Extensor Carpi Ulnaris (ECU):
- **6th Extensor compartment of wrist
- Strong stabiliser of **
wrist (Extend + Adduct wrist)

ECU tendonitis:
- Pain along extensor tendon
- ***ECU synergy test: Supinated forearm
—> spread out Thumb, Index, Middle finger
—> grasps patient’s thumb and long finger with one hand, palpates the ECU tendon with the other hand
—> the patient abduct the thumb against resistance (which require ECU to stabilise joint / keep wrist in extension)
—> Recreation of pain along dorsal ulnar aspect of wrist: Positive result

ECU subluxation:
- ECU tendon subluxed over ulnar styloid when in Supination, recover when Pronation
- Snapping of wrist
- Repetitive subluxation —> ECU tendonitis
- Treatment: ***ECU pulley reconstruction

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13
Q
  1. TFCC tear
A

Triangular fibrocartilage complex:
- Strong stabiliser of ***Distal Radioulnar Joint (DRUJ)
—> Tearing
—> DRUJ Subluxation

Causes:
- Falling on outstretched hand —> younger people few distal-radius fracture —> DRUJ instability instead

Clinical features:
- Pain when rotating forearm

Treatment: TFCC repair / reconstruction

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14
Q
  1. Scapholunate ligament tear
A

(Scapholunate ligament: (from youtube)
- Strong ligament between Scaphoid and Lunate bone
- Stabiliser of wrist)

Diagnosis:
***Watson test:
- Grasps the wrist with their thumb over Scaphoid tubercle (volar aspect of the palm) in order to prevent the scaphoid from moving into its more vertically oriented position in ulnar deviation
- Wrist in slight extension —> move from ulnar to radial deviation —> release thumb over scaphoid —> examiner will feel a significant ‘clunk’ and patient will experience pain
- If SL ligament disrupted —> Scaphoid will subluxate over the dorsal lip of distal radius

Treatment:
- **Scaphoid fixation
- **
SL repair
- Bone graft if non-union

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15
Q
  1. Scaphoid fracture
A
  • Easily missed
  • Radial wrist pain
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16
Q

Treatment of Wrist pain

A
  1. Rest
  2. Splintage / Cast
  3. Physiotherapy
  4. Surgery
    - for high demand patients e.g. Athletes
    - affect ADL
    —> Debridement
    —> Repair
    —> Reconstruction
    E.g. ECU pulley reconstruction, TFCC repair / reconstruction, Scaphoid fixation / SL repair
17
Q

Inflammatory conditions / Systemic autoimmune disorders

A
  • Affecting multiple joints
  • Hands, Wrists, Elbows
  1. RA
  2. Gout
  3. Psoriatic arthritis
18
Q
  1. RA
A
  • Inflammatory arthritis of synovial joints
  • Systemic chronic inflammatory disease
  • Proliferative synovium (***Pannus) erodes into surrounding structures:
    —> Articular cartilage
    —> Bone
    —> Ligament
    —> Tendon

Epidemiology:
- 0.3-0.4% in HK
- F:M = 3:1
- Age of presentation: 4-5th decade
- Very strong familial hereditary history
—> ***HLA DR4, DR1
—> 1st degree relative 3x risk

Pathogenesis:
Injury to synovial microvascular endothelial cells
—> Trigger inflammatory reaction
—> Influx of PMN leukocyte, monocytes, macrophages
—> Inflammatory mediators produced
—> Stimulate osteoclasts
—> **Subchondral osteopenia (Inflammation of joint —> Pain + Swelling —> Immobilisation —> further enhance osteopenia)
—> **
Joint destruction (from ***Persistent inflammatory reaction)

Clinical features:
1. Synovitis
- with swelling + pain

  1. Ruptured extensor tendon at wrist joint
    - Mallet finger / Drop finger (DIP drop / flexed)
    - Boutonniere deformity (PIP flexed, DIP hyperextended)
    - Swan neck deformity (DIP flexed, PIP hyperextended)
  2. **Flexor tenosynovitis
    - Transverse carpal ligament (Flexor retinaculum) + Flexor tendon sheath —> more resistant to distension than Extensor retinaculum
    —> **
    Carpal tunnel syndrome + Digital tenosynovitis
    —> Treatment: Radical synovectomy
  3. Extra-articular manifestations:
    - Vasculitis
    - Pericarditis
    - Pulmonary nodules
    - Episcleritis
    - SC nodules (most common, 25% of patients with RA)
19
Q

Pattern of joint involvement in RA

A

Hand / Wrist
1. Proximal interphalangeal joint (PIP) (Thumb無呢個joint)
2. Metacarpophalangeal joint (MCP)
3. Carpometacarpal joint (CMC)

***NO Distal interphalangeal joint (DIP)!!!

Large joint:
1. Knee
2. Ankle
3. Elbow
4. Shoulder

Spine:
1. Cervical spine

20
Q

Criteria of diagnosing RA

A

O/T: use ***1987 ARA —> Good screening tool before referral to Rheumatologist

  • Cell-mediated
  • > = 4 of 7 + must > 6 weeks:
    1. **Morning stiffness >=1 hour
    2. **
    Arthritis of >=3 joint areas
    3. Arthritis of hand joints
    4. **Symmetric arthritis
    5. **
    Rheumatoid nodules
    6. ***Serum rheumatoid factor (IgM)
    7. Radiographical changes
21
Q

Radiological changes of RA

A

Start with Wrist —> Fingers

  1. Soft tissue swelling
    - joint space widened
  2. Periarticular osteopenia
  3. Peripheral cartilage + Bone erosion
  4. Joint space narrowing
    - Subchondral bone + Surface cartilage erosion
  5. Joint subluxation + Deformity
22
Q
  1. Gout
A
  • Chronic heterogenous disorder of Urate metabolism
    —> Deposition of ***Monosodium urate crystals in the joints + soft tissues
    —> Inflammation + Degenerative changes

Types:
1. Primary gout (90%)
- inborn error of metabolism

  1. Secondary gout (10%)
    - i.e. renal failure

Only 5% hyperuricemia patients will develop gout

Clinical features:
- ***Men
- >40yo
- Progressive if untreated:
1. Asymptomatic hyperuricemia
2. Acute gouty attack
3. Intercritical gout
4. Chronic tophaceous gout (Chalky gouty tophi)

Hallmarks of Gout:
1. Elevation of serum uric acid (usually)
2. Recurrent attacks (Flares) of acute inflammatory arthritis with monosodium uric crystals demonstrated in synovial fluid
3. Bone + Joint **destruction (some)
4. Aggregates of uric acid crystals (Tophi) in / around **
joints, soft tissues
5. Tophi in ***bone —> Erosion (some)
6. Kidney disease + Stones

Investigations:
1. X-ray
- ***Tophi replacing joint

  1. Aspiration of synovial fluid
    - **inflammatory cells
    - **
    monosodium urate crystal
23
Q

Common sites of acute flares

A
  1. ***1st MTP joint (most common)
  2. Olecranon bursa, Elbow, Wrist, Fingers
  3. Knee, Ankle, Subtalar, Midfoot
24
Q
  1. Psoriatic arthritis
A
  • Systemic condition
  • May be associated with Psoriasis: dry, red, scaly skin patches
  • 5-20% develop associated arthritis —> Inflamed synovium
  • Usually affect ***hands but also affect spine, feet, jaw

Epidemiology:
- M=F

Clinical features:
- Affect joints **asymmetrically (vs Symmetrical in RA)
- Red, dry, scaly skin lesion (vs Distinct nodules in RA)
- **
Pitting, ridging, crumbly appearance of nails
- ***Fingers first: Swelling in PIP + Deformities of DIP —> Larger joint (MCP) / Wrist / Over tendons (vs RA: affect wrist first)

Extra-articular features:
- Vasculitis / Raynaud’s phenomenon

25
Q

Investigations of Psoriatic arthritis

A
  1. Skin biopsy on skin lesions
  2. X-ray
    - ***Pencil in cup deformity at DIPJ
    - Swelling of non-bony structures
    - Joint space narrowing
    - Joint erosions
    - Spontaneous joint fusions
26
Q

Treatment of Inflammatory arthritis

A
  1. Systemic medications (by Rheumatologist)
  2. Local treatment
    - Splint / Physiotherapy
    - Steroid
    - **Synovectomy
    - **
    Surgical reconstruction (e.g. Tendon transfer for Mallet finger)
27
Q

Osteoarthritis

A

Degenerative joint disease:
- Loss of cushioning ***cartilage that covers bone surfaces at the joints

***Primary:
- Wear + Tear

***Secondary:
- Post-traumatic
- Post-inflammation (e.g. Post-RA, Post-Psoriatic arthritis)
- Post-infection

Clinical features:
1. Pain on loading, relieved by rest
3. **Stiffness, Swelling
4. **
Osteophytes —> Heberden’s nodes (DIP) + Bouchard’s nodes (PIP) —> may block movement / loss of ROM
5. **Deformity / Instability of joint
6. **
Diminished grip + pinch strength —> unable to perform ADL

Radiological changes:
1. Loss of joint space (vs Widening of joint space in RA initially)
2. Osteophyte
3. Subchondral sclerosis
4. Subchondral cysts

(From JC083:
- Commonest non-inflammatory arthritis
- Prevalence ↑ steeply with age (75% women >=65 yo)
- Primary vs Secondary OA

Sites:
- Weight bearing joints: Knee, Hips, Spine
- **CMC joint (wrist)
- **
DIP joint
- Trapeziometacarpal joints
—> >=3 joints involved —> ***Generalised OA

P/E:
- **Crepitus
- **
Minimal swelling

Imaging features:
- Loss of joint space (loss of cartilage)
- Osteophyte (marginal, abnormal bone proliferation)
- Subchondral cyst
- Subchondral sclerosis (sclerosed area: dead bone)
- **Preserved bone density (vs RA)
- **
Synovial hypertrophy
- Thickened capsule
- Joint deformity)

28
Q

Common sites of OA in hands

A
  1. ***CMC of thumb
  2. ***DIP
  3. PIP (less common)
  4. Radiocarpal joint of wrist

Other sites:
1. Hips
2. Knees
3. Lumbar spine
4. Cervical spine

29
Q

(From MSS03: Diagnosis of OA)

A

EULAR (European League Against Rheumatism)
3 signs
- Crepitus
- Restricted ROM
- Bony enlargement

3 symptoms
- Persistent pain
- Limited morning stiffness
- Reduced function

ACR (American College of Rheumatology)
- >50
- <30 mins morning stiffness
- Crepitus
- Bony tenderness
- No enlargement
- No palpable warmth

30
Q

Treatment of OA

A
  1. Conservative
    - Analgesic
    - Rest
    - Activity modification
    - Weight loss
    - Splint / Walking aids
    - Heat modalities?
  2. Steroid injection
    - esp. acute exacerbation
  3. Hyaluronic acid injection
    - no level 1 evidence
  4. Surgery
    - **Excisional arthroplasty (take away 2 joint surfaces, so do not rub against each other —> but less stable joint —> still diminished grip strength)
    - **
    Arthrodesis —> Joint fusion (Preferred choice in manual worker)
    - ***Joint replacement

(From MSS03:
1. Education and modify risk factors
- lifestyle modification (must walk more to strengthen cartilage, NOT advise to rest)
- ***weight loss
- walking aids
- understanding of disease

  1. Physical
    - ***muscle strengthening
    —> core muscles
    —> knee muscles
    - ROM exercise
    - muscle stretching
    - aerobic exercises
    - knee brace, shoe insoles
  2. Pharmacological
    - Acetaminophen
    - NSAID
    —> Non-selective
    —> COX-2 specific inhibitor
    - Topical agents
    - Others
    —> Narcotic analgesic
    —> Anticonvulsants (Neuralgia)
    —> Antidepressants
  3. Cartilage supplements
    - Glucosamine
    —> substrate for synthesis of proteoglycans
    - lack level I evidence
    - placebo effect
  4. Intra-articular injections
    - Hyaluronate
    —> Glycosaminoglycan
    —> Visco-supplementation
    ——> supplement viscosity of joint fluid —> lubrication and cushioning
    ——> pain relief (incomplete, not always, lasts 6-9 months)
  • Steroid (reserved for inflammatory causes)
    —> anti-inflammatory
    —> short term benefit
    —> no >4 times in single joint within 1 year
    —> side effects
  • Platelet-rich plasma (PRP)
    —> anti-inflammatory effect
    —> lack level I evidence
  • Stem cells
    —> lack level I evidence
  1. Surgical
    - Arthroscopy
    —> loose bodies, meniscal tear with locking symptoms in the knee
    —> arthroscopic lavage / debridement
    ——> washout debris, synovial fluid and remove damaged cartilage / bone
    ——> ineffective / surgical placebo
  • ***Realignment osteotomy
    —> redistribute stress to normal part of the joint
  • ***Joint replacement)
31
Q

SpC O/T OPD: Ganglion cyst in hand

A

Myxoid degeneration of scapholunate ligament —> gelatinous material accumulation —> push out from weak point in hand

Common locations:
- Dorsum of hand
- Volar aspect of hand
- A2 pulley
- Dorsum of feet